Efficacy and safety of a novel TKI (anlotinib) for the treatment of advanced digestive system neoplasms: a systematic review and meta-analysis.

Objective: To systematically evaluate the efficacy and safety of anlotinib targeted therapy for the treatment of patients with advanced digestive system neoplasms (DSNs).

Methods: Clinical trials were extracted from PubMed, the Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure (CNKI) and the Wanfang database up to October 2023. Outcome measures, including therapeutic efficacy, quality of life (QOL) and adverse events, were extracted and evaluated.

Combined treatment of umbilical cord Wharton's jelly-derived mesenchymal stem cells and platelet-rich plasma for a surgical patient with hospital-acquired pressure ulcer: a case report and literature review.

Hospital-acquired pressure ulcers (HAPUs) are still an important worldwide issue related to the safety and quality of patient care, which are among the top five adverse events reported. Patients who develop HAPUs have longer stays in the hospital than necessary, are at a greater risk of infections, and are more likely to die. Surgical patients are prone to developing PUs because they often remain immobile for extended periods of time, and their surgical procedures may limit the flow of blood oxygen and nutrition and lead to a decrease in muscle tone.

LncRNA HOXA-AS3 promotes cell proliferation and invasion via targeting miR-218-5p/FOXP1 axis in osteosarcoma.

Osteosarcoma is an aggressive form of bone cancer and affects the health in children and adolescents. Although conventional treatment improves the osteosarcoma survival, some patients have metastasis and drug resistance, leading to a worse prognosis. Therefore, it is necessary to explore the molecular mechanism of osteosarcoma occurrence and progression, which could discover the novel treatment for osteosarcoma.

Synergistic etching of nickel foam by Fe and Cl ions to synthesize nickel-iron-layered double hydroxide nanolayers with abundant oxygen vacancies for superior urea oxidation.

Urea electrolysis is an appealing topic for hydrogen production due to its ability to extract hydrogen at a lower potential. However, it is plagued by sluggish kinetics and noble-metal catalyst requirements. Herein, we developed nickel-iron-layered double hydroxide (NiFe-LDH) nanolayers with abundant oxygen vacancies (O) via synergistically etching nickel foam with Fe and Cl ions, enabling the efficient conversion of urea into H and N.

Synergistic catalysis of TiO/WO photoanode and Sb-SnO electrode with highly efficient ClO• generation for urine treatment.

Urine is the major source of nitrogen pollutants in domestic sewage and is a neglected source of H. Although ClO• is used to overcome the poor selectivity and slow kinetics of urea decomposition, the generation of ClO• suffers from the inefficient formation reaction of HO• and reactive chlorine species (RCS). In this study, a synergistic catalytic method based on TiO/WO photoanode and Sb-SnO electrode efficiently producing ClO• is proposed for urine treatment.

Enhanced nitrogen removal via partial nitrification/denitrification coupled Anammox using three stage anoxic/oxic biofilm process with intermittent aeration.

Pre-capturing organics in municipal wastewater for biogas production, combined with Anammox-based nitrogen removal process, improves the sustainability of sewage treatment. Thus, enhancing nitrogen removal via Anammox in mainstream wastewater treatment becomes very crucial. In present study, a three-stage anoxic/oxic (AO) biofilm process with intermittent aeration was designed to strengthen partial nitrification/denitrification coupling Anammox (PNA/PDA) in treatment of low C/N wastewater, which contained chemical oxygen demand (COD) of 79.

Therapeutic utility of human umbilical cord-derived mesenchymal stem cells-based approaches in pulmonary diseases: Recent advancements and prospects.

Pulmonary diseases across all ages threaten millions of people and have emerged as one of the major public health issues worldwide. For diverse disease conditions, the currently available approaches are focused on alleviating clinical symptoms and delaying disease progression but have not shown significant therapeutic effects in patients with lung diseases. Human umbilical cord-derived mesenchymal stem cells (UC-MSCs) isolated from the human UC have the capacity for self-renewal and multilineage differentiation.

Long non-coding RNA Linc00657 up-regulates Skp2 to promote the progression of cervical cancer through lipid reprogramming and regulation of immune microenvironment.

