Endosomal catabolism of phosphatidylinositol 4,5-bisphosphate is fundamental in building resilience against pathogens.

Endosomes are characterized by the presence of various phosphoinositides that are essential for defining the membrane properties. However, the interplay between endosomal phosphoinositides metabolism and innate immunity is yet to be fully understood. Here, our findings highlight the evolutionary continuity of RAB-10/Rab10's involvement in regulating innate immunity.

Age-associated decline in RAB-10 efficacy impairs intestinal barrier integrity.

The age-related decline in the ability of the intestinal barrier to maintain selective permeability can lead to various physiological disturbances. Adherens junctions play a vital role in regulating intestinal permeability, and their proper assembly is contingent upon endocytic recycling. However, how aging affects the recycling efficiency and, consequently, the integrity of adherens junctions remains unclear.

Hospitalized eye injury in a large industrial city of South-Eastern Asia.

Background: Wearing appropriate eye-protection devices in workplace, sports and motorcycling have not been a routine in most of Asian countries. The purpose of this study is to assess the frequency, causes, mechanisms, functional outcomes and costs of hospitalized eye injuries in a large industrial city in South Eastern Asia.

Methods: A retrospective review of the hospital admission files of ocular trauma admitted to the Kaohsiung Medical University Hospital from January 2001 to December 2002.