Growth arrest-specific 6 protein in HIV-infected patients: Determination of plasma level and different antiretroviral regimens.

Background/purpose: Growth arrest-specific 6 (Gas6) protein is involved in cell proliferation, differentiation, adhesion, migration in response to inflammatory processes. Human immunodeficiency virus (HIV) infection induces a chronic inflammatory condition and combination of antiretroviral therapy improves immune function and decreases the inflammatory state. The aim of this study was to assess the implications of Gas6 in chronic inflammation status of HIV-infected patients undergoing different third regimens of antiretroviral therapy.

Monitoring early developed low bone mineral density in HIV-infected patients by intact parathyroid hormone and circulating fibroblast growth factor 23.

Background/purpose: HIV-infected patients have a high prevalence of low bone mineral density (BMD), but BMD changes remain unclear. This cross-sectional retrospective observational study aimed to characterize the prevalence and associated factors of low BMD in HIV patients.

Methods: Between 1 January 2015 and 31 December 2016, all patients aged 20 years or greater who sought for HIV care were included.

Syntheses, structural characterisation and electronic structures of ferrocenyl-osmafuran heterobinuclear organometallic complexes.

The heterobinuclear complex OsCl(PPh)[CHC(PPh)CFcO] (Fc = (CH)Fe(CH)) (1) in which the two metal centers were connected by the skeleton of the osmafuran and cyclopentadienyl was synthesized via a one-pot reaction of OsCl(PPh) and FcCOC[triple bond, length as m-dash]CH in high yield. Three derivatives (Os(η-OCOO)(PPh)[CHC(PPh)CFcO] (2), Os(NCS)(PPh)[CHC(PPh)CFcO] (3), and OsCl(dppb)[CHC(PPh)CFcO] (dppb = PhP(CH)PPh) (4)) were obtained by the ligand substitution reactions of complex 1 with different reagents (CsCO (2), NaSCN (3) and dppb (4)), respectively. All of these complexes were characterized by NMR spectroscopy and elemental analysis and the structures of complexes 1, 3 and 4 were further confirmed by single crystal X-ray diffraction.

Phylogenetic and recombination analysis of rice black-streaked dwarf virus segment 9 in China.

Rice black-streaked dwarf virus (RBSDV) is an economically important virus that causes maize rough dwarf disease and rice black-streaked dwarf disease in East Asia. To study RBSDV variation and recombination, we examined the segment 9 (S9) sequences of 49 RBSDV isolates from maize and rice in China. Three S9 recombinants were detected in Baoding, Jinan, and Jining, China.

The co-existence of two growth hormone receptors and their differential expression profiles between female and male tongue sole (Cynoglossus semilaevis).

Growth hormone receptor (Ghr) is a single-transmembrane pass protein which is important in initiating the ability of growth hormone (Gh) to regulate development and somatic growth in vertebrates. In this study, molecular cloning, expression analysis of two different ghr genes (ghr1 and ghr2) in the tongue sole (Cynoglossus semilaevis) was conducted. As a result, the ghr1 and ghr2 cDNA sequences are 2364 bp and 3125 bp, each of which encodes a transmembrane protein of 633 and 561 amino acids (aa), respectively.

[Cu2+ and Zn2+-induced aggregation of amyloid-beta peptide].

To study the effect of Cu2+ and Zn2+ on amyloid-beta peptides (Abeta) aggregation, the morphology, size and cell toxicity of Abeta40 aggregates formed with the metal ions have been observed by the methods including ultraviolet spectroscopy, fluorescence spectroscopy and transmission electron microscopy. The results showed that Cu2+ and Zn2+ can accelerate Abeta40 aggregation, and both changed the morphology and size of Abeta40 aggregates. Zn2+ induced Abeta40 to form fibrous Abeta40 aggregates, while the amorphous and fibrous aggregates were produced by the interaction between Cu2+ and Abeta40.

Genomic structure, polymorphism and expression analysis of the growth hormone (GH) gene in female and male Half-smooth tongue sole (Cynoglossus semilaevis).

