Molecular mechanism of the anti-inflammatory and skin protective effects of in human skin keratinocytes.

Unlabelled: Irradiation injury, especially caused by UVB, of the skin is one of the critical reasons for skin inflammation and damage. The present study aimed to explore the protective effect of leafy extract (SFLE) and its mechanism of action against UVB-induced damages of human keratinocytes. In this study, SFLE was prepared from 100 kg dried leaves using industrial-scale processes.

Precise Filtration of Chronic Myeloid Leukemia Cells by an Ultrathin Microporous Membrane with Backflushing to Minimize Fouling.

A cell filtration platform that affords accurate size separation and minimizes fouling was developed. The platform features an ultra-thin porous membrane (UTM) filter, a pumping head filtration with backflush (PHF), and cell size measurement (CSM) software. The UTM chip is an ultrathin free-standing membrane with a large window area of 0.

Depth Cube-Based Six Degree-of-Freedom Haptic Rendering for Rigid Bodies.

This paper presents a depth image-based six degree-of-freedom (6-DOF) haptic rendering method for rigid bodies. In order to increase the collision detection speed, a depth cube structure is developed, consisting of six-sided orthogonal depth images extracted from six virtual depth cameras located around and fixed with respect to the virtual object. With the depth cube and a set of sample points for the tool object, a quick point-in-object test can be performed.

NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutants.

The MET proto-oncogene product, which is the receptor for hepatocyte growth factor (HGF), has been implicated in tumorigenesis and metastatic progression. Point mutations in MET lead to the aberrant activation of the receptor in many types of human malignancies, and the deregulated activity of MET has been correlated with tumor growth, invasion, and metastasis. MET has therefore attracted considerable attention as a potential target in anticancer therapy.