GSDMD/Drp1 signaling pathway mediates hippocampal synaptic damage and neural oscillation abnormalities in a mouse model of sepsis-associated encephalopathy.

Background: Gasdermin D (GSDMD)-mediated pyroptotic cell death is implicated in the pathogenesis of cognitive deficits in sepsis-associated encephalopathy (SAE), yet the underlying mechanisms remain largely unclear. Dynamin-related protein 1 (Drp1) facilitates mitochondrial fission and ensures quality control to maintain cellular homeostasis during infection. This study aimed to investigate the potential role of the GSDMD/Drp1 signaling pathway in cognitive impairments in a mouse model of SAE.

Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes.

In this study, targeted sequencing to screen 50 multidrug refractory multiple myeloma (rMM) patients was performed by using the Multiple Myeloma Mutation Panel. Patients were pretreated with both immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs), and 88%, 78%, and 68% were refractory to an IMiD, a PI, or both, respectively. The majority of patients had progressive (82%) or refractory (78%) disease immediately before sampling, with 43% being IMiD refractory and 46% being PI refractory in the most recent line of therapy.

Ifenprodil induced antinociception and decreased the expression of NR2B subunits in the dorsal horn after chronic dorsal root ganglia compression in rats.

Background: Spinal N-methyl D-aspartate receptors play an important role in the pathogenesis of neuropathic pain, and administration of N-methyl D-aspartate receptor antagonists can attenuate this hyperpathia. Ifenprodil is an antagonist selective for N-methyl D-aspartate receptor 2B (NR2B) subunits. Several researches have reported effective analgesia of ifenprodil in animal models of neuropathic pain.

Clinical evaluation of 546 tetracycline-stained teeth treated with porcelain laminate veneers.

Objective: The purpose of this study was to evaluate the clinical result of 546 tetracycline-stained teeth restored with a porcelain laminate veneer system (Cerinate, Den-Mat, USA) for aesthetic reasons.

Methods: Tetracycline-stained teeth (546) were restored with a porcelain veneer system, and bonded with Ultra Bond resin cement. The restorations were recalled after 0.

[Comparison of fracture resistance of pulpless teeth restored with fiber reinforced composite posts and three kinds of resin core material].

Objective: To compare the fracture resistances of pulpless teeth restored with FRC (Fiber Reinforced Composite) posts and three kinds of resin core material.

Methods: A total of 42 recently extracted upper incisors were randomly divided into 3 groups. Group A was restored with prefabricated glass-fiber posts and Artglass polymer core; group B with prefabricated glass-fiber posts and Charisma composite resin core; and group C with prefabricated glass-fiber posts and AB composite resin core.

[Bonding strength and interface effects of different dentin surface on acetone-based adhesives bonding].

Purpose: To study the influences on microstructure characteristic and bonding strength of acetone-based wet bonding systems when bonding on dry or wet dentin surface.

Methods: Three acetone-based wet bonding systems, Gluma One-Bond, Bond-1 and One-Step, were used to bond Chrisma composite resin to dry or moist dentin surface, and the bonding interface was observed with HITACHI S-2700 scanning electron microscope. Microtensile strengths of different groups were measured with Instro 1195.

[Study on the infinity optical thickness of light-cured composite resins and attached shade guides].

Objective: This study compared the opaque characteristics of light-cured composite resins and attached shade guides.

Methods: Three kinds of light-cured composite resins and attached shads guides were used. A plastic mold (10mm in diameter and 4mm in height) was used to prepare disk specimens.

[Analysis of infinity optical thickness between nine kinds of composite resins with the same color mark].

Objective: This study compared the infinity optical thickness of composite resins with the same color marks.

Methods: In this test nine composite resins (shade A2) were used. A plastic mold (10mm in diameter, 4mm in height) was used to prepare 27 disk specimens.

[Clinical evaluation of 546 tetracycline-stained teeth treated with Cerinate laminate veneers].

Objective: The purpose of this study was to evaluate the clinical result of 546 tetracycline-stained teeth corrected with Cerinate porcelain laminate veneer system for esthetic purpose.

Methods: 546 tetracycline-stained teeth were corrected with Cerinate porcelain veneer system, and bonded with Ultra Bond resin cement. The restorations were recalled after 0.

[Scanning electron microscope observation of the effect of different dentin bonding surfaces on the bonding interface].

To study the microstructural influence of dry or wet dentin bonding surface on the dentin bonding interface, five wet bonding systems were used to bond Chrisma B20 resin with dry or moist dentin surface with scanning electron microscope. All these systems were found to be well able to infiltrate into the dentin bonding interface on wet dentin surface, and significant changes occurred in the bonding interface when acetone-based adhesives were applied on dry dentin surfaces, demonstrating thinner hybrid layer and the formation of partially hybrid region, while alcohol- and water-based adhesives showed no changes. The necessity of moist dentin surface is therefore suggested when wet bonding systems are used.