Objective: To evaluate the feasibility of the injectable thermosetting chitosan-glycerophosphate-fibroblast (C-GP-FB) hydrogel as an embolizing material of intracranial aneurysm.
Methods: 2% chitosan solution and 56% glycerophosphate solution were mixed in different volume ratio to detect the pH, colloidization time at 37 degrees C, and mechanic strength. Fibroblasts were isolated from the skin of a rabbit and cultured with C-GP hydrogel of different ratios so as to determine the best ratio.