[Effect of Electroacupuncture of "Weizhong" (BL 40) and "Huantiao" (GB 30) on cAMP-PKA-CREB Signaling of Spinal Cord in Rats with Neuropathic Pain].

Objective: We have demonstrated that electroacupuncture (EA) of "Weizhong" (BL 40) and "Huantiao" (GB 30) could evidently relieve mechanical hyperalgesia in spared nerve injury (SNI) rats. The present study was designed to observe the effect of EA on levels of cAMP, and protein kinase A (PKA) and cAMP response element binding protein (CREB) in the lumbar spinal cord of the same pain model rats, so as to explore its mechanisms underlying improvement of neuropathic pain.

Methods: One hundred male SD rats were randomly divided into 5 groups: sham operation, model, EA, AP-5 and L-NAME groups (＝20 in each group).