Active components unveiling and pharmacodynamic research on Valeriana jatamansi jones for ameliorating ulcerative colitis based on pharmacokinetics and network pharmacology.

Ethnopharmacological Relevance: Valeriana jatamansi Jones (V. jatamansi), a traditional Chinese medicine, is widely used in the treatment of gastrointestinal disorders, such as ulcerative colitis (UC). However, the active components of V.

[Parkin deletion affects PINK1/Parkin-mediated mitochondrial autophagy to exacerbate neuroinflammation and accelerate progression of Parkinson's disease in mice].

Objectives: To investigate the role of mitochondrial autophagy disorder caused by deletion of E3 ubiquitin ligase Parkin in neuroinflammation in a mouse model of MPTP-induced Parkinson's disease (PD).

Methods: Wild-type (WT) male C57BL/6 mice and Parkin mice were given intraperitoneal injections with MPTP or PBS for 5 consecutive days, and the changes in motor behaviors of the mice were observed using open field test. The effects of Parkin deletion on PD development and neuroinflammation were evaluated using immunofluorescence and Western blotting.

A multicenter retrospective study of the combination of immune checkpoint inhibitors and chemotherapy regimens with or without liver metastasis for the first-line treatment of advanced gastric cancer.

Background: Several studies have indicated that the use of immune checkpoint inhibitors (ICI) can prolong the survival of patients with advanced gastric cancer (AGC). However, it remains unclear whether the presence of liver metastasis leads to systemic immune suppression, resulting in poorer immune therapy outcomes. This study aims to investigate whether liver metastasis affects the efficacy of ICI in first-line treatment for AGC patients.

Synergistic effects of heterogeneous mature compost and aeration rate on humification and nitrogen fixing during kitchen waste composting.

Sludge mature compost (SMC) is notable for its high production, easy accessibility, and stable supply. This study investigated the impact of the SMC addition and different aeration rates on the humification and nitrogen fixing process during kitchen waste composting. The results demonstrated that addition of SMC prolonged the thermophilic phase, as a comparison, increased aeration shortened this phase.

Causal relationship between immune cells and periodontitis: A Mendelian randomization study.

This study employed Mendelian randomization (MR) analysis to explore potential causal relationships between 731 immune cell subtypes and periodontitis. Utilizing a 2-sample MR design, our study delved into the diverse landscape of immune cell interactions with periodontitis-associated factors. Multiple MR methods, including inverse variance weighting, weighted median, and MR-Egger tests, were employed to ensure reliability and mitigate potential pleiotropic effects.

In-depth exploration of microbial electrolysis cell coupled with anaerobic digestion (MEC-AD) for methanogenesis in treating protein wastewater at high organic loading rates.

High concentrations of protein wastewater often reduce treatment efficiency due to ammonia inhibition and acid accumulation caused by its low carbon-to-nitrogen ratio (C/N) after digestion, as well as its complex structure. This study investigates the performance of a microbial electrolysis cell (MEC) driving a protein digestion system with gradually increasing organic loading rates (OLR) of bovine serum albumin, elucidating microbial changes and methanogenic metabolic pathways on bioelectrodes under high OLR "inhibited steady-state" (ISS) conditions. The results showed that the accumulation of ammonia nitrogen (AN) from protein hydrolysis under high OLR conditions disrupted microbial growth and caused cell death on the electrode surface, hindering the electron transfer rate.

Integrated single-cell transcriptome and TCR profiles of hepatocellular carcinoma highlight the convergence on interferon signaling during immunotherapy.

Background: Despite the success of immune checkpoint inhibitor (ICI)-based combination therapies in hepatocellular carcinoma (HCC), its effectiveness remains confined to a subset of patients. The development of reliable, predictive markers is important for accurate patient stratification and further mechanistic understanding of therapy response.

Methods: We comprehensively analyzed paired single-cell RNA transcriptome and T-cell repertoire profiles from 14 HCC ascites samples, collected from 7 patients before and after treatment with the combination of sintilimab (anti-PD-1) and bevacizumab (anti-VEGF).

A comparison between single and fractionated doses of albumin-bound paclitaxel in the treatment of advanced esophageal cancer: A multicenter case-control study.

Purpose: At present, albumin-bound paclitaxel combined with platinum is the standard first-line treatment option for advanced esophageal cancer (EC). However, following a hospitalization surge, clinicians may prefer to use albumin-bound paclitaxel as a single dose. The present study aimed to investigate the survival of patients with advanced EC when treated with single or fractionated doses of albumin-bound paclitaxel.

Impact of cellulolytic nitrogen-fixing composite inoculants on humification pathways and nitrogen cycling in kitchen waste composting.

Low humification and nitrogen loss pose substantial challenges to the resource utilization in kitchen waste composting. This study investigated the effects of brown-rot fungi (BRF), cellulolytic nitrogen fixing bacteria (CNFB), and their composite microbial inoculants (CMI) during composting. Results indicated that microbial inoculants extended the thermophilic phase and enhanced cellulose degradation.

Non-destructive determination of ginsenosides in ginseng by combined hyperspectral and X-ray techniques based on ensemble learning.

The potential of hyperspectral imaging and X-ray techniques for the non-destructive determination of the ginsenosides Rg1 + Re and Rb1 in ginseng was investigated. The random forest (RF) models were established using spectral information extracted from hyperspectral data to predict ginsenosides content. The RF model was optimized by data pre-processing methods and feature screening methods.

Ferroptosis-related gene signature for predicting prognosis and identifying potential therapeutic drug in EGFR wild-type lung adenocarcinoma.

Epidermal growth factor receptor wild type lung adenocarcinoma (EGFR LUAD) still has limited treatment options and unsatisfactory clinical outcomes. Ferroptosis, as a form of cell death, has been reported to play a dual role in regulating tumor cell survival. In this study, we constructed a 3-ferroptosis-gene signature, FeSig, and verified its accuracy and efficacy in predicting EGFR LUAD prognosis at both the RNA and protein levels.

Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis BB-12 promote infected wound healing via regulation of the wound microenvironment.

Infected wounds can result in complex clinical complications and delayed healing, presenting a significant global public health challenge. This study explored the effects of topical application of two probiotics, Lactobacillus rhamnosus GG (LGG) and Bifidobacterium animalis subsp. lactis BB-12, on the microenvironment of infected wounds and their impact on wound healing.

Nanobubble-enabled foam fractionation to remove algogenic odorous micropollutants.

Due to climate change and environmental pollution, natural lakes and reservoir water suffer increasingly serious algal blooms and associated water quality problems due to the presence of algal or algogenic organic matter (AOM) such as algal odour and toxins. Effective removal of these micropollutants, especially in the event of algal blooms, is critical to aesthetic values of water bodies, drinking water security and human health. The study investigated the removal efficiency of two common odorous compounds, trans-1,10-dimethyl-trans-9-decalol (geosmin) and 2-Methylisoborneol (2-MIB), using foam fractionation enabled by air nanobubbles with addition of two common cationic and anionic surfactants, sodium dodecyl sulfate (SDS) and cetyltrimethylammonium bromide (CTAB), to enhance foaming ability and stability.

Design and development of a stand-off Raman brassboard (SDU-RRS) for the spectroscopic study of planetary materials.

Raman spectroscopy has emerged as a crucial mineral analysis technique in planetary surface exploration missions. Nonetheless, the inherently low Raman scattering efficiency of planetary silicate materials makes it challenging to extract enough Raman information. Theoretical and experimental studies of the remote Raman scattering properties of planetary materials are also urgent requirements for future lunar and planetary explorations.