Mapping global evidence of caregiver experiences in bipolar disorder in low and middle-income countries: A scoping review.

Background: Bipolar disorder (BD) imposes significant social, psychological, and economic burdens on individuals and their caregivers. While developing treatments for BD patients is crucial, supportive interventions for caregivers in low- and middle-income countries (LMICs) are equally important, given the limited resources and healthcare infrastructure. Understanding caregiver experiences in these settings is essential for creating effective interventions.

Tuberostemonine may enhance the function of the SLC7A11/glutamate antiporter to restrain the ferroptosis to alleviate pulmonary fibrosis.

Ethnopharmacological Relevance: Stemona is a medicinal plant that has been used in China for thousands of years to treat respiratory diseases such as cough and tuberculosis. The tuberostemonine is the component of the Stemona tuberosa Lour., Stemona sessilifolia (Miq.

Laser operation at 1.2 µm in Ho-doped ZBYA glass fibers.

Powerful 1.2-µm laser operation was produced in Ho-doped single-cladding, in-house fabricated ZrF-BaF-YF-AlF (ZBYA) glass fibers. The fibers were fabricated based on ZBYA glass with a composition of ZrF-BaF-YF-AlF.

Bufei Decoction Improves Lung-Qi Deficiency Syndrome of Chronic Obstructive Pulmonary Disease in Rats by Regulating the Balance of Th17/Treg Cells.

Bufei decoction (BFD) has been applied to treat chronic obstructive pulmonary disease (COPD) for centuries as a recognized traditional Chinese herbal formula. However, mechanisms of BFD on COPD are unclear. This study conducts an inquiry into the underlying mechanisms of the therapeutic effect of BFD on COPD.

Two-watt mid-infrared laser emission in robust fluorozirconate fibers.

To the best of our knowledge, we report here the first demonstration of 2.9 µm laser emission from in-house fabricated Ho/Pr co-doped ZBYA glass fiber. The fiber was fabricated based on the ZBYA glass with compositions of ZrF-BaF-YF-AlF-PbF-HoF-PrF.

Significance of the viral load of high-risk HPV in the diagnosis and prediction of cervical lesions: a retrospective study.

Background: The significance of HPV viral load in the detection of cervical lesions is still controversial. This study analyzed the correlation between the high-risk HPV viral load and different cervical lesion degrees.

Methods: This retrospective study included women positive for high-risk HPV DNA and screened for cervical lesions between 01/2015 and 06/2018.

Author Correction: Winter-to-summer seasonal migration of microlithic human activities on the Qinghai-Tibet Plateau.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Winter-to-summer seasonal migration of microlithic human activities on the Qinghai-Tibet Plateau.

The Qinghai-Tibet Plateau (QTP) has become a valuable site for investigation of adaptive regimes of prehistoric humans to extreme environments. At present most studies have focused solely on a single site. Using a more integrated approach that covers the complete scope of the plateau is needed to better understand the expansion logic of prehistoric humans moving towards the plateau.

Simulating the route of the Tang-Tibet Ancient Road for one branch of the Silk Road across the Qinghai-Tibet Plateau.

As the only route formed in the inner Qinghai-Tibet plateau, the Tang-Tibet Ancient Road promoted the extension of the Overland Silk Roads to the inner Qinghai-Tibet plateau. Considering the Complex geographical and environmental factors of inner Qinghai-Tibet Plateau, we constructed a weighted trade route network based on geographical integration factors, and then adopted the principle of minimum cost and the shortest path on the network to simulate the ancient Tang-Tibet Ancient Road. We then compared the locations of known key points documented in the literature, and found a significant correspondence in the Qinghai section.

Chlamydia trachomatis and mycoplasma infections in tubal pregnancy.

Chlamydia trachomatis (CT) infection is an important factor for tubal pregnancy. However, whether Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) infections are also involved in tubal pregnancy remains unknown. This study is aimed to detect CT, UU, and MH in cervical secretions from patients with tubal pregnancy and control women in early pregnancy, to explore their prevalence rates and drug susceptibilities.

