Ginsenoside Re suppresses high glucose-induced apoptosis of placental trophoblasts through endoplasmic reticulum stress-related CHOP/GADD153.

Gestational diabetes mellitus (GDM) is a metabolic disorder that arises during pregnancy and heightens the risk of placental dysplasia. Ginsenoside Re (Re) may stabilize insulin and glucagon to regulate glucose levels, which may improve diabetes-associated diseases. This study aims to investigate the mechanism of Re in high glucose (HG)-induced apoptosis of trophoblasts through endoplasmic reticulum stress (ERS)-related protein CHOP/GADD153.

[Effect of health education intervention on schistosomiasis control in Mianyang City].

Objective: To evaluate the effect of health education on schistosomiasis control in Mianyang City.

Methods: The population aged 6-65 years in 12 moderately and heavy schistosomiasis endemic villages of 6 endemic counties in Mianyang City were selected as the investigation objects, among which, the health education on schistosomiasis control were implemented. The questionnaire surveys were carried out to understand the knowledge, attitude and behavior on schistosomiasis control of the target population, and the scores before and after the intervention were compared to evaluate the effect.

[Molluscicidal effect of Rongbao in Mianyang City].

Objective: To evaluate the molluscicidal effect of Rongbao in schistosomiasis endemic areas in Mianyang City.

Methods: Three Oncomelania hupensis snail habitats with the similar snail status were selected and sprayed with Rongbao, niclosamide, and fresh water, respectively. Then the snail status in the three fields was surveyed before the spraying and 7, 15, 30 and 60 days after the spraying, and the molluscicidal effects of different molluscicides were compared.

[Assessment of schistosomiasis transmission interruption in Beichuan County, Sichuan Province].

Objective: To assess whether Beichuan County reaches the national standard of schistosomiasis transmission interruption.

Methods: Three villages in Beichuan County were sampled as assessment spots, and the schistosomiasis infections of residents and domestic animals, the status of Oncomelania snails and the past records were assessed according to the Criteria for Control and Elimination of Schistosomiasis in China.

Results: No local schistosome infections were found in residents and cattle for successive 5 years and no snails were found for 2 successive years in the 3 villages.

[Toxicity of 50% ethanol salt powder of niclosamide on growth of silkworms].

Objective: To observe the toxity of niclosamide on the growth of silkworms.

Methods: Mulberry leaves were soaked in the different concentrations of solution of 50% ethanol salt powder of niclosamide for 10 s or 3 min, and then the leaves were fed to silkworms. The death rates of silkworms and the weight of cocoons were observed.

[Investigation on advanced schistosomiasis cases in Mianyang].

Objective: To understand the current status and disease history of advanced cases of schistosomiasis in Mianyang Prefecture.

Methods: The advanced patients in Fucheng, Beichuan and Anxian were investigated in 2010. Demographical information, disease history, current status, awareness and accessibility to the national medical aid to advanced schistosomiasis patients were investigated by inquiry, physical examination and information searching from the history archives.