Publications by authors named "Changmei Hu"
The abnormal expression of PHAX was observed in esophageal cancer, however, its specific function and mechanism remain to be further elucidated. We demonstrated that PHAX, LIN28B, and PBX3 were upregulated in esophageal cancer, while TET2 was downregulated. Elevated PHAX correlated with adverse outcomes among esophageal cancer patients.
View Article and Find Full Text PDFBackground: Acute myeloid leukemia (AML) is a hematopoietic malignancy. Chidamide has shown anti-cancer effect in different malignancies. The function of Chidamide in glycolysis in AML cells remains unclear.
View Article and Find Full Text PDFBackground: The long noncoding RNAs' (lncRNAs) effect on cancer therapy resistance by targeting microRNA (miRNA) in the regulation of drug resistance genes has attracted more and more attention. This study attempted to explore the mechanism of "lncRNA NR2F1-AS1/miR-483-3p/IGF1″ axis in azacitidine resistance of THP-1 cells.
Methods: THP-1 cells were treated with azacitidine to construct THP1-Aza cells.
The aim of this study was to investigate the functions and molecular mechanism of miR-196a in esophageal cancer (EC). miR-196a as well as UHRF2 and TET2 mRNA and protein levels in EC tissues and cells were detected using quantitative real-time PCR or western blot, respectively. Cell proliferation was evaluated via MTT assay.
View Article and Find Full Text PDFMicroRNA (miR)-196a is upregulated in various types of malignancy, including esophageal squamous cell carcinoma (ESCC); however, its role in ESCC is currently unclear. The present study aimed to investigate the biological role and molecular mechanism of miR-196a in ESCC. The expression levels of miR-196a in 25 tumor tissues and adjacent non-tumor tissues from patients with ESCC were measured by reverse transcription-quantitative polymerase chain reaction.
View Article and Find Full Text PDFArticle Synopsis
- Accumulating evidence suggests that microRNAs play a significant role in cancer development and treatment response, with microRNA-375 (miR-375) notably downregulated in various cancers.
- This study focused on the effects of miR-375 in esophageal cancer, revealing its reduced levels in tumor tissues and cancer cell lines linked to inhibited cell growth and invasion.
- Findings indicate that miR-375 directly targets metadherin (MTDH), affecting other cancer-related proteins, suggesting its potential as a therapeutic target for esophageal squamous cell carcinoma (ESCC).
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract arising in individuals with genetic predisposing factors and abnormalities of the immune system. Myelodysplastic syndrome (MDS), an acquired clonal hematologic disorder, is characterized by peripheral blood cytopenia, dysplastic changes in several types of hematopoietic cells of the bone marrow and peripheral blood, and a high risk of transformation to acute leukemia. CD rarely occurs in combination with MDS, and MDS treatment with hematopoietic stem cell transplantation (HSCT) has not been frequently reported.
View Article and Find Full Text PDFObjective: To survey the current availability of expertise in diagnosis and treatment of neurological diseases in grade II hospitals (primary hospitals) in Beijing.
Methods: Observation, personal in-depth interview and structured questionnaire methods were conducted to survey the status of neurology health care system.
Results: From June to August 2005, 66 grade II suburban and urban hospitals in Beijing of China were investigated.