Corrigendum: Global Lysine Crotonylation Alterations of Host Cell Proteins Caused by Effector BspF.

[This corrects the article DOI: 10.3389/fcimb.2020.

Global Lysine Crotonylation Alterations of Host Cell Proteins Caused by Effector BspF.

In spp., the type IV secretion system (T4SS) is essential for bacterial intracellular survival and inhibition of the host innate immune response. The T4SS secretes 15 different effectors to escape host immunity and promote intracellular replication.

A Type I-F Anti-CRISPR Protein Inhibits the CRISPR-Cas Surveillance Complex by ADP-Ribosylation.

CRISPR-Cas systems are bacterial anti-viral systems, and phages use anti-CRISPR proteins (Acrs) to inactivate these systems. Here, we report a novel mechanism by which AcrIF11 inhibits the type I-F CRISPR system. Our structural and biochemical studies demonstrate that AcrIF11 functions as a novel mono-ADP-ribosyltransferase (mART) to modify N250 of the Cas8f subunit, a residue required for recognition of the protospacer-adjacent motif, within the crRNA-guided surveillance (Csy) complex from Pseudomonas aeruginosa.