Complement C5/C5a in the diagnosis and treatment of Graves ophthalmopathy: A Mendelian randomized study.

Objectives: Graves' ophthalmopathy is a complex organ-specific autoimmune disease with an unclear pathogenesis. Complement component 5/5a (C5/C5a), a key element of the component system, may play a significant role in the disease's pathological process. This study aims to investigate the causal relationship between C5/C5a and Graves' ophthalmopathy using Mendelian randomization (MR) to provide new theoretical insights for its diagnosis and treatment.

Identifying major depressive disorder among US adults living alone using stacked ensemble machine learning algorithms.

Background: It has been increasingly recognized that adults living alone have a higher likelihood of developing Major Depressive Disorder (MDD) than those living with others. However, there is still no prediction model for MDD specifically designed for adults who live alone.

Objective: This study aims to investigate the effectiveness of utilizing personal health data in combination with a stacked ensemble machine learning (SEML) technique to detect MDD among adults living alone, seeking to gain insights into the interaction between personal health data and MDD.

Widely targeted metabolomics to analyze the effect of polyvinyl alcohol/pullulan/ZnO-Nps composite film on postharvest storage of Allium mongolicum regel.

In this study, a composite film (CF) made of polyvinyl alcohol, pullulan, and ZnO nanoparticles was prepared by solution casting. The CF were applied to the postharvest preservation of Allium mongolicum Regel. Widely targeted metabolomics analysis of A.

Contrasting diversity patterns between microeukaryotic and prokaryotic communities in cold-seep sediments.

Cold seeps are hotspots of biodiversity. However, the quantification of the microbial diversity, particularly that of microeukaryotes, remains scarce and little is known about the active groups. In this study we investigated the diversity and activity of prokaryotes and microeukaryotes in the Haima cold seep sediments in the northern South China Sea using both DNA (whole community) and RNA (active community) signatures.

Application of Neurophysiological Monitoring and Ultrasound Guidance in Intramedullary Decompression for Acute Spinal Cord Injury.

Objective: To explore the clinical application value of neurophysiological monitoring combined with ultrasound guidance in Acute spinal cord injury.

Methods: Ten patients with acute spinal cord injury underwent intramedullary decompression surgery under neurophysiological monitoring and intraoperative ultrasound guidance. ASIA (American Spinal Injury Association) classification and JOA (Japan Orthopaedic Association) scoring were performed preoperatively and postoperatively.

Resolution enhancement of total internal reflection microscopy via polarised scattering.

This paper presents a novel approach for enhancing the resolution of label-free total internal reflection microscopy. This method leverages the directional difference of the sample polar scattering by capturing microscopic images under the illumination of evanescent waves propagating in various directions. By computing the high-order autocorrelation accumulation of these images at different angles, we achieved a 1.

Analysis of the Relationship Between Rural-Urban Status and Use of Digital Health Technology Among Older Cancer Survivors Based on the Health Information National Trends Survey: Cross-Sectional Analysis.

Background: Though telehealth has been a promising avenue for engaging cancer survivors with health care and lifestyle programming, older and rural-dwelling cancer survivors may have additional challenges in accessing digital devices and tools that have not yet been described. This study aimed to use a robust, nationally representative sample collected in 2022 to provide an updated view of digital technology use and the use of technology for health in this population.

Objective: This study aimed to examine the prevalence of digital technology use for health-related activities among older cancer survivors in both rural and urban settings.

Peripheral Inflammation Profile of Cerebellar Ataxia.

Objectives: The objective of this study is to determine the characteristics of peripheral inflammatory profiles and their correlations with the clinical features in patients with cerebellar ataxia.

Methods: We conducted a cross-sectional study on a cohort of 140 cerebellar ataxia patients, including 74 patients with spinocerebellar ataxia (SCA), 66 patients with multiple system atrophy with predominant cerebellar ataxia (MSA-C), and 145 healthy controls (HCs). Inflammatory profiles (PLT, MPV, NLR, PLR, MLR, SII, AISI and ESR) were measured in peripheral blood, and were compared by ANOVA and Kruskal-Wallis test.

