Publications by authors named "Changlu Zhang"

Hazard perception refers to a driver's ability to identify potential hazards on the road. Although studies have shown that overconfidence affects drivers' ability to perceive hazards, the neural processing of hazard perception in overconfident drivers under different hazard types has rarely been investigated. A mixed experimental design of 2 (hazard type: hazards, no hazards) × 2 (driver group: overconfident driver, control group) was used.

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Objective: Evaluation of tumor microvascular morphology is of great significance in tumor diagnosis, therapeutic effect prediction, and surgical planning. Recently, two-dimensional ultrasound localization microscopy (2DULM) has demonstrated its superiority in the field of microvascular imaging. However, it suffers from planar dependence and is unintuitive.

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The present study attempted to explore the effects of sleep deprivation on the visual search patterns and hazard response times of taxi drivers when they encountered different types of hazards. A two (driver groups: sleep deprivation or control) × two (hazard types: covert hazard or overt hazard) mixed experimental design was employed. A total of 60 drivers were recruited, half of whom were in the sleep-deprived group and half of whom were in the control group.

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Currently, sentiment analysis is a research hotspot in many fields such as computer science and statistical science. Topic discovery of the literature in the field of text sentiment analysis aims to provide scholars with a quick and effective understanding of its research trends. In this paper, we propose a new model for the topic discovery analysis of literature.

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Morphological and hemodynamic changes in the ocular vasculature are important signs of various ocular diseases. The evaluation of the ocular microvasculature with high resolution is valuable in comprehensive diagnoses. However, it is difficult for current optical imaging techniques to visualize the posterior segment and retrobulbar microvasculature due to the limited penetration depth of light, particularly when the refractive medium is opaque.

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Background: Portal vein tumour thrombus (PVTT) is the main pathway of HCC intrahepatic metastasis and is responsible for the poor prognosis of patients with HCC. However, the molecular mechanisms underlying PVTT vascular metastases have not been fully elucidated.

Methods: NDRG1 expression was assessed by immunohistochemistry and immunoblotting in clinical specimens obtained from curative surgery.

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Purpose: The present study aimed to adapt the Attitudes and Beliefs about Sleepy Driving Scale (ABSDS) to a sample of Chinese drivers and to examine its reliability and validity.

Methods: Five hundred and twenty drivers aged 18 to 56 years old were asked to complete the ABSDS and a validated Chinese version of the Prosocial and Aggressive Driving Inventory.

Results: The results showed that the final Chinese version of the ABSDS contained 7 items with satisfactory reliability.

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Purpose: Poor sleep quality is closed related with driving accidents. However, due to the lack of a valid instrument for assessing drivers' sleep quality, few studies have examined drivers' sleep quality and its associations with driving behaviours and traffic accidents in China. The aim of this paper is to revise the Sleep Quality Scale (SQS) and assess its reliability and validity in Chinese drivers.

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Hepatitis B-associated hepatocellular carcinoma (HCC) is often accompanied by severe vascular invasion and portal vein tumor thrombus, leading to a poor prognosis. However, the underlying mechanism of this disease remains obscure. In this study, we demonstrate that the hepatitis B virus (HBV)-encoded gene HBx induces high IL8 production through MEK-ERK signal activation, leading to enhanced endothelial permeability to facilitate tumor vascular invasion.

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Phosphoprotein enriched in astrocytes 15 (PEA‑15) plays an important role in controlling biological behaviors of cancer cells. In the present study, we demonstrated that PEA‑15 was overexpressed in gastric cancer tissues and associated with tumor staging, differentiation, pathological types and the prognosis of patients. Gastric cancer cells expressed variable levels of PEA‑15 and its bi‑phosphorylation forms, p‑PEA‑15 (Ser104) and p‑PEA‑15 (Ser116).

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