Publications by authors named "Changhong He"

Isoorientin (ISO), a flavone C-glycoside, is a glycogen synthase kinase 3β (GSK3β) substrate-competitive inhibitor. ISO has potential in treatment of Alzheimer's disease (AD). An excessive activation of GSK3β can lead to neuroinflammation causing neuronal damage.

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Article Synopsis
  • Alzheimer's disease (AD) is a neurodegenerative disorder linked to oxidative stress, and the compound TFGF-18 shows promise by inhibiting GSK-3β, a potential therapeutic target for AD.
  • The study assessed TFGF-18's neuroprotective effects against oxidative stress in both lab-grown rat cells and scopolamine-induced AD mice, measuring various biochemical and behavioral responses.
  • Results indicated that TFGF-18 reduces neuronal damage, decreases oxidative stress markers, and enhances protective protein expressions, suggesting it may be beneficial for treating AD.
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Background: LncRNA MSC-AS1 has been reported to be a tumor promoter in hepatocellular carcinoma. However, the function of MSC-AS1 in colorectal cancer (CRC) has not been elucidated. It is designed to study the expression level of MSC-AS1 and investigate its biological effect on the progression of CRC.

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We study the relationship between the step angles and the accuracy of north finding with fiber optic gyroscopes. A north-finding method with optimized step angles is proposed to reduce the errors caused by rate random walk (RRW). Based on this method, the errors caused by both angle random walk and RRW are reduced by increasing the number of positions.

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We present an enhanced multiposition method (EMM) to suppress the north finding error caused by bias drift with fiber optic gyroscopes (FOGs). The new proposal is a static method to find the true north, and it employs a differential strategy and a rotation scheme of increasing step angle. Using the noise model of Allan variance, we analyze the north finding errors caused by angle random walk (ARW), rate random walk (RRW), and rate ramp (RR) theoretically, where RRW and RR are two main noise sources of bias drift, and ARW is the rate white noise.

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We propose a simple and, to our knowledge, novel method for suppressing the bias drift of interferometric all-fiber optic gyroscopes (I-FOGs) and for self-calibrating the bias of I-FOGs to zero. Using a square wave to reverse the polarity of the sinusoidal voltage on a piezoelectric (PZT) modulator periodically, and calculating the output signal of a demodulator circuit in-phase with the square wave by a digital signal processor (DSP), we successfully reduce the bias drift of I-FOGs. Experimental results show that, at room temperature, the proposed method dramatically reduces the bias instability of an I-FOG from 0.

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