Multiple metabolic analysis of [F]FDG PET/CT in patients with kidney disease.

Purpose: This study aimed to evaluate the value of [F]FDG PET/CT in patients with kidney disease by using multiple metabolic parameters.

Materials And Methods: A retrospective review of 182 kidney disease patients and 32 controls was conducted. Patients were categorized into acute kidney disease (AKD), AKI on CKD (A/C), and chronic kidney disease (CKD) groups, further divided by CKD stage and disease etiology.

Mixed-Supervised Learning for Cell Classification.

Cell classification based on histopathology images is crucial for tumor recognition and cancer diagnosis. Using deep learning, classification accuracy is hugely improved. Semi-supervised learning is an advanced deep learning approach that uses both labeled and unlabeled data.

Draft genome sequences of recovered from organic and conventional retail chickens in Maryland, USA.

We report the draft genome sequences of 94 multidrug-resistant isolates (. Infantis, Enteritidis, and Typhimurium) from organic and conventional retail chickens in Maryland, USA (average genome size = 4.97 Mb; guanine-cytosine content = 52.

Diagnostic and prognostic role of F-FDG PET/CT for sarcomatoid differentiation in renal cell carcinoma.

Background: Sarcomatoid differentiation is an invasive dedifferentiated feature of tumor and associated with poor prognosis in renal cell carcinoma (RCC) patients. This study aimed to evaluate the utility of F-FDG PET/CT in predicting sarcomatoid differentiation in RCC and its potential prognostic value.

Results: This retrospective study assessed newly diagnosed sarcomatoid differentiation renal cell carcinoma (SDRCC) patients who were staged using F-FDG PET/CT.

Multiple Pathways Revealing the CeO Nanoparticle-Biostimulant-Based "Stress Training" Strategy for Enhanced L. Antiviral Capability.

"Nanophytovirology" is a potential management approach to combat plant viral diseases. Herein, the impact of foliar application of CeO nanoparticles (CeO-NPs) on the growth, plant cell ultrastructure, and physiology of alfalfa mosaic virus (AMV)-infected alfalfa seedlings was explored at different concentrations and application strategies. In a solar greenhouse, 20 mL of CeO-NP suspensions of 50, 100, 200, and 500 mg/L was sprayed onto the plant surface every other day for 9 days.

Rational Design of Aqueous Na Ion Batteries Toward High Energy Density and Long Cycle Life.

Prussian blue analogues (PBAs) are promising cathode candidates for aqueous Na ion batteries (ANIBs) considering their low-carbon and cost-effective features. However, it is still a huge challenge to achieve desirable energy density coupled with long cycle life due to inherent Na defects in PBAs and the unstable solid-electrolyte interphase (SEI) layer. Herein, we design NaCO additives as sodium supplements to compensate for Na defects in PBAs, while utilizing the CO products decomposed from NaCO to construct a robust SEI layer containing NaCO species.

Practice and Impact of Using Fall Screening Tools in Emergency Medicine for Older Adults: A Scoping Review.

Falls are a leading cause of injury among older adults in the United States which leads to significant morbidity and mortality. Though screening for fall risk is an important preventative measure in the emergency department (ED), fall screening tools' feasibility and utility remain a challenge in EDs. This scoping review aimed to identify the fall screening tools, their psychometric properties, their best practices, and their impact in the ED among patients aged 60 years and older.

Viscoelastic behavior of wormlike micellar solutions formed by an aspartame-based bicephalous anionic surfactant.

Innovation in the molecular design of surfactants holds great potential for developing novel soft materials with unique properties. A surfactant with a long alkyl tail is expected to form giant aggregates with intriguing behavior. However, molecules with a large hydrophobic group often suffer from poor solubility in solutions, inhibiting the aggregation process.

TRACE Model: Predicting Treatment Response to Transarterial Chemoembolization in Unresectable Hepatocellular Carcinoma.

