Enhancing Human Cutaneous Wound Healing through Targeted Suppression of Large Conductance Ca-Activated K Channels.

The modulation of K channels plays a crucial role in cell migration and proliferation, but the effect of K channels on human cutaneous wound healing (CWH) remains underexplored. This study aimed to determine the necessity of modulating K channel activity and expression for human CWH. The use of 25 mM KCl as a K channel blocker markedly improved wound healing in vitro (in keratinocytes and fibroblasts) and in vivo (in rat and porcine models).