Activation of osteoblast ferroptosis by risperidone accelerates bone loss in mice models of schizophrenia.

Background: Ferroptosis is an iron-dependent regulatory cell death, which plays an essential role in bone loss. This study investigated whether the mechanism of risperidone (RIS)-induced bone loss is related to ferroptosis.

Methods: The schizophrenia mice were induced by administering MK-801.

Risperidone accelerates bone loss in mice models of schizophrenia by inhibiting osteoblast autophagy.

Background: Risperidone (RIS) is the first-line drug in the clinical treatment of schizophrenia, and long-term use may lead to bone loss and even osteoporosis. This study investigated whether the mechanism of RIS-induced bone loss is related to autophagy.

Methods: The schizophrenia mice were established with the administration of MK-801.