Publications by authors named "Chang-Quan H"
Article Synopsis
- The study examined the association between the ARNTL2 (BMAL2) gene polymorphism rs2306074 T/C and the risk of developing Alzheimer’s disease (AD) in a Chinese population.
- Researchers analyzed data from 296 AD patients and 423 control subjects, finding that C carriers had a higher prevalence in AD patients compared to controls, particularly in those who do not carry the APOE ε 4 allele.
- Results indicated that while C carriers and those with CC genotypes show increased susceptibility to AD among APOE ε 4 non-carriers, this association does not hold for APOE ε 4 carriers.
Objective: Cigarette smoking has been confirmed as a factor influencing arterial blood pressure. In the present study, we studied whether cigarette smoking habits were still associated with arterial blood pressure among Chinese nonagenarians/centenarians.
Methods: The present study analyzed data from a survey conducted on all residents aged 90 years or more in the DuJiangYan district (in total 2,311,709 inhabitants) in 2005.
Objectives: In the present study, it was examined whether polymorphism of circadian locomotor output cycle kaput (CLOCK) gene 3111T/C was associated with susceptibility of Alzheimer disease (AD).
Methods: This study was conducted using a case-control method. Genotypes of apolipoprotein E (APOE e4) and CLOCK gene 3111T/C were determined by restriction fragment length polymorphism method and TaqMan assay method, respectively.
In this study, we examined the association of fasting serum insulin (FSI) and fasting serum glucose (FSG) with cognitive impairment in the very elderly using a sample of Chinese nonagenarians/centenarians. This study used data from a survey that was conducted in 2005 on all residents aged 90 years or more in a district with 2,311,709 inhabitants. FSG, FSI, and cognitive function were analyzed.
View Article and Find Full Text PDFObjective: We observed the function of hypothalamic-pituitary-thyroid axis in patients with Alzheimer disease (AD) using a case-control study.
Methods: The case was a cohort that included 50 patients with AD. For each case subject, 1 control who was of similar age, sex, daily activities (scale of Lawton), sleep quality (Pittsburgh Sleep Quality Index), and depression (15-item Geriatrics Depression Scale) was recruited.
Article Synopsis
- - This study analyzed the circadian rhythm of arterial blood pressure in non-hypertensive patients with Alzheimer's disease compared to normotensive controls, using a 24-hour monitoring method.
- - Researchers identified distinct dipper patterns of blood pressure among AD patients, revealing significant differences in nighttime blood pressure fluctuations compared to the controls.
- - Findings indicate that Alzheimer’s patients experience higher overall blood pressure and mean systolic blood pressure during the night, suggesting altered circadian regulation in these individuals.
Article Synopsis
- The study aimed to investigate the effects of cigarette smoking on serum lipid levels among Chinese individuals aged 90 and older, an age group that hasn't been extensively studied before.
- It analyzed data from a survey of over 2.3 million residents, focusing on 216 men and 445 women, using statistical methods to assess relationships between smoking and lipid levels.
- Results revealed that current smokers had lower total cholesterol levels and prevalence of hypercholesterolemia compared to nonsmokers, indicating that smoking may not increase the risk of dyslipidemia in this elderly population, contrary to findings in younger groups.
Purpose: The authors examined the individual association between sleep quality and cognitive function among the very elderly.
Methods: The present study analyzed data from a survey that was conducted on all residents aged 90 years or older in a district; there were 2,311,709 inhabitants in 2005. Cognitive function and sleep quality were measured using the 30-item Mini-Mental State Examination and the Pittsburgh Sleep Quality Index, respectively.
Objective: The goal of this study was to determine the relationship between living arrangements and risk for depression among older people.
Method: MEDLINE, EMBASE, The Cochrane Library database was used to identify potential studies. The studies were divided into cross-sectional and longitudinal subsets.
Article Synopsis
- - This study investigated the relationship between sleep quality and arterial blood pressure specifically in individuals aged 90 and older, as this link was uncertain in this age group.
- - Data from 216 men and 444 women revealed that there were no significant differences in sleep quality or blood pressure measures between those with and without hypertension.
- - The results concluded that, contrary to some expectations, sleep quality does not appear to affect arterial blood pressure in very elderly individuals.
The association of antihypertensive medication use with cognitive decline (including mild cognitive impairment) or dementia (including Alzheimer's disease (AD), vascular dementia (VD) and any dementia) has still been an area of controversy. This study examined the association of antihypertensive medication use with cognitive decline or dementia using a quantitative meta-analysis of longitudinal studies. EMBASE and MEDLINE were searched for articles published up to Feb 2011.
View Article and Find Full Text PDFBackground And Aims: In previous studies, the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma 2 (PPAR-γ2) was shown to be associated with both lipid metabolism and longevity. We examined whether the polymorphism continued to be associated with abnormal levels of serum lipid/lipoprotein among elderly subjects (≥90 years).
Methods: The Pro12Ala variant was examined using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).
We examined the individual association between body mass index (BMI) and sleep quality among the very elderly. The present study analyzed data from survey that was conducted on all residents aged 90 years or more in a district, there were 2,311,709 inhabitants in 2005. Subjects were divided into four groups according to quartile of BMI (<16.
View Article and Find Full Text PDFObjective: In the present study, we detected a relationship between serum lipid/lipoprotein [serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL)-cholesterol and high-density lipoprotein (HDL)-cholesterol] and arterial blood pressure among Chinese nonagenarians/centenarian.
Methods: The present study analyzed data from the survey that was conducted on all residents aged 90 years or more in a district; there were 2,311,709 inhabitants in 2005. Arterial blood pressure included systolic blood pressure (SBP) and diastolic blood pressure (DBP).
Article Synopsis
- This study investigates the link between education levels and the risk of depression in older adults, aiming to clarify whether less education increases depressive symptoms in late life.
- The research analyzed data from 24 cross-sectional and 12 longitudinal studies, which included over 50,000 participants, and revealed that individuals with