Growth hormone (GH) is a polypeptide which is an important regulator of development and somatic growth in teleosts, and may be associated with the mechanisms which drive sexual growth dimorphism in the Half-smooth tongue sole (Cynoglossus semilaevis). In this study, the full length gh cDNA was cloned from C. semilaevis by homology cloning and the rapid amplification of cDNA ends polymerase chain reaction (RACE-PCR).

Molecular cloning, expression analysis of insulin-like growth factor I (IGF-I) gene and IGF-I serum concentration in female and male Tongue sole (Cynoglossus semilaevis).

Insulin-like growth factor I (IGF-I) is a polypeptide hormone that regulates growth during all stages of development in vertebrates. To examine the mechanisms of the sexual growth dimorphism in the Tongue sole (Cynoglossus semilaevis), molecular cloning, expression analysis of IGF-I gene and IGF-I serum concentration analysis were performed. As a result, the IGF-I cDNA sequence is 911 bp, which contains an open reading frame (ORF) of 564 bp encoding a protein of 187 amino acids.

The chelation targeting metal-Aβ40 aggregates may lead to formation of Aβ40 oligomers.

The fluorescent chelator (FC-1) was designed by combining a metal-chelating unit and a ThT-based Aβ aggregate-binding fluorescent unit. FC-1 is a cell membrane-penetrable chelator with a moderate chelation ability to Cu(2+) and Zn(2+) and can target metal-Aβ40 aggregates. Treatment with FC-1 led to enhanced cytotoxicity of the aggregates, because the aggregates were converted into a pool of oligomers.

9-{4-[(E)-2-(4,6-Dimethyl-1,3,5-triazin-2-yl)ethen-yl]phen-yl}-9H-carbazole.

In the crystal structure of the title compound, C(25)H(20)N(4), the triazinyl ring is nearly coplanar with the planar (r.m.s.

[Percutaneous vertebroplasty for the treatment of acute burst thoracolumbar fractures].

Objective: To explore the feasibility of percutaneous vertebroplasty for the treatment of acute burst thoracolumbar fracture.

Methods: Fifty-eight patients (male 38 and female 20, ranging in age from 38 to 70 years, with an average of 56.8 years) with acute burst thoracolumbar fracture were treated by percutaneous vertebroplasty.

Three-dimensional networks in 5-methylimidazolium 3-carboxy-4-hydroxybenzenesulfonate and bis(5-methylimidazolium) 3-carboxylato-4-hydroxybenzenesulfonate.

The two title proton-transfer compounds, 5-methylimidazolium 3-carboxy-4-hydroxybenzenesulfonate, C(4)H(7)N(2)(+).C(7)H(5)O(6)S(-), (I), and bis(5-methylimidazolium) 3-carboxylato-4-hydroxybenzenesulfonate, 2C(4)H(7)N(2)(+).C(7)H(5)O(6)S(2-), (II), are each organized into a three-dimensional network by a combination of X-H.

Two salts of 5-sulfosalicylic acid and 3-aminopyridine.

5-Sulfosalicylic acid (5-SSA) and 3-aminopyridine (3-APy) crystallize in the same solvent system, resulting in two kinds of 1:1 proton-transfer organic adduct, namely 3-aminopyridinium 3-carboxy-4-hydroxybenzenesulfonate monohydrate, C(5)H(7)N(2)(+).C(7)H(5)O(6)S(-).H(2)O or 3-APy.

[Evaluation of antibacterial activity of amoxycillin sodium and clavulanate potassium and the pharmacoeconomics in the therapy of acute respiratory infection].

Objective: To explore the antibacterial activity of amoxycillin sodium and clavulanate potassium (trade name: Anqi) in vitro and the pharmacoeconomics in the therapy of acute respiratory infection.

Methods: Minimal inhibition concentration (MIC), minimal bactericidal concentration (MBC) and bactericidal curve of amoxycillin sodium and clavulanate potassium against common pathogens were determined and compared with some other same kind of antibiotics without beta-Lactamase inhibitor. Eighty cases diagnosed as respiratory infection were randomly divided into 4 groups: group 1 was treated with i.