Publications by authors named "Chang-zhen Shang"
Article Synopsis
- The study investigates the prevalence and mortality outcomes of metabolic dysfunction-associated fatty liver disease (MAFLD) in the USA over 30 years, highlighting the need to address the rising obesity and diabetes epidemic.
- It analyzed data from 72,224 participants across various health surveys, categorizing MAFLD into seven subtypes based on diagnostic criteria and risk factors.
- Results show a significant increase in MAFLD prevalence from 22% in 1988-1994 to 36% in 2017-2020, with an increased mortality risk, particularly for metabolically unhealthy individuals with normal weight.
Article Synopsis
- The study explores the association between vitamin C (VC) levels and metabolic dysfunction-associated fatty liver disease (MAFLD), highlighting the need for effective treatments amid ongoing challenges in managing the condition.
- Analysis of data from the National Health and Nutrition Examination Survey 2017-2018 indicates that individuals with higher serum VC levels were predominantly female, more educated, and moderate drinkers, showing a possible connection to lower prevalence rates of liver diseases.
- The findings suggest that women generally have a lower risk of fatty liver diseases, and specifically, individuals in the higher quartiles of VC status exhibited a decreased likelihood of MAFLD compared to NAFLD, indicating the potential protective role of vitamin C.
Cholecystectomy is the "gold standard" for treating diseases of the gallbladder. In addition, non-alcoholic fatty liver disease (NAFLD), liver fibrosis or cirrhosis, are major causes of morbidity and mortality across the world. However, the association between cholecystectomy and these diseases is still unclear.
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- The study presents a novel laparoscopic approach for segment 7 (S7) liver resections that avoids traditional methods' complications by utilizing an in situ split technique, which streamlines the process and adheres to "no-touch" principles for tumors.
- From September 2017 to May 2019, 24 patients underwent this procedure with successful outcomes, showing that it is technically feasible and effective in achieving R0 resections of primary liver cancer.
- The results indicated good operational success, including no perioperative deaths, average surgery time of about 216.5 minutes, and manageable blood loss, demonstrating that this approach provides better visibility and maneuverability.
Background: Duodenum-preserving total pancreatic head resection (DPPHRt) is an accepted alternative surgical procedure for benign or low-grade malignant tumors of the pancreatic head by preserving the duodenum with its intact blood supply from the pancreatic duodenal arterial arcade. This study describes our experience in laparoscopic DPPHRt (LDPPHRt). To our knowledge, this is the first description of this novel minimally invasive operation.
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- Acetaminophen overdose is a leading cause of drug-induced liver failure, causing oxidative stress and cell damage.
- Omega-3 polyunsaturated fatty acids (n-3 PUFA) show promise in reducing liver injury, but their specific effects on acetaminophen hepatotoxicity were previously unclear.
- In a study, fat-1 transgenic mice, which produce n-3 PUFA, displayed significantly less liver damage compared to wild type mice after APAP injection, indicating that n-3 PUFA may offer protective benefits against acetaminophen-induced liver injury.
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death worldwide. In the present study, we aimed to profile the possible changes in plasma phospholipid fatty acid composition of HCC patients, and to identify the fatty acid biomarkers that could distinguish HCC patients from healthy controls. A total of 37 plasma samples from healthy controls and HCC patients were collected and their phospholipid fatty acid profiles were characterized by gas chromatography-mass spectrometry followed by multivariate statistical analysis.
View Article and Find Full Text PDFUnlabelled: The deregulation of microRNAs (miRNAs) plays an important role in human hepatocarcinogenesis. In this study, we highlight exosomes as mediators involved in modulating miRNA profiles in hepatocellular carcinoma (HCC) cells. First, we examined the different miRNA expression profiles in HCC cells and HCC cell-derived exosomes.
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- Cabozantinib is a multitargeted tyrosine kinase inhibitor currently undergoing phase III trials for hepatocellular carcinoma (HCC), focusing on reversing drug resistance caused by P-glycoprotein (P-gp).
- The study found that cabozantinib increased the effectiveness of P-gp substrate drugs without affecting non-P-gp substrates or altering the expression levels of P-gp itself; instead, it enhanced the activity of P-gp ATPase.
- Ultimately, cabozantinib may aid in overcoming multidrug resistance in HCC and improving chemotherapy outcomes by directly inhibiting P-gp's function.
Background: The best preoperative examination in Graves' disease with thyroid cancer still remains uncertain. The objectives of the present study were to investigate the prevalence of thyroid cancer in Graves' disease patients, and to identify the predictive factors and ultrasonographic features of thyroid cancer that may aid the preoperative diagnosis in Graves' disease.
