Publications by authors named "Changlin Ke"
Objective: To observe the effect of thymalfasin on myeloid-derived suppressor cells (MDSCs) subsets in peripheral blood of patients with non-small cell lung cancer (NSCLC).
Methods: 50 cases of NSCLC (NSCLC group) diagnosed in Chest Hospital of Jiangxi Province were selected as the research subjects, and 50 healthy subjects who underwent physical examination in our hospital during the same period were selected as the healthy control group. The expression of HLA-DR-CD14-CD33 MDSCs in peripheral blood mononuclear cells and tumor tissue single cell suspension of NSCLC patients before and after thymalfasin treatment was explored by flow cytometry.
Article Synopsis
- The study investigates the immune microenvironment in head and neck squamous cell carcinoma (HNSCC) to better understand the low response rates (13%-18%) to PD-1 checkpoint inhibitors among patients.
- Using flow cytometry and single-cell RNA sequencing on tumor samples, researchers discovered that immune cell composition varies significantly across different anatomical sites of HNSCC, particularly noting that oral cavity tumors have higher T cell infiltrates.
- Results indicated a strong link between high percentages of PD-1+ T cells, especially in larynx tumors, and improved overall survival, emphasizing the role of T cell presence and PD-1 expression in influencing patient outcomes.