CTHRC1 modulates cell proliferation and invasion in hepatocellular carcinoma by DNA methylation.

Background: Collagen triple helix repeat containing-1 (CTHRC1), an extracellular matrix protein, is highly expressed in hepatocellular carcinoma (HCC) and linked to poor prognosis. Nevertheless, the precise mechanism of CTHRC1 in HCC is unclear.

Methods: Agena MassARRAY® Methylation Analysis assessed the methylation level of CTHRC1 in the promoter region.