Publications by authors named "Changlei Han"
We aim to understand the varicella-zoster virus (VZV) antibody levels in children after vaccination and to construct VZV-IgG centile curves and reference values for children aged 1-7 years. From September to October 2023, a total of 806 children were recruited according to the time intervals of 1 month, 6 months, 1 year, 2 years, and 3 years after vaccination, as well as age groups. A generalized additive model for location, shape, and scale (GAMLSS) was applied to estimate P, P, P, P, P, P, and P centile reference values of VZV-IgG, and 95% reference intervals were calculated.
View Article and Find Full Text PDFPrunus mume (mei), which was domesticated in China more than 3,000 years ago as ornamental plant and fruit, is one of the first genomes among Prunus subfamilies of Rosaceae been sequenced. Here, we assemble a 280M genome by combining 101-fold next-generation sequencing and optical mapping data. We further anchor 83.
View Article and Find Full Text PDFFoxtail millet (Setaria italica), a member of the Poaceae grass family, is an important food and fodder crop in arid regions and has potential for use as a C(4) biofuel. It is a model system for other biofuel grasses, including switchgrass and pearl millet. We produced a draft genome (∼423 Mb) anchored onto nine chromosomes and annotated 38,801 genes.
View Article and Find Full Text PDFArticle Synopsis
- - The study addresses challenges in de novo genome assembly using next-generation sequencing (NGS) and introduces SOAPdenovo2 as an improved version of the previous software, aiming for better accuracy and efficiency, especially in assembling complex repeat regions.
- - SOAPdenovo2 features a new algorithm that enhances memory usage, increases coverage and assembly length, and provides better results in gap closing and handling large genomes compared to its predecessor.
- - Benchmarks show that SOAPdenovo2 significantly outperforms the original SOAPdenovo and is competitive with other assemblers, showcasing major improvements in the assembly of the Asian (YH) genome with much longer contigs and scaffolds and higher genome coverage.
The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death.
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