Publications by authors named "Changdi Chen"
Article Synopsis
- Nephrotic syndrome (NS) is a common kidney condition in children that can lead to severe complications like acute kidney injury (AKI), prompting the need for early identification of high-risk patients.
- A comprehensive analysis of 11 studies showed that AKI occurs in about 29% of children with NS, with several significant risk factors like age of onset, gender, serum albumin levels, steroid response, and existing conditions such as infections and hypertension.
- The study utilized traditional and network meta-analyses to evaluate these risk factors, emphasizing the importance of recognizing these associations to improve management and outcomes for children with NS.
Objective: To investigate whether endothelial nitric oxide synthase () rs1799983, rs2070744, and rs61722009 gene polymorphisms are associated with pulmonary arterial hypertension (PAH) in South Fujian newborns with congenital heart disease (CHD).
Methods: Genotyping for the rs1799983, rs2070744, and rs61722009 polymorphisms was performed using Sanger sequencing in 50 newborns with PAH secondary to CHD [CHD PAH (+)], 52 newborns with CHD without PAH [CHD PAH (-)], and 60 healthy controls.
Results: The genotype and allele frequency distributions of rs1799983, rs2070744, and rs61722009 were similar between CHD and healthy controls ( > .