Neuroprotection of isoorientin against microglia activation induced by lipopolysaccharide via regulating GSK3β, NF-κb and Nrf2/HO-1 pathways.

Isoorientin (ISO), a flavone C-glycoside, is a glycogen synthase kinase 3β (GSK3β) substrate-competitive inhibitor. ISO has potential in treatment of Alzheimer's disease (AD). An excessive activation of GSK3β can lead to neuroinflammation causing neuronal damage.

LncRNA MSC-AS1 Promotes Colorectal Cancer Progression by Regulating miR-325/TRIM14 Axis.

Background: LncRNA MSC-AS1 has been reported to be a tumor promoter in hepatocellular carcinoma. However, the function of MSC-AS1 in colorectal cancer (CRC) has not been elucidated. It is designed to study the expression level of MSC-AS1 and investigate its biological effect on the progression of CRC.

Step angles to reduce the north-finding error caused by rate random walk with fiber optic gyroscope.

We study the relationship between the step angles and the accuracy of north finding with fiber optic gyroscopes. A north-finding method with optimized step angles is proposed to reduce the errors caused by rate random walk (RRW). Based on this method, the errors caused by both angle random walk and RRW are reduced by increasing the number of positions.

Enhanced multiposition method to suppress the north finding error caused by bias drift with fiber optic gyroscopes.

We present an enhanced multiposition method (EMM) to suppress the north finding error caused by bias drift with fiber optic gyroscopes (FOGs). The new proposal is a static method to find the true north, and it employs a differential strategy and a rotation scheme of increasing step angle. Using the noise model of Allan variance, we analyze the north finding errors caused by angle random walk (ARW), rate random walk (RRW), and rate ramp (RR) theoretically, where RRW and RR are two main noise sources of bias drift, and ARW is the rate white noise.

Method for suppressing the bias drift of interferometric all-fiber optic gyroscopes.

We propose a simple and, to our knowledge, novel method for suppressing the bias drift of interferometric all-fiber optic gyroscopes (I-FOGs) and for self-calibrating the bias of I-FOGs to zero. Using a square wave to reverse the polarity of the sinusoidal voltage on a piezoelectric (PZT) modulator periodically, and calculating the output signal of a demodulator circuit in-phase with the square wave by a digital signal processor (DSP), we successfully reduce the bias drift of I-FOGs. Experimental results show that, at room temperature, the proposed method dramatically reduces the bias instability of an I-FOG from 0.