Publications by authors named "Changwang Wang"
Previous studies have reported on the association between the polymorphism in the () gene and opioid use disorder (OUD) with inconsistent outcomes. The goal of this study was to examine the correlation of the polymorphism and OUD using a meta-analysis approach. Six electronic databases, including PubMed, Web of Science, Cochrane Library, EMBASE, Wanfang and CNKI, were searched thoroughly for relevant studies on the association of the polymorphism and OUD up to September, 2021.
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- The study examined the relationship between cognitive functions and the risk of developing psychosis in Chinese college students identified as clinically high risk (CHR), involving 115 CHR students and 99 healthy controls from Wuhan.
- Participants were monitored for two years, with 29 out of 107 CHR individuals developing a psychotic disorder by the end of the study, showing that cognitive impairments were prevalent among CHR individuals compared to healthy controls.
- Significant cognitive deficits were found in visual learning, working memory, and problem-solving abilities among those who converted to psychosis (CHR-C) compared to those who did not (CHR-NC), suggesting that these cognitive areas may serve as predictors for psychosis.
Background: Prodynorphin (PDYN) gene polymorphisms have been linked with opioid dependence (OD) with conflicting outcomes, the aim of this study is to synthesize the existing evidence of the association between PDYN polymorphisms and OD susceptibility.
Methods: Four databases including PubMed, EMBASE, Web of Science, and Wanfang were retrieved for relevant studies before August, 2018. All identified studies were evaluated using predetermined inclusion and exclusion criteria.