Di-(2-ethylhexyl) phthalate exacerbates abnormalities of testicular development in F1 males via inhibition the Wnt/β-catenin signaling pathway.

The theory of "Developmental Origins of Health and Disease (DOHaD)" espouses that environmental exposures to toxicants during critical developmental stages can affect health outcomes in adulthood. Di (2-ethylhexyl) phthalate (DEHP) is a plasticizer that can be transferred to developing organisms via the placenta and breast milk as an environmental endocrine disruptor. We herein implemented a cross-fostering model to decipher the contributions of prenatal vs.

Retinoic acid downregulates microRNAs to induce abnormal development of spinal cord in spina bifida rat model.

Objects: MicroRNAs have been found in the developing central nervous system, but little is known about their functions in development, especially in the abnormal development of spinal cord in spina bifida. To this end, we have studied the mechanism of microRNAs involved in the morphogenesis of the spinal cord in all-trans-retinoic acid (RA)-treated spina bifida rat fetus.

Materials And Methods: Timed-pregnant rats were gavage-fed RA, and embryos were obtained on 13.

[Effects of perioperative music on sedation in patients undergoing gynecological surgery under intravertebral anesthesia].

Objective: To investigate the effects of music on propofol target-controlled infusion (TCI) in patients during gynecological surgery under intravertebral anesthesia.

Methods: One hundred and ten patients scheduled for gynecological surgery under intravertebral anesthesia were randomly assigned to two groups. The music group patients were asked to determine music and its sound volume preoperatively, which were played from 6 min before the surgery to the end.