DNASimCLR: a contrastive learning-based deep learning approach for gene sequence data classification.

Background: The rapid advancements in deep neural network models have significantly enhanced the ability to extract features from microbial sequence data, which is critical for addressing biological challenges. However, the scarcity and complexity of labeled microbial data pose substantial difficulties for supervised learning approaches. To address these issues, we propose DNASimCLR, an unsupervised framework designed for efficient gene sequence data feature extraction.

ML1206 Strain Enhances Stress Resistance and Extends the Lifespan in via FOXO/DAF-16.

The antioxidant effect of probiotics has been widely recognized across the world, which is of great significance in food, medicine, and aquaculture. There are abundant marine microbial resources in the ocean, which provide a new space for humans to explore new probiotics. Previously, we reported on the anti-infective effects of ML1206, a potential marine probiotic.

Forskolin enhanced the osteogenic differentiation of human dental pulp stem cells in vitro and in vivo.

Background/purpose: Human dental pulp stem cells (hDPSCs) are multipotent adult stem cells that can differentiate into various lineages such as odontoblasts, osteoblasts, and chondrocytes. Regulation of hDPSCs differentiation with small-molecule compounds can be a useful tool for tissue engineering and regenerative therapy. Forskolin is an agonist of adenylate cyclase that promotes cyclic adenosine monophosphate production.

Effects of sodium hypochlorite and ethylenediaminetetraacetic acid on proliferation, osteogenic/odontogenic differentiation, and mechanosensitive gene expression of human dental pulp stem cells.

Sodium Hypochlorite (NaOCl) and Ethylene Diamine Tetraacetic Acid (EDTA) can change the biochemical and biophysical properties of dentin. However, the response of human dental pulp stem cells (hDPSCs) to NaOCl and EDTA-treated dentin remains unknown. This study was conducted to investigate the effect of NaOCl and EDTA on cell proliferation, osteogenic/odontogenic differentiation, and the response to mechanosensitive gene expression in hDPSCs.

NBCe1 Regulates Odontogenic Differentiation of Human Dental Pulp Stem Cells via NF-B.

Background And Objectives: Dental pulp stem cells (DPSCs) play an important role in the repair of tooth injuries. Electrogenic sodium bicarbonate cotransporter 1 (NBCe1) is a Na-coupled HCO transporter encoded by the solute carrier 4A4 () gene and plays a crucial role in maintaining the pH of DPSCs. Our previous research confirmed that NBCe1 is highly expressed in odontoblasts during the development of the tooth germ.

Missing Value Estimation Methods Research for Arrhythmia Classification Using the Modified Kernel Difference-Weighted KNN Algorithms.

Electrocardiogram (ECG) signal is critical to the classification of cardiac arrhythmia using some machine learning methods. In practice, the ECG datasets are usually with multiple missing values due to faults or distortion. Unfortunately, many established algorithms for classification require a fully complete matrix as input.

Can hemozoin alone cause host anaemia?

Both schistosomes and malaria parasites produce hemozoin and cause host anaemia. However, the relationship between anaemia and hemozoin is unclear. Although some studies have proposed that hemozoin is related to anaemia in malaria patients, whether hemozoin alone can cause anaemia in patients infected by malaria parasites or schistosomes is uncertain.