Feasibility of large language models for CEUS LI-RADS categorization of small liver nodules in patients at risk for hepatocellular carcinoma.

Background: Large language models (LLMs) offer opportunities to enhance radiological applications, but their performance in handling complex tasks remains insufficiently investigated.

Purpose: To evaluate the performance of LLMs integrated with Contrast-enhanced Ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) in diagnosing small (≤20mm) hepatocellular carcinoma (sHCC) in high-risk patients.

Materials And Methods: From November 2014 to December 2023, high-risk HCC patients with untreated small (≤20mm) focal liver lesions (sFLLs), were included in this retrospective study.

Multifunctional DNA-Metal Nanohybrids Derived From DNA-MgPPi Microhybrids by Rolling Circle Amplification.

Rolling circle amplification (RCA)-derived ultra-long DNA is highly attractive and versatile because of its diverse functionalities conferred by repeated DNA nanostructures. However, magnesium pyrophosphate (MgPPi) crystals, as byproducts of RCA, electrostatically interact with the DNA to form DNA microhybrids and hamper its broad bioapplications, as its large size is unfavorable for cellular uptake and decreases the density of functional DNA nanostructures. In this study, finely tuned synthesis strategies are developed to condense the microhybrids and replace non-functional MgPPi crystals with various functional metal nanostructures by reducing metal ions.

Amphibious Soft Robots Based on Programmable Actuators Fabricated by Brushing Chinese Ink on Paper.

Soft robots based on actuators that can work in both on-ground and on-water situations are environmentally adaptable and can accomplish tasks in complex environments. However, most current amphibious actuators need external stimuli to move on water and require complex preparation processes. Herein, amphibious Ink-paper/polyethylene programmable actuators and robots are proposed, which are fabricated by rapidly brushing Chinese ink on paper.

Confining Liquid Electrolytes in a Nitrogen-Rich Nanoporous Carbon Sponge for Superior Lithium-Ion Conduction.

Solid-state Li-ion batteries are recognized as highly promising energy storage devices due to their ability to overcome issues related to the inferior cycle life and potential risks of traditional liquid Li-ion batteries. However, developing solid-state electrolytes with fast Li-ion conductivity continues to be a major challenge. In this study, we present a family of quasi-solid-state electrolytes (QSSEs) synthesized by confining liquid electrolytes within a N-rich porous carbon sponge, exhibiting superior Li-ion conduction for solid-state battery applications.

Symmetry Engineering in a 2D Transition Metal Enables Reconfigurable P- and N-Type FETs.

Two-dimensional (2D) transition metals enable the elimination of metal-induced gap states and Fermi-level pinning in field-effect transistors (FETs), offering an advantage over conventional metal contacts. However, transition metal substrates typically exhibit nonoriented behaviors, leading to the inability to achieve monolingual responses with P- or N-type semiconductors. Here we devise symmetry engineering in an oxidized architectural MXene, termed OXene, which implements the exploiting and coupling of additional out-of-plane electron conduction and built-in polar structures.

Effect of Cytoskeletal Linker Protein GAS2L1 on Oligodendrocyte and Myelin Development.

Oligodendrocytes (OLs), the myelin-forming cells of the central nervous system (CNS), develop from OL precursor cells (OPCs) through a complex process involving significant morphological changes that are critically dependent on the dynamic interactions between cytoskeletal networks. Growth arrest-specific 2-like protein 1 (GAS2L1) is a cytoskeletal linker protein that mediates the cross-talk between actin filaments and microtubules. However, its role in OL and myelin development remains unknown.

Exploring symptom clusters and core symptoms during the vulnerable phase in patients with chronic heart failure: a network-based analysis.

Aims: To construct a symptom network of chronic heart failure patients in the vulnerable period and identify core symptoms and bridge symptoms between different symptom clusters.

Methods And Results: A convenience sampling method was used to select 402 patients with chronic heart failure within 3 months after discharge from the cardiology departments of two tertiary-level A hospitals in Zhenjiang City, and symptom-related entries of the Minnesota living with heart failure questionnaire (MLHFQ) were used to conduct the survey. Symptom networks were constructed using the R language.

[Correlation of Mutation with Clinical Features and Prognosis of Langerhans Cell Histiocytosis in Cildren].

