Functionalized Electrospun Double-Layer Nanofibrous Scaffold for Wound Healing and Scar Inhibition.

Considerable advances have been made in developing materials that promote wound healing and inhibit scar formation in clinical settings. However, some challenges, such as cumbersome treatment processes and determination of optimal treatment time, remain unresolved. Thus, developing a multifunctional wound dressing with both wound healing and scar inhibition properties is crucial.

Potential multifunctional agents with anti-hepatoma and anti-inflammation properties by inhibiting NF-кB activation.

Inhibition of NF-κB signalling has been demonstrated as a therapeutic option in treating inflammatory diseases and cancers. Herein, we synthesized novel dissymmetric 3,5-bis(arylidene)-4-piperidones (BAPs, ) and characterized fully. MTT and ELISA assay were performed to screen the anti-hepatoma and anti-inflammation properties.

Functionalized Biomimetic Composite Nanfibrous Scaffolds with Antibacterial and Hemostatic Efficacy for Facilitating Wound Healing.

An ideal wound dressing should not only promote rapid hemostasis and wound healing but also have good biocompatibility, antimicrobial activities, and should mimic the skin's physiological function. In the present study, five O-quaternized chitosan (QAS-CS) materials with satisfactory antibacterial activity and no cytotoxicity were successfully synthesized. Furthermore, we reported the synthesis and characterization of the two novel composite nanofibrous scaffolds consisting of selfdeveloped collagen (COL), quaternary ammonium salt (QAS) or QAS-CS and polycaprolactone (PCL) or polyvinyl alcohol (PVA) with an electrospinning approach.