Publications by authors named "ChangJun Teng"

Article Synopsis
  • The study investigates the connection between brain changes and gene activity in individuals with obsessive-compulsive disorder (OCD), a condition marked by unwanted thoughts and repetitive actions.
  • By combining data from the Allen Human Brain Atlas and neuroimaging resources, researchers found a relationship between cortical thickness and specific gene expressions in the brains of those with OCD.
  • The findings reveal a link between neural structure and gene expression, suggesting that certain proteins and genes play a crucial role in understanding the biological underpinnings of OCD.
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Article Synopsis
  • Neuroimaging studies reveal structural and functional brain disruptions in OCD patients, but their mechanisms are still unclear.
  • The research involved 45 OCD patients and 42 healthy controls, focusing on abnormalities in local degree centrality (DC) and dynamic functional connectivity (dFC) using resting-state fMRI.
  • Findings indicated reduced DC in brain regions like the thalamus and cuneus, correlated with illness severity, and decreased dFC variability, suggesting impaired connections in the visual and sensorimotor networks for those with OCD.
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Article Synopsis
  • - Enhancing psychosocial functioning is essential for lowering the risk of relapse in individuals who have recovered from depression, as found in a year-long study involving 182 participants who were assessed multiple times post-remission.
  • - The study revealed that improvements in psychosocial functioning can decrease relapse odds by 54.2%, with subjective depressive symptoms, social support, and positive coping being key factors influencing this functioning.
  • - Notably, while negative automatic thoughts were crucial initially, the overall impact of social support and coping strategies remained consistently important throughout the follow-up period, suggesting a complex relationship between these factors and recovery over time.
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Objective: The aim of this study was to analyze the chief complaints of psychological crisis hotlines during the coronavirus disease 2019 (COVID-19) pandemic in Jiangsu, China, and to summarize the psychological characteristics of the public during the different stages of COVID-19.

Methods: The chief complaints of calls to the psychological crisis hotline from 27 January 2020 to 30 June 2020. A total of 578 calls were extracted and grouped using thematic analysis into categories.

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The ultimate goal of depression treatment is to achieve functional recovery. Psychosocial functioning is the main component of functional impairment in depressed patients. The concept of psychosocial functioning has an early origin; however, its concept and connotation are still ambiguous, which is the basic and key problem faced by the relevant research and clinical application.

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Background: The importance of psychosocial functioning in the assessment, diagnosis and treatment of major depressive disorder (MDD) is widely recognised. However, there is a lack of effective scales to assess psychosocial functioning in patients with MDD.

Aims: To develop a professional questionnaire to evaluate the psychosocial functioning of patients with MDD.

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Background: Cognitive behavioral therapy (CBT) is an established treatment for Major Depressive Disorder (MDD). MDD is characterized by imbalanced communication patterns among three networks: the central executive network (CEN), the default mode network (DMN) and the salience network (SN). The effect of CBT in restoring communications among these networks in MDD is unknown.

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Background: Psychological resilience may reduce the impact of psychological distress to some extent. We aimed to investigate the mental health status of the public during the outbreak of coronavirus disease 2019 (COVID-19) and explore the level and related factors of anxiety and depression.

Methods: From February 8 to March 9, 2020, 3,180 public completed the Zung's Self-Rating Anxiety Scale (SAS) for anxiety, Zung's Self-Rating Depression Scale (SDS) for depression, the Connor-Davidson resilience scale (CD-RISC) for psychological resilience, and the Simplified Coping Style Questionnaire (SCSQ) for the attitudes and coping styles.

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Introduction: Dysfunctional connectivity of resting-state functional networks has been observed in patients with major depressive disorder (MDD), particularly in cognitive function networks including the central executive network (CEN), default mode network (DMN) and salience network (SN). Findings from studies examining how aberrant functional connectivity (FC) changed after antidepressant treatment, however, have been inconsistent. Thus, the purpose of the present study was to explore potential mechanisms of altered cognitive function networks during resting-state between remitted major depressive disorder (rMDD) patients and healthy controls (HCs) and furthermore, the relationship between dysfunctional connectivity patterns in rMDD and clinical symptoms.

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Panic disorder (PD) is associated with anticipatory anxiety, a sustained threat response that appears to be related to the bed nucleus of the stria terminalis (BNST). Individuals with panic disorder may demonstrate significant differences in causal connectivity of the BNST in comparison to healthy controls. To test this hypothesis, resting-state functional magnetic resonance imaging (fMRI) was used to identify aberrant causal connectivity of the BNST in PD patients.

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Background: Cognitive dysfunctions, such as impaired cognitive control, are frequently observed in patients with major depressive disorder (MDD). Although the cognitive control network (CCN) is widely considered a core feature of major depressive disorder (MDD), the relationship between cognitive dysfunction and symptom dimensions remains unclear. This study investigated differences in resting-state functional connectivity of the cognitive control network (CCN) between first-episode medication-naive MDD patients and remitted MDD.

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Background: Occupational burnout in physicians is prevalent and can have many negative effects. The purposes of this study were to explore the prevalence of occupational burnout and to analyze the effects of social support and role stress on occupational burnout among Chinese physicians.

Methods: Using multistage-stratified cluster random sampling, physicians were selected to participate in the study and completed three questionnaires: the Chinese Maslach Burnout Inventory; the Cross-Cultural Role Conflict, Ambiguity and Overload Scale; and the Social Support Rating Scale.

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Background: Major depressive disorder (MDD) is associated with abnormalities in brain structure. However, structural abnormality findings have been inconsistent and how structural changes lead to progressive morphometric alterations in depressed brain regions remains unclear.

Methods: High-resolution T1-weighted magnetic resonance images of first-episode medication-naïve MDD patients (20 men, 36 women) and healthy control participants (33 men, 23 women) were evaluated.

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Background: Women are more susceptible to major depressive disorder (MDD). A possible explanation is that women have a trait tendency to engage in a ruminative response style. Depending on cognitive model of depression, attention bias, memory bias and self-referential bias were closely related among depressed patients.

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