Purpose: To develop and validate a predictive model for predicting six-month outcome by integrating pretreatment MRI features and one-month treatment response after TACE.

Methods: A total of 108 patients with 160 hCCs from a single-arm, multicenter clinical trial (NCT03113955) were analyzed and served as the training cohort. An external multicenter dataset (ChiCTR2100046020) consisting of 63 patients with 99 hCCs served as the test dataset.

Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs.

Mucosal antigen-specific T cells are pivotal for pathogen clearance and immune modulation in respiratory infections. Dysregulated T cell responses exacerbate coronavirus disease 2019 severity, marked by cytokine storms and respiratory failure. Despite extensive description in peripheral blood, the characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cells in the lungs remain elusive.

Pre-pandemic leukocyte count is associated with severity of post-acute sequelae of SARS-CoV-2 infection among older women in the Women's Health Initiative.

Objective: Although dysregulated inflammation has been postulated as a biological mechanism associated with post-acute sequelae of severe acute respiratory coronavirus 2 (SARS-CoV-2) infection (PASC) and shown to be a correlate and an outcome of PASC, it is unclear whether inflammatory markers can prospectively predict PASC risk. We examined the association of leukocyte count and high-sensitivity C-reactive protein (hsCRP) concentrations, measured ~25 years prior to the coronavirus disease 2019 (COVID-19) pandemic, with PASC, PASC severity, and PASC-associated cognitive outcomes at follow-up among postmenopausal women.

Methods: Using biomarker data from blood specimens collected during pre-pandemic enrollment (1993-1998) and data on 1,237 Women's Health Initiative participants who completed a COVID-19 survey between June 2021 and February 2022, we constructed multivariable regression models that controlled for pertinent characteristics.

SABR tolerance after prostatectomy: pushing the boundaries of ultrahypofractionation.

Objective: To evaluate the feasibility and tolerance of ultra-hypofractionated SABR (stereotactic ablative radiation therapy) protocol following radical prostatectomy.

Patients And Methods: We included patients undergoing adjuvant or salvage SABR between April 2019 and April 2023 targeting the surgical bed and pelvic lymph nodes up to a total dose of 36.25 Gy (7.

The Influence of Rice Husk Ash Incorporation on the Properties of Cement-Based Materials.

Rice husk ash is a kind of biomass material. Its main component is silicon dioxide, with a content of up to 80%. It has high pozzolanic activity and can react with hydroxide in cement.

The Effect of Relative Humidity on Creep Behavior of Cement Paste Microprism.

Despite decades of extensive studies, the mechanism of concrete creep remains a subject of debate, mainly due to the complex nature of cement microstructure. This complexity is further amplified by the interplay between water and the cement microstructure. The present study aimed to better understand the creep mechanism through creep tests on microprisms of cement paste at hygral equilibrium.

Enhanced Detection of Viable O157:H7 in Romaine Lettuce Wash Water Using On-Filter Propidium Monoazide-Quantitative PCR.

Accurate detection of viable O157:H7 in fresh produce wash water is critical for ensuring food safety and mitigating foodborne illnesses. This study evaluated an optimized on-filter propidium monoazide (PMA)-quantitative PCR (qPCR) method for detecting viable O157:H7 in romaine lettuce wash water, involving PMA pretreatment on a filter to block DNA amplification from dead cells. The method consistently detected viable cells across chemical oxygen demand (COD) levels of 1000 and 200 mg O/L, with no significant differences ( > 0.

Abdominal visceral and subcutaneous adipose tissue associations with postmenopausal breast cancer incidence.

Background: Obesity, classified by body mass index (BMI), is associated with higher postmenopausal breast cancer (BCa) risk. Yet, the associations between abdominal visceral (VAT) and subcutaneous adipose tissue (SAT) with BCa are unclear.

Methods: We assessed BCa associations with abdominal VAT and SAT in a prospective cohort of postmenopausal women without a history of cancer and with 27 years follow-up (N = 9950), during which all new cancers were adjudicated.