Objective: To explore the gene mutations of Langerhans cell histiocytosis in children, and to analyze the correlation of mutation with clinical features and prognosis of LCH, so as to provide reference for clinical diagnosis and treatment.

Methods: Fluorescence PCR was used to detect gene mutations in paraffin-embedded tissue samples from 78 children with LCH, and the correlation of mutation with clinical characteristics and prognosis of LCH in children was analyzed.

Results: Among the 78 children, 41 cases (52.

[The Value of IgG Anti-A/Anti-B Antibody Titers after Absorption of IgG Anti-AB Antibodies in Predicting ABO Fetal Neonatal Hemolytic Disease].

Objective: To analyze the diagnostic value of IgG anti-A/anti-B antibody titer in the serum of type O pregnant women after absorption of IgG anti-AB antibody for ABO hemolytic disease of fetus and newborn (ABO-HDFN).

Methods: From February 2020 to September 2020, 235 samples of neonatal hemolytic disease whose mother's blood type O from Beijing Blood Center were selected. The titer of IgG anti-A/anti-B antibody in mother's serum before and after absorption of IgG anti -AB antibody was detected by microcolumn gel card, and the incidence of ABO-HDFN was statistically analyzed.

[Risk Factors of Primary Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Myeloid Malignancies].

Objective: To analyze the risk factors of primary poor graft function (PGF) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with myeloid malignancies and the impact of primary PGF on survival.

Methods: The clinical data of 146 patients with myeloid malignancies who underwent allo-HSCT in our hospital from January 2015 to December 2021 were retrospectively studied. Some relevant clinical parameters which may affect the development of primary PGF after allo-HSCT were selected for univariate and multivariate analysis, as well as performed survival analysis.

[The Preservation of HBV, HCV, HIV Viral Nucleic Acids in Plasma by Dry Spot Method and the Duration of Preservation].

Objective: To establish a method for preserving viral nucleic acids in plasma using a blood collection card based on the dry spot method, to predict the duration of nucleic acid preservation by establishing the Arrhenius equation, and to demonstrate the feasibility of this preservation method for the re-testing of nucleic acids in blood samples retained by blood banks.

Methods: Plasma samples positive for HBV, HCV, and HIV nucleic acids were prepared into preservation cards in the form of dry plasma spots for storage. The prepared preservation cards were placed under accelerated storage conditions at 37, 45, 50, and 55 ℃.

The intrinsic functional connectivity of psychopathy and its relation to self-control.

Previous research has found functional connectivity in various networks to be altered in psychopathy and has theorised a link between these networks and the self-control-related deficits observed in psychopathy. However, this theory has yet to be tested adequately and empirically. The present study investigated the association between psychopathy, self-control, and intrinsic functional connectivity in 179 healthy adults from the MPI Leipzig Mind Brain Body dataset.

Extended Reality Technology for Alleviating Adult Dental Anxiety: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Objectives: To assess the effectiveness of extended reality (XR) technology in reducing dental anxiety in adults, through a systematic review and meta-analysis.

Methods: Comprehensive electronic and manual searches were conducted to identify randomized controlled trials published up to November 23, 2024, with no restrictions on publication year or language. Key outcomes included changes in anxiety and pain levels and cardiovascular indicators, such as blood pressure, heart rate, and oxygen saturation (SpO2).

Intense and vibrant color construction and functionalization for protein macromolecule/polyamide two-component fabric by sustainable microbial nano prodigiosins based on adjustable pigment allocation.

Silk/polyamide fabric inherits the advantages of natural and synthetic fibers, making them remarkable in textile and garment field. However, the use of synthetic chemicals for color construction and functionalization of silk/polyamide fabrics is problematic because of their non-renewable resources and harmful effects on the environment. Furthermore, achieving even color construction of silk and polyamide fibers in one bath is challenging due to their significant differences in chemical structure and surface properties.

SIGIRR plays a dual role in zebrafish infected with Edwardsiella piscicida: Boosting digestive system wellness and mitigating inflammation.

Single immunoglobulin interleukin-1 receptor-associated protein (SIGIRR) negatively regulates the inflammatory response induced by bacterial infection by inhibiting the excessive synthesis of inflammatory mediators and overactivation. This inhibitory mechanism reduces the fish's susceptibility to pathogens and enhances survival rates. Zebrafish lacking the SIGIRR gene were generated using CRISPR/Cas9 gene knockout technology.

Response surface methodology and Box-Behnken design optimization of Sulfaquinoxaline removal efficiency and degradation mechanisms by Bacillus sp. strain DLY-11.

Antibiotic pollution, particularly the persistence of Sulfaquinoxaline (SQ) residues in livestock and poultry farming environments, has emerged as a pressing environmental concern. Despite this, there remains a limited understanding of the optimized conditions and mechanisms for the efficient degradation of SQ by microorganisms. To address this knowledge gap, we isolated Bacillus sp.

Targeted LNPs deliver IL-15 superagonists mRNA for precision cancer therapy.

Interleukin-15 (IL-15) emerges as a promising immunotherapeutic candidate, but the therapeutic utility remains concern due to the unexpected systematic stress. Here, we propose that the mRNA lipid nanoparticle (mRNA-LNP) system can balance the issue through targeted delivery to increase IL-15 concentration in the tumor area and reduce leakage into the circulation. In the established Structure-driven TARgeting (STAR) platform, the LNP and LNP can effectively and selectively deliver optimized IL-15 superagonists mRNAs to local and lungs, respectively, in relevant tumor models.

A spatially resolved multi-omic single-cell atlas of soybean development.

Cis-regulatory elements (CREs) precisely control spatiotemporal gene expression in cells. Using a spatially resolved single-cell atlas of gene expression with chromatin accessibility across ten soybean tissues, we identified 103 distinct cell types and 303,199 accessible chromatin regions (ACRs). Nearly 40% of the ACRs showed cell-type-specific patterns and were enriched for transcription factor (TF) motifs defining diverse cell identities.

A novel therapeutic strategy for leukopenia: Miltefosine activates the Ras/MEK/ERK pathway to promote neutrophil differentiation.

Leukopenia, marked by diminished white blood cell (WBC) counts, presents significant challenges in the management of hematological malignancies and immunocompromised patients. This study evaluated the therapeutic potential of miltefosine (MFS), a phospholipid analogue, for treating leukopenia. In vitro studies using HL60 and NB4 cells revealed that MFS effectively promoted neutrophil differentiation and function, evidenced by the upregulation of surface markers CD11b, CD11c, CD14, and CD15, as well as enhanced bactericidal activity assessed through the NBT reduction assay.

Aptamer-based DNAzyme walker electrochemical biosensing strategy for Acinetobacter baumannii detection.

In this study, an innovative electrochemical biosensor was developed for the rapid, specific, and sensitive detection of Acinetobacter baumannii without the need for sample pretreatment. The biosensor utilized an aptamer as a specific capture probe for A. baumannii and employed a self-powered DNAzyme walker cleavage cycle reaction to achieve signal amplification.

A π-hole bond functionalized magnetic nanosorbent for the solid phase extraction of 15 polycyclic aromatic hydrocarbons from environmental water samples.

A new type of sorbent functionalized with π-hole bond, perfluoronaphthyl bonded magnetic nanosorbent (FeO@SiO-CF), was designed and synthesized. The morphology, structure and magnetic properties of the sorbent were characterized. The results of a comparative experiment with naphthyl bonded magnetic nanosorbent (FeO@SiO-CH) revealed that the π-hole bonds between perfluoronaphthyl and PAHs improved adsorbilities for PAHs in water compared to the traditional π-π interactions between naphthyl and PAHs.

Mpox Recrudescence after SARS-CoV-2 Coinfection in a Patient with AIDS.

People living with HIV (PLWH) are known to exhibit more severe or prolonged symptoms of mpox (formerly monkeypox). However, the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on PLWH with mpox has not been adequately described. We report a case of mpox in an AIDS patient who had recurrent symptoms due to SARS-CoV-2 infection.

Upregulated SAE1 Drives Tumorigenesis and Is Associated with Poor Clinical Outcomes in Breast Cancer.

Background: The purpose of this study was to analyze SUMO activating enzyme subunit 1 (SAE1) expression in breast cancer (BC). Through bioinformatics analysis and in vitro experiments, the biological function and possibly associated signal pathways of SAE1 in BC were further analyzed.

Methods: Bioinformatics analysis was applied to analyze SAE1 expression in BC and normal breast tissues, its relationship with clinicopathologic characteristics and prognosis in BC patients, and data from the Cancer Genome Atlas database and Gene Expression Omnibus dataset.