More and more evidence shows that long non-coding RNA (lncRNA) plays an important role in the biological behavior of many kinds of malignant tumors, but the specific function of lncRNA Linc00657 in cervical cancer is still unknown. The purpose of this study is to explore the effect of Linc00657 on the malignant progression of cervical cancer and its potential mechanism. In two kinds of cervical cancer cell lines and normal cervical epithelial cells, qRT-PCR showed increased expression of Linc00657 in cervical cancer cells.

CBX7 is involved in the progression of cervical cancer through the ITGβ3/TGFβ1/AKT pathway.

The chromobox protein homolog 7 (CBX7) serves a tumor-suppressive role in human malignant neoplasias. The downregulation of CBX7 is associated with the poor prognosis and aggressiveness of various human cancers. However, the biological functions and underlying mechanisms of CBX7 in cervical cancer remain unclear.

Enhanced •Cl generation by introducing electrophilic Cu(II) in CoO anode for efficient total nitrogen removal with hydrogen recovery in urine treatment.

Urine is a nitrogen-containing waste, but can be used as an attractive alternative substrate for H recovery. However, conventional urea oxidation reaction is subject to complex six-electron transfer kinetics and requires alkaline conditions. Herein, an efficient method of enhancing •Cl generation by introducing electrophilic Cu(II) into CoO nanowires anode was proposed, which realized the highly efficient TN removal and H production in urine treatment under neutral conditions.

Highly-efficient natural gas desulfurization and simultaneous HO synthesis based on the electrochemical coupling reaction strategy.

Hydrogen sulfide (HS) generated by natural gas exploitation is a dangerous and harmful gas that needs to be purified. Electrochemical Natural Gas Desulfurization offers a promising way for HS purification and resource utilization in ambient conditions. However, poor energy efficiency and low resource value limit the prospective application in the industry.

Predation preference for extracellular polysaccharides by paramecia and rotifers may have accelerated the decline of membrane biofilm hydraulic resistance.

The hydraulic resistance of biofilm layer on membranes impacts the filtration resistance significantly. The effect of predation by two model microfauna (i.e.

Assessing the quality and making appropriate use of historical negative control data: A report of the International Workshop on Genotoxicity Testing (IWGT).

Historical negative control data (HCD) have played an increasingly important role in interpreting the results of genotoxicity tests. In particular, Organisation for Economic Co-operation and Development (OECD) genetic toxicology test guidelines recommend comparing responses produced by exposure to test substances with the distribution of HCD as one of three criteria for evaluating and interpreting study results (referred to herein as "Criterion C"). Because of the potential for inconsistency in how HCD are acquired, maintained, described, and used to interpret genotoxicity testing results, a workgroup of the International Workshops for Genotoxicity Testing was convened to provide recommendations on this crucial topic.

Nitrogen-containing wastewater fuel cells for total nitrogen removal and energy recovery based on Cl•/ClO• oxidation of ammonia nitrogen.

The excess nitrogen discharge into water bodies has resulted in extensive water pollution and human health risks, which has become a critical global issue. Moreover, nitrogenous wastewater contains considerable chemical energy contributed by organic pollutants and nitrogenous compounds. Therefore, the treatment of various kinds of nitrogen-containing wastewater for nitrogen removal and energy recovery is of significance.

Ni doped amorphous FeOOH layer as ultrafast hole transfer channel for enhanced PEC performance of BiVO.

Bismuth vanadate (BiVO), as the potential and prospective photocatalyst, has been limited by the issue of poor separation and transfer of charge carrier for photoelectrocatalytic (PEC) water oxidation. Here, a significant increase of surface injection efficiency for BiVO is realized by the rationally designed Ni doped FeOOH (Ni:FeOOH) layer growing on BiVO photoanode (Ni:FeOOH/BiVO), in which doped Ni can induce partial-charge of FeOOH to serve as ultrafast transfer channel for hole transfer and transportation at the semiconductor/electrolyte interface. In addition, the Ni:FeOOH/BiVO shows the η value of 81.

Unconventional Substitution for BiVO to Enhance Photoelectrocatalytic Performance by Accelerating Polaron Hopping.

