Increased Expression of PCNA-AS1 in Colorectal Cancer and its Clinical Association.

Background: The aim is to study the expression of PCNA-AS1 in colorectal cancer (CRC) tissue and paired-adjacent normal tissue and the relationship between its expression level and clinical pathological features.

Methods: Using real-time qPCR, PCNA-AS1 expression levels were detected in 114 cases to establish the relationship between its expression and clinicopathologic features. Moreover, the expressions of PCNA-AS1 were investigated in CRC and normal colonic epithelial cell lines.

Novel approach to hydroxy-group-containing porous organic polymers from bisphenol A.

We successfully employed bisphenol A and several different formyl-containing monomers as useful building blocks to construct a series of hydroxy-group-containing porous organic polymers in a sealed tube at high temperature. Fourier transform infrared and solid-state C CP/MAS NMR spectroscopy are utilized to characterize the possible structure of the obtained polymers. The highest Brunauer-Emmet-Teller specific surface area of the phenolic-resin porous organic polymers (PPOPs) is estimated to be 920 m g.

A prospective comparison of short term results and functional recovery after laparoscopic subtotal colectomy and antiperistaltic cecorectal anastomosis with short colonic reservoir vs. long colonic reservoir.

Background: To observe and compare the short term results and functional recovery of laparoscopic subtotal colectomy with antiperistaltic cecorectal anastomosis (LSCACRA) in the treatment of Adult slow transit constipation (STC) with two different reservoir length: short colonic reservoir and long colonic reservoir.

Methods: All STC patients treated with LSCACRA between April 2007 and December 2011 at our institution were followed up. Patients with 2 cm to 3 cm ascending colon preserved above the ileocecal junction were designated as observation group, whereas those preserved by 10 cm to 15 cm were classified as control group.

Open versus laparoscopy-assisted D2 radical gastrectomy in advanced upper gastric cancer: a retrospective cohort study.

Background/aims: We conducted this study to compare open versus laparoscopy-assisted D2 radical gastrectomy in advanced upper gastric cancer.

Methodology: We reviewed 84 advanced gastric cancer patients who had pancreas-and-spleen preserving D2 lymph node dissection between March 2008 and March 2012. A comparative study was made about the short-term and long-term effect between laparoscopy-assisted D2 radical gastrectomy (LAG) on 41 patients and open D2 radical gastrectomy (OG) on 43 patients.

Total Syntheses of (-)-Mesembrane and (-)-Mesembrine via Palladium-Catalyzed Enantioselective Allylic Substitution and Zirconium-Promoted Cyclization.

4-Arylhexahydroindole derivatives 5 were synthesized from 2-arylcyclohexenyl allylamine derivatives 4, which have a large protecting group on nitrogen, using zirconium-promoted cyclization. Reaction of 4e with Cp(2)ZrBu(2), followed by treatment with MeMgBr and then O(2), gave 2a in 63% yield by a one-pot reaction, since the approach of O(2) to zirconium was prevented by the aryl group. The total syntheses of (+/-)-mesembrane and (+/-)-mesembrine were achieved starting from 2a.