[Simultaneous determination of 14 mycotoxins in Bombyx Batryticatus and Eupolyphaga Steleophaga by QuEChERS combined with UPLC-MS/MS].

A method for simultaneous determination of multiple mycotoxins in Bombyx Batryticatus and Eupolyphaga Steleophaga was established to provide technical support for monitoring and quality control of such medicinal materials. The mildew-prone Bombyx Batryticatus and Eupolyphaga Steleophaga were detected by UPLC-MS/MS technology, and the chromatographic conditions, mass spectrometry conditions, test sample preparation methods, and QuEChERS purification parameters were optimized. Scanning was conducted under multiple reaction monitoring mode(MRM), and quantitative analysis was performed by matrix standard curve method.

Simulation of distribution in China: assessing habitat suitability and bioactive component abundance under future climate change scenariosplant components.

Background: is used in traditional Chinese medicine, so ensuring an adequate supply of plant material with high levels of bioactive components is important.

Methods: Using an optimized maximum entropy niche model and assays of bioactive components from cultivation samples, this study started from the plant's natural distribution area and estimated correlations of ecological factors with not only abundance of the plant but also abundance of polysaccharides and heterophyllin B. These correlations were combined with the spatial analysis function in ArcGIS to generate maps of the suitability of different habitats in China for cultivating under current climate conditions and different models of climate change.

Identifying the quality markers and optimizing the processing of Gastrodiae rhizoma to treat brain diseases.

Background: Gastrodiae rhizoma (GR) refers to the dried tuber of Bl. and has been used for many centuries to treat brain diseases, such as Alzheimer's disease, major depressive disorder, and cerebral ischemia. However, the processing of GR is complex and varied, resulting in unstable clinical treatment effects.

Ardisia Crispae Radix et Rhizoma: A review of botany, traditional uses, phytochemistry, pharmacology, and toxicology.

Ethnopharmacological Relevance: Ardisia Crispae Radix et Rhizoma comprises three primary source plants: Ardisia crenata Sims, Ardisia crispa (Thunb.) A. DC.

Identification and characterization of Morganella morganii strain YC12-C3 and Enterococcus faecalis strain YC12-C10 and elucidation of its deoxynivalenol-degrading potential.

Deoxynivalenol ( DON) is one of the most harmful mycotoxins in food or feed or Traditional Chinese Medicine. An efficient and applicable method for the detoxification of DON is urgently developed. 1152 strains were isolated from the intestinal contents of crucian.

Contamination of the traditional medicine Radix Dipsaci with aflatoxin B1 impairs hippocampal neurogenesis and cognitive function in a mouse model of osteoporosis.

Background: Aflatoxin B1, which can penetrate the blood-brain barrier and kill neural cells, can contaminate traditional herbal medicines, posing a significant risk to human health. The present study examined cellular, cognitive and behavioral consequences of aflatoxin B1 contamination of the anti-osteoporotic medicine Radix Dipsaci.

Methods: A mouse model of osteoporosis was created by treating the animals with all-trans-retinoic acid.

A 2m-Range 711μW Body Channel Communication Transceiver Featuring Dynamically-Sampling Bias-Free Interface Front End.

Body Channel Communication (BCC) utilizes the body surface as a low-loss signal transmission medium, reducing the power consumption of wireless wearable devices. However, the effective communication range on the human body is limited in the state-of-the-art BCC transceivers, where the signal loss between the body surface and the BCC receiver remains one of the main bottlenecks. To reduce the interface loss, a high input impedance is desired by the BCC receiver, but the DC-biasing circuits decrease the input impedance.

Neural Dielet 2.0: A 128-Channel 2mm×2mm Battery-Free Neural Dielet Merging Simultaneous Multi-Channel Transmission through Multi-Carrier Orthogonal Backscatter.

Miniaturization of wireless neural-recording systems enables minimally-invasive surgery and alleviates the rejection reactions for implanted brain-computer interface (BCI) applications. Simultaneous massive-channel recording capability is essential to investigate the behaviors and inter-connections in billions of neurons. In recent years, battery-free techniques based on wireless power transfer (WPT) and backscatter communication have reduced the sizes of neural-recording implants by battery eliminating and antenna sharing.

Composition and diversity of soil microbial communities change by introducing Phallus impudicus into a Gastrodia elata Bl.-based soil.

Background: The Gastrodia elata Bl. is an orchid, and its growth demands the presence of Armillaria species. The strong competitiveness of Armillaria species has always been a concern of major threat to other soil organisms, thus disrupting the equilibrium of soil biodiversity.

Quality evaluation and identification of bleached with sodium metabisulfite based on whole spectrum metabolomics.

(HC) is a widely distributed plant in Asia and is used extensively for both food and medicinal purposes. A preliminary investigation found that HC is often bleached with sodium metabisulfite solution during its field processing, leading to health risks. In this study, the effects of sodium metabisulfite on the quality of HC were comprehensively evaluated using volatile and non-volatile targeted metabolomic methods.

A Probiotic D-1 Strain Is Responsible for Zearalenone Detoxifying in Coix Semen.

Zearalenone (ZEN) is a mycotoxin produced by spp., which commonly and severely contaminate food/feed. ZEN severely affects food/feed safety and reduces economic losses owing to its carcinogenicity, genotoxicity, reproductive toxicity, endocrine effects, and immunotoxicity.

Effect of symbiotic fungi- on the yield of Bl. and insight into the response of soil microbial community.

members play important roles in the nutrient supply and growth modulation of Bl., and they will undergo severe competition with native soil organisms before colonization and become symbiotic with . Unraveling the response of soil microbial organisms to symbiotic fungi will open up new avenues to illustrate the biological mechanisms driving 's benefit from .

Metabolomic and microbiomic insights into color changes during the sweating process in .

Sweating is one of the most important primary processing methods of Chinese medicinal materials. is a typical representative of sweating treatment that is recommended by the Chinese Pharmacopoeia. The color change of the fracture surface of the root is the prominent feature of sweating treatment.

A Self-Adaptive Dual-ILRO Clock-Recovery Technique for Two-Tone Battery-Free Crystal-Free Neural-Recording SoC.

Wireless implantable devices are widely used in medical treatment, which should meet clinical constraints such as longevity, miniaturization, and reliable communication. Wireless power transfer (WPT) can eliminate the battery to reduce system size and prolong device life, while it's challenging to generate a reliable clock without a crystal. In this work, we propose a self-adaptive dual-injection-locked-ring-oscillator (dual-ILRO) clock-recovery technique based on two-tone WPT and integrate it into a battery-free neural-recording SoC.

[Common diseases and drug use of Pseudostellaria heterophylla].

Pseudostellaria heterophylla in large-scale cultivation needs to apply pesticides to control diseases, and non-standard use of pesticide may cause excessive pesticide residues in medicinal materials, increasing the risk of clinical medication. To accurately monitor the residual pesticides, this paper investigated the drug use during the process of P. heterophylla disease prevention in 25 P.

[Common diseases and drug use characteristics of Chinese herbal medicines and suggestions].

Based on the data of 56 kinds of diseases and drug use in 100 kinds of cultivated Chinese herbal medicines, this paper used frequency analysis method to count the types of diseases and their drug use characteristics, and systematically analyzed the status of drug registration and monitoring standards for disease prevention and control of Chinese herbal medicines. The results showed that 14 diseases such as root rot, powdery mildew, and drooping disease were common in the production of Chinese herbal medicines. Among the 99 pesticides reported, 67.

Neural Dielet: A 0.4mm Battery-Less Crystal-Less Neural-Recording System on Die Achieving 1.6cm Backscatter Range with 2mm×2mm On-Chip Antenna.

Miniaturization is essential in the design of wireless neural-recording systems. In recent years, the battery in neural-recording systems can be eliminated by wireless power transfer (WPT), while antenna and crystal become two main bottlenecks to minimize a battery-less neural implant. In conventional battery-less designs, the miniaturization of antenna led to a short communication range, and a crystal-less clock suffered from noise issue or power-hungry circuits.

[Contamination status and exposure risk of mycotoxins in Coicis Semen].

By investigating the contamination status and predicting the exposure risk of mycotoxin in Coicis Semen, we aim to provide guidance for the safety supervision of Chinese medicinal materials and the formulation(revision) of mycotoxin limit standards. The content of 14 mycotoxins in the 100 Coicis Semen samples collected from five major markets of Chinese medicinal materials in China was determined by UPLC-MS/MS. The probability evaluation model based on Monte Carlo simulation method was established after Chi-square test and One-way ANOVA of the sample contamination data.

Transcriptome analysis reveals that jasmonic acid biosynthesis and signaling is associated with the biosynthesis of asperosaponin VI in .

is a perennial herb, the roots of which are abundant in asperosaponin VI, which has important medicinal value. However, the molecular mechanism underlying the biosynthesis of asperosaponin VI in remains unclear. In present study, a comprehensive investigation of asperosaponin VI biosynthesis was conducted at the levels of metabolite and transcript during root development.

Volatiles from Strain B-BH16-1 Suppress Aflatoxin Production and Growth of s on during Storage.

Semen coicis is not only a traditional Chinese medicine (TCM), but also a typical food in China, with significant medical and healthcare value. Because semen coicis is rich in starch and oil, it can be easily contaminated with and its aflatoxins (AFs). Preventing and controlling the contamination of semen coicis with and its aflatoxins is vital to ensuring its safety as a drug and as a food.

A Wireless Headstage System Based on Neural-Recording Chip Featuring 315 nW Kickback-Reduction SAR ADC.

Wireless neural-recording instruments eliminate the bulky cables in multi-channel signal transmission, while the system size should be reduced to mitigate the impact on freely-moving animals. As the battery usually dominates the system size, the neural-recording chip should be low power to minimize the battery in long-termly monitoring. In general, a neural-recording chip consists of an analog front end (AFE) and an 8 bit -10 bit analog-to-digital converter (ADC), while it's challenging to design an ADC with an 8 -10 effective number of bits (ENOB) and sub- μ W power consumption due to the kickback noise.

A Power-Harvesting CGM Chiplet Featuring Silicon-Based Enzymatic Glucose Sensor.

Diabetes has become a leading cause of death and disability in the past decades. Continuous glucose monitoring (CGM) is a prevailing technique to determine the glucose level and provide in-time treatment. However, conventional CGM systems combine an electrochemical sensor with a CMOS chip, suffering from bulky size and interface issues.

Soil Microbial Communities Affect the Growth and Secondary Metabolite Accumulation in (Thunb.) Rchb. f.

(Thunb.) Rchb.f.