Publications by authors named "Changgui Guo"
Objective: Spontaneous hypertensive brainstem hemorrhage (HBSH) is characterized by sudden onset, rapid progression and poor prognosis. There has been a growing tendency of surgical treatment for HBSH. This study aimed to investigate outcomes and potential factors associated with the prognosis of robot-assisted drainage surgery for HBSH treatment.
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- - The study explored how dihydroartemisinin affects the growth of chemotherapy-resistant C6 rat glioma cells, finding that treatment significantly reduced cell numbers and DNA synthesis after 48 hours.
- - Treatment with 20 µM dihydroartemisinin resulted in a drastic increase in apoptosis rates among the glioma cells, with 54.78% of cells being apoptotic compared to just 2.57% in untreated controls.
- - Additionally, dihydroartemisinin treatment altered the cell cycle, decreasing cells in the G2/M phase and increasing those in the G0/G1 phase, indicating an overall antitumor effect likely through promoting apoptosis, warranting further investigation in animal models.
In recent years, it has been widely identified that the stromal cell-derived factor 1 (SDF-1) and anterior gradient 2 (AGR2) were implicated in the development of epithelial-mesenchymal transition (EMT) in a variety of cancers. However, the involvement of SDF-1-AGR2 pathway in the EMT of glioblastoma has not been investigated. In the present study, the in vitro assays were used to investigate the role of AGR2 in cell cycle, migration, and invasion.
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