Bismuth vanadate (BiVO) as a fascinating semiconductor for photoelectrocatalytic (PEC) water oxidation with suitable band gap () has been limited by the issue of poor separation and transportation of charge carriers. Herein, we propose an unconventional substitution of V sites by Ti in BiVO (Ti:BiVO) for the similar ionic radii and accelerated polaron hopping. Ti:BiVO increased the photocurrent density 1.

Quinoline is more genotoxic than 4-methylquinoline in hiHeps cells and rodent liver.

Environmental pollutants, such as quinoline (QN) and 4-methylquinoline (4-MeQ), may be genotoxic and carcinogenic. Earlier studies, including in vitro genotoxicity tests, indicated that 4-MeQ is more mutagenic than QN. However, we hypothesized that the methyl group of 4-MeQ favors detoxication over bioactivation, and this factor may be overlooked in in vitro tests that do not incorporate supplementation with cofactors for enzymes that catalyze conjugation reactions.

Facile, Controllable, and Ultrathin NiFe-LDH In Situ Grown on a Ni Foam by Ultrasonic Self-Etching for Highly Efficient Urine Conversion.

As the primary source of nitrogen pollutants in domestic sewage, urine is also an alternative for H production via electrochemical processes. However, it suffers from sluggish kinetics and noble-metal catalyst requirement. Here, we report a non-precious ultrathin NiFe-layered double hydroxide catalyst for the remarkable conversion of urea into N and H, which is in situ grown on a Ni foam via ultrasonic self-etching in Fe/ethylene glycol (EG).

Type-II Heterojunction CdInS/BiVO Coupling with CQDs to Improve PEC Water Splitting Performance Synergistically.

Bismuth vanadate (BiVO) has been considered as a promising photoelectrocatalytic (PEC) semiconductor, but suffers from severe hole recombination, attributed to the short hole-diffusion length and the low carrier mobility. Herein, a type-II heterojunction CdInS/BiVO is designed to improve the photocurrent density from 1.22 (pristine BiVO) to 2.

LncRNA SCAMP1 disrupts the balance between miR-26a-5p and ZEB2 to promote osteosarcoma cell viability and invasion.

Osteosarcoma often occurs in children and adolescents and affects their health. The survival rate of osteosarcoma patients is unsatisfactory due to the lack of early detection and metastasis development and drug resistance. Hence, dissection of molecular insight into osteosarcoma initiation and progression is pivotal to provide the new therapeutic strategy.

Rapid Conversion of Co to Co by Introducing Oxygen Vacancies in CoO Nanowire Anodes for Nitrogen Removal with Highly Efficient H Recovery in Urine Treatment.

Urine is a nitrogenous waste biomass but can be used as an appealing alternative substrate for H recovery. However, urine electrolysis suffers from sluggish kinetics and requires alkaline condition. Herein, we report a novel system to decompose urine to H and N under neutral conditions mediated by Cl using oxygen-vacancy-rich CoO nanowire (O-CoO) anodes and CuO nanowire cathodes.

Novel Denitrification Fuel Cell for Energy Recovery of Nitrate-N and TN Removal Based on NH Generation on a CNW@CF Cathode.

NO is an undesirable environmental pollutant that causes eutrophication in aquatic ecosystems, and its pollution is difficult to eliminate because it is easily converted into NH instead of N. Additionally, it is a high-energy substance. Herein, we propose a novel denitrification fuel cell to realize the chemical energy recovery of NO and simultaneous conversion of total nitrogen (TN) into N based on the outstanding ability of NH generation on a three-dimensional copper nanowire (CNW)-modified copper foam (CF) cathode (CNW@CF).

Treatment of hazardous organic amine wastewater and simultaneous electricity generation using photocatalytic fuel cell based on TiO/WO photoanode and Cu nanowires cathode.

Organic amines are regarded as high toxic, refractory chemicals due to the great damage on human body, and ecosystem. The treatment of organic amine wastewater involves the removal of total nitrogen and toxic organics simultaneously, which is one of the biggest difficulties in wastewater treatment. In this study, hazardous organic amine wastewater was purified by a photocatalytic fuel cell (PFC) with efficient nitrogen removal and organic degradation, and its chemical energy was recovered simultaneously based on hydroxyl radical (HO·) and chlorine radical (Cl·) reaction in a novel TiO/WO and 3D Cu nanowires modified Cu foam (CuNWs/CF) system.