Publications by authors named "Changxi Liao"
The Association between Gut Microbiota and Its Metabolites in Gestational Diabetes Mellitus.
J Microbiol Biotechnol
October 2024
Article Synopsis
- - The study investigates the relationship between gut microbiome and metabolites in pregnant women with gestational diabetes mellitus (GDM) compared to those without, highlighting the role of gut microbial metabolites in diabetes.
- - Key findings show that phenylalanine and nucleotide metabolism pathways are notably different between the two groups, with specific metabolites like Phenylalanylglycine and uracil being significantly altered in GDM patients.
- - An increase in the gut symbiont Clostridium, part of the Firmicutes class, was linked to disruptions in phenylalanine metabolism in GDM, suggesting a potential therapeutic target for managing the condition.
High-risk Human Papillomavirus Infection in Putian, China: A Cross-sectional Analysis of 98085 Women.
J Coll Physicians Surg Pak
June 2023
Objective: To assess high-risk human papillomavirus (hrHPV) infection among women undergoing cervical cancer screening in Putian for establishing an optimal cervical cancer screening mode and preventive vaccination strategy for HPV.
Study Design: Cross-sectional study. Place and Duration of the Study: The Affiliated Hospital of Putian University for cervical cancer screening period, from August 2020 to December 2022.
For analyzing the distribution characteristics of MTHFR C677T polymorphism in Chinese females in order to provide information for reducing birth defects and formulating public health policies to prevent congenital malformations. Literature search in the last 6 years on "MTHFR C677T," "polymorphism" and "methylene tetrahydrofolate reductase." The included literature provides the MTHFR C677T frequency in healthy females in the corresponding regions.
View Article and Find Full Text PDFTo investigate the effect of optimized GPC3-specific chimeric antigen receptor (GPC3-CAR) structure on killing hepatocellular carcinoma (HCC) cells. We constructed three lentiviral expression vectors with different CAR structures by genetic engineering and molecular cloning techniques. These three CAR structures shared the same intracellular signaling region consisting of 4-1BB and CD3ζ, but had different hinge and transmembrane regions.
View Article and Find Full Text PDFAims: To investigate the role of cIAP2 in the malignant biological behaviours of hepatocellular carcinoma (HCC) cells and determine its mechanism of action.
Main Methods: cIAP2 protein expression was detected via immunohistochemistry (IHC) in 102 HCC specimens and 43 paracancerous liver tissues, and its relationship with clinicopathological features and patient prognosis was analysed. Then, short interfering RNA (siRNA) technology was used to knock down cIAP2 expression in BEL7402 and HepG2 cells.