Publications by authors named "Changgao Shi"
Background: The safety and efficacy of transarterial chemoembolization plus molecular targeted therapy (MTT) combined with immune checkpoint inhibitors (ICIs) in primary liver cancer have been demonstrated. However, the evidence for TACE plus MTT combined with ICIs in the treatment of recurrent hepatocellular carcinoma (RHCC) is limited. Given the excellent performance of this combination regimen in primary liver cancer, it is necessary to evaluate the efficacy of TACE plus MTT combined with ICIs in RHCC.
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- Gallbladder carcinoma (GBC) is a serious cancer often diagnosed late, prompting the need for better understanding of its molecular mechanisms for targeted therapies.
- The study investigated the role of long non-coding RNA AFAP1-AS1 in regulating GBC cell growth and death by interacting with microRNA hsa-miR-15a-5p, revealing important findings about cell proliferation and apoptosis.
- Results indicated that AFAP1-AS1 promotes GBC cell growth and reduces apoptosis via hsa-miR-15a-5p, which also targets the bcl-2 protein, suggesting a potential therapeutic pathway for GBC treatment.