Doxorubicin-induced cardiotoxicity (DIC) is one of the most severe side effects of doxorubicin, yet the underlying mechanisms remain incompletely understood. Our results showed that Neutrophil extracellular traps (NETs) accumulated in plasma and cardiac tissue after doxorubicin treatment. The inhibition of NETs formation by Pad4 gene ablation significantly attenuated doxorubicin-induced arrhythmia, prolonged survival time and reduced the levels of Troponin T (cTnT) and creatine kinase MB (CK-MB) in mice.
View Article and Find Full Text PDFBuilding heterojunctions is a promising strategy for the achievement of highly efficient photocatalysis. Herein, a novel SnInS@ZnO Z-scheme heterostructure with a tight contact interface was successfully constructed using a convenient two-step hydrothermal approach. The phase composition, morphology, specific surface area, as well as photophysical characteristics of SnInS@ZnO were investigated through a series of characterization methods, respectively.
View Article and Find Full Text PDFDeep-subwavelength features have a minimal impact on wave transport in all dielectric systems; thus the homogenization approach was commonly adopted. Recently, the breakdown of effective medium theory (EMT) for the incident wave near the total reflection (TR) angle was demonstrated in a deep-subwavelength dielectric multilayer. Additionally, anomalous transmission was reported at angles exceeding the TR angle when introducing disorder and was attributed to Anderson localization.
View Article and Find Full Text PDFFemtosecond laser filamentation is a unique nonlinear optical phenomenon when high-power ultrafast laser propagation in all transparent optical media. During filamentation in the atmosphere, the ultrastrong field of 10-10 W/cm with a large distance ranging from meter to kilometers can effectively ionize, break, and excite the molecules and fragments, resulting in characteristic fingerprint emissions, which provide a great opportunity for investigating strong-field molecules interaction in complicated environments, especially remote sensing. Additionally, the ultrastrong intensity inside the filament can damage almost all the detectors and ignite various intricate higher order nonlinear optical effects.
View Article and Find Full Text PDFActive control of terahertz waves is a critical application for terahertz devices. Silicon is widely used in large-scale integrated circuit and optoelectronic devices, and also shows great potential in the terahertz field. In this paper, a p-Si hybrid metasurface device is proposed and its terahertz characteristics under avalanche breakdown effect is investigated.
View Article and Find Full Text PDF