Causal impact of human blood metabolites and metabolic pathways on serum uric acid and gout: a mendelian randomization study.

Objective: Hyperuricaemia and gout are common metabolic disorders. However, the causal relationships between blood metabolites and serum urate levels, as well as gout, remain unclear. A systematic evaluation of the causal connections between blood metabolites, hyperuricemia, and gout could enhance early screening and prevention of hyperuricemia and gout in clinical settings, providing novel insights and approaches for clinical treatment.

No evidence of a causal relationship between ankylosing spondylitis and cardiovascular disease: a two-sample Mendelian randomization study.

Objective: Observational studies have suggested an increased risk of cardiovascular disease in individuals with ankylosing spondylitis. However, these studies are prone to confounding factors and reverse causality. To address these limitations, we conducted a Mendelian randomization study to assess the causal relationship between AS and CVD.

Morphological and phylogenetic analyses reveal two new species in s.s. (Conidiobolaceae, Entomophthorales) from China.

The genus s.s. (Conidiobolaceae, Entomophthorales) has been delimited to accommodate members that produce microspores.

[Preparation of Sulfonated Graphene Oxide Modified Composite Nanofiltration Membrane and Application in Salts Separation].

In recent years, water resources are in short supply and seriously polluted. Increasingly more attention has been paid to the process of salt separation. The surface of the nanofiltration (NF) membrane is usually charged and can selectively allow the permeation of different ions.

Shielding membrane surface carboxyl groups by covalent-binding graphene oxide to improve anti-fouling property and the simultaneous promotion of flux.

Graphene oxide (GO) is an excellent material for membrane surface modification. However, little is known about how and to what extent surface functional groups change after GO modification influence membrane anti-fouling properties. Carboxyl is an inherent functional group on polyamide or other similar membranes.

Hepatoprotective effects of Solanum nigrum against ethanol-induced injury in primary hepatocytes and mice with analysis of glutathione S-transferase A1.

Background: Solanum nigrum is a herbaceous perennial plant, which is widely used in traditional medicine systems for its antioxidant, antiulcerogenic, antitumorigenic, and anti-inflammatory characteristics. The purpose of this study was to investigate the protective effects of S. nigrum against alcoholic liver damage in primary hepatocytes and mice, using glutathione S-transferase alpha 1 (GSTA1) as an indicator.