Xihuang pills targeting the Warburg effect through inhibition of the Wnt/β-catenin pathway in prostate cancer.

Objective: Prostate cancer, marked by a high incidence and mortality rate, presents a significant challenge, especially in the context of castration-resistant prostate cancer (CRPC) with limited treatment options due to drug resistance. This study aims to explore the anti-tumor effects of Xihuang Pills (XHP) on CRPC, focusing on metabolic reprogramming and the Wnt/β-catenin pathway.

Methods: In vitro and in vivo biofunctional assays were employed to assess the efficacy and mechanisms of XHP.

Sub-micron pixel polarization-sensitive photodetector based on silicon nanowire.

Silicon nanowire is a potential candidate to be used as polarization-sensitive material, but the relative mechanism of polarization response must be carried out. Herein, a sub-micron metal-single silicon nanowire-metal photodetector exhibits polarization-sensitive characteristics with an anisotropic photocurrent ratio of 1.59 at 780 nm, an excellent responsivity of 24.

Efficient uranium sequestration ability and mechanism of live and inactivated strain of Streptomyces sp. HX-1 isolated from uranium wastewater.

Prokaryotes are effective biosorbents for the recovery of uranium and other heavy metals. However, the potential mechanism of uranium bioaccumulation by filamentous strain (actinobacteria) remains unclear. This study demonstrates the potential for and mechanism of uranium bioaccumulation by living (L-SS) and inactivated (I-SS) Streptomyces sp.

Development of alternative herbals remedy for gastric cancer based on transcriptomic analysis of immune infiltration and ferroptosis.

Screening out potential herbal medicines and herbal ingredients for the treatment of gastric cancer based on transcriptomic analysis of immune infiltration and ferroptosis. Gene expression profiles of gastric tumour tissues and normal tissue samples were obtained from the GEO database and the samples were analysed for immune cell infiltration condition and differential expressed genes of ferroptosis. Key genes were screened by protein-protein interaction (PPI) and enrichment analysis, and molecular docking was used to predict and preliminary validate potential herbal and traditional Chinese medicine components for gastric cancer based on the key genes.

A Design Method of Two-Dimensional Subwavelength Grating Filter Based on Deep Learning Series Feedback Neural Network.

Subwavelength grating structure has excellent filtering characteristics, and its traditional design method needs a lot of computational costs. This work proposed a design method of two-dimensional subwavelength grating filter based on a series feedback neural network, which can realize forward simulation and backward design. It was programed in Python to study the filtering characteristics of two-dimensional subwavelength grating in the range of 0.

Preparation of Fe Doped High-Ordered TiO Nanotubes Arrays with Visible Photocatalytic Activities.

In this paper, the Fe doped rutile phase TiO nanotubes arrays (NTAs) were prepared in a low temperature water-assistant crystallization method. It is noteworthy that the Fe doping hardly hinders either the crystallization of rutile TiO NTAs or the highly-ordered nanotubular morphologies. Moreover, Fe did not form other compound impurities, which indicated that Fe substitute Ti into the lattice of TiO.

Tunable Optical Properties of Amorphous-Like GaO Thin Films Deposited by Electron-Beam Evaporation with Varying Oxygen Partial Pressures.

GaO thin films were fabricated by the electron-beam evaporation technique at a varying oxygen partial pressure from 0 to 2.0 × 10 Pa. The effect of oxygen partial pressure on the crystalline structure and optical properties of the GaO films was analyzed using sophisticated techniques including X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), Raman spectroscopy, spectroscopic ellipsometry, ultraviolet-visible spectroscopy and a laser-induced damage test system.

Assessment of natural radioactivity and consequent radiological hazard in different brands of commercialized bottled mineral water produced in China.

As one of the drinking water quality parameters, natural radioactivity parameters are recommended to prevent a potential health threat to the public. In this study, the gross-α and gross-β activity concentrations in 15 different brands of commercial bottled mineral water consumed in China were analyzed to evaluate the quality and corresponding health impact on the population. The activity concentrations of gross-α and gross-β in different samples varied from 4.

Stereoselective Pharmacokinetics and Chiral Inversions of Some Chiral Hydroxy Group Drugs.

Background: Chiral safety, especially chiral drug inversion in vivo, is the top priority of current scientific research. Medicine researchers and pharmacists often ignore that one enantiomer will be converted or partially converted to another enantiomer when it is ingested in vivo. So that, in the context that more than 50% of the listed drugs are chiral drugs, it is necessary and important to pay attention to the inversion of chiral drugs.

Antibacterial Mechanism of Vanillic Acid on Physiological, Morphological, and Biofilm Properties of Carbapenem-Resistant Enterobacter hormaechei.

Abstract: Many studies have evaluated the antimicrobial activity of natural products against various microorganisms, but to our knowledge there have been no studies of the possible use of natural products for their antimicrobial activity against Enterobacter hormaechei. In this study, we investigated vanillic acid (VA) for its antimicrobial activities and its modes of action against carbapenem-resistant E. hormaechei (CREH).

RETRACTED: Antibacterial and antibiofilm activity of ursolic acid against carbapenem-resistant Enterobacter cloacae.

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).

Synthesis, Giant Dielectric, and Pyroelectric Response of [001]-Oriented Pr Doped Pb(MgNb)O₃-PbTiO₃ Ferroelectric Nano-Films Grown on Si Substrates.

The [001]-oriented Pr doped Pb(MgNb)O₃-0.30PbTiO₃ (Pr-PMN-PT) thin films with a composition near the morphotropic phase boundary (MPB) were synthesized by a sol⁻gel method. The crystal structure was characterized using X-ray diffraction.

Engineering a high-yield glutathione strain of Hansenula polymorpha using ion beam implantation.

To generate an industrial strain of Hansenula polymorpha capable of yielding greater levels of glutathione (GSH), wild strain H. polymorpha DL-1 cells were mutated using a nitrogen ion beam, a novel mutagen. At an energy level of 20 keV and dose of 2.