Human papillomavirus and human telomerase RNA component gene in cervical cancer progression.

This study aimed to examine hTERC gene in different grades of cervical intraepithelial neoplasia (CIN) and cervical cancer, and the association between hTERC and high risk-human papillomavirus (HR-HPV) infection. Patients who underwent cervical cancer screening at the Second Affiliated Hospital of Kunming Medical University between October 2010 and December 2011 were enrolled. All patients underwent liquid-based cytology test and hybrid capture 2 (HC2) for HPV detection.

HPV infection screening using surface plasmon resonance in women from Kunming (Southwest China).

No study examined the frequency of human papillomavirus (HPV) genotypes by surface plasmon resonance (SPR) in Southwest China. This was a cross-sectional survey (The Second Affiliated Hospital of Kunming Medical University, 10/2010 to 12/2011) in 150 patients who were hospitalized or volunteered for cervical cancer (CC) screening. A HPV typing kit was used to detect 24 types of HPV by the SPR technique.

A Large-Scale Serological Survey of Infection Among Persons Participated in Health Screening in Yunnan Province, Southwestern China.

Surveys of infection in animals have been reported in Yunnan province, southwestern China. However, limited information is available regarding the epidemiology of infection among persons participated in health screening in Yunnan. From January 2014 to December 2016, a large-scale and cross-sectional serological survey was conducted to reveal the seroprevalence of infection in persons participated in health screening in three major hospitals.

MicroRNA-214 Suppresses Ovarian Cancer by Targeting β-Catenin.

Background/aims: Ovarian cancer is one of the most common malignancies with a high rate of mortality in women. However, current therapies for ovarian cancer treatment are ineffective. Therefore, novel target identification is an urgent requisite.

Increased Expression of T Cell Immunoglobulin and Mucin Domain 3 on CD14 Monocytes Is Associated with Systemic Inflammatory Reaction and Brain Injury in Patients with Spontaneous Intracerebral Hemorrhage.

Objective: To study the expression of T cell immunoglobulin and mucin domain 3 (Tim-3) on peripheral blood immunocytes, and the relationship between Tim-3 and the systemic inflammatory response or brain injury in patients with intracerebral hemorrhage (ICH).

Methods: According to the volume of hematoma at 12 hours after onset of ICH, 60 newly diagnosed patients with ICH were divided into the small (volume of hematoma <30 mL, 30 cases) and large (volume of hematoma ≥30 mL, 30 cases) ICH groups. The expression of Tim-3 on peripheral blood immunocytes was analyzed by flow cytometry.

Effects of 2,5-hexanedione on angiogenesis and vasculogenesis in chick embryos.

n-Hexane is widely used in industry and its metabolite, 2,5-hexanedione (2,5-HD), has been implicated as a neural toxin in the developing fetus. Using the chick embryo model, we have previously revealed the neurotoxicity of 2,5-HD during development and established that high dose of 2,5-HD was embryo lethal. In view of the close linkage in biology for neurogenesis and angiogenesis, we speculated that it was most likely caused by cardiovascular dysplasia, therefore in this study, we investigated the effects of 2,5-HD on the development of the vasculature, which involves vasculogenesis and angiogenesis.

Increased expression of T cell immunoglobulin and mucin domain 3 aggravates brain inflammation via regulation of the function of microglia/macrophages after intracerebral hemorrhage in mice.

Background: Microglia/macrophages are known to play important roles in initiating brain inflammation after spontaneous intracerebral hemorrhage (ICH). T cell immunoglobulin and mucin domain-3 (Tim-3) have been proven to play a critical part in several inflammatory diseases through regulation of both adaptive and innate immune responses. Tim-3 can be expressed by microglia/macrophages and regulates their function in the innate immune response.

Traumatic subdural hydroma developing into chronic subdural hematoma.

Objective: To probe the incidence, pathogenesis and clinical characteristics of traumatic subdural hydroma (TSH) developing into chronic subdural hematoma (CSDH).

Methods: We retrospectively analyzed the clinical data of 32 patients with TSH developing into CSDH and reviewed related literature.

Results: 16.