Methods: This retrospective study included 423 patients with Graves' disease who underwent surgical treatment from 2002 to 2012 at our institution.
Objective: To investigate the roles of E-cadherin (E-cad) in enhancing the in vitro differentiation of hepatocytes from murine embryonic stem cells (ESCs).
Methods: Exogenous E-cad was transfected into BALB/c murine ESCs to enable its stable expression. Then hepatic differentiation from E-cad-ESCs was induced by such growth factors as hepatocyte growth factor (HGF), fibroblast growth factor (FGF) and transforming growth factor (TGF).
Failure of immune surveillance related to inadequate host antitumor immune responses has been suggested as a possible cause of the high incidence of recurrence and poor overall survival outcome of hepatocellular carcinoma. The stress-induced heat shock proteins (HSPs) are known to act as endogenous "danger signals" that can improve tumor immunogenicity and induce natural killer (NK) cell responses. Exosome is a novel secretory pathway for HSPs.
View Article and Find Full Text PDFAim: To establish an efficient culture system to support embryonic stem (ES) cell differentiation into hepatocytes that coexpress F-VIII and F-IX.
Methods: Mouse E14 ES cells were cultured in differentiation medium containing sodium butyrate (SB), basic fibroblast growth factor (bFGF), and/or bone morphogenetic protein 4 (BMP4) to induce the differentiation of endoderm cells and hepatic progenitor cells. Hepatocyte growth factor, oncostatin M, and dexamethasone were then used to induce the maturation of ES cell-derived hepatocytes.
Aim: To summarize the clinical experience of laparoscopic hepatectomy at a single center.
Methods: Between November 2003 and March 2009, 78 patients with hepatocellular carcinoma (n = 39), metastatic liver carcinoma (n = 10), and benign liver neoplasms (n = 29) underwent laparoscopic hepatectomy in our unit. A retrospective analysis was done on the clinical outcomes of the 78 patients.
Recently significant progress has been made in differentiating embryonic stem (ES) cells toward pancreatic cells. However, little is known about the generation and identification of pancreatic progenitor cells from ES cells. Here we explored the influence of sodium butyrate on pancreatic progenitor differentiation, and investigated the different effects of sodium butyrate on pancreatic and hepatic progenitor formation.
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- The study explored whether embryonic stem (ES) cells can differentiate into exocrine pancreatic cells, building on existing knowledge of their potential for endocrine differentiation.
- Sodium butyrate, glucocorticoids (specifically dexamethasone), and activinA were used to enhance this differentiation, with various experiments conducted to assess their effects.
- The findings indicated that a combination of these agents significantly increased the expression of exocrine pancreatic markers in ES cells, suggesting a potential method for researching pancreatic development and diseases.
Article Synopsis
- A study was conducted to evaluate the effectiveness of splenic autotransplantation combined with lower esophagus transaction anastomosis in treating portal hypertension due to liver cirrhosis.
- Thirty-six patients were randomly assigned to either the splenic autotransplantation group or a control group that only underwent splenectomy, and various health markers were monitored before and after the procedures.
- Results showed that patients in the splenic autotransplantation group had significantly higher levels of immune markers compared to the control group two months post-surgery, indicating it may help preserve immune function.
[MicroRNA differential expression profile during differentiation of embryonic stem cells towards hepatocytes induced by sodium butyrate].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
August 2008
Objective: To explore the expression profile of microRNAs during the course of embryonic stem cells differentiation towards hepatocytes induced by sodium butyrate.
Methods: Total RNA was extracted from embryonic stem cells on day 0, 6, and 9 during cell differentiation, and microRNA was isolated from the total RNA. Microarray analysis of microRNA expression was performed to detect the different expression levels of microRNA among the indicated time points (day 0, 6, and 9).
Aim: There is increasing evidence indicating that embryonic stem (ES) cells are capable of differentiating into hepatocyte-like cells in vitro. However, it is necessary to improve the differentiation efficiency so as to promote the clinical application. Here, we report an efficient culture system to support hepatocyte differentiation from ES cells by utilizing cholestatic serum.
View Article and Find Full Text PDF[Diagnosis and treatment of primary tumor of small intestine: a report of 58 cases].
Zhonghua Wei Chang Wai Ke Za Zhi
July 2007
Objective: To summarize the pathological classification, clinical symptom and experience in the diagnosis and treatment of primary tumor of small intestine.
Methods: Data of 58 patients with primary tumor of small intestine pathologically confirmed from Oct. 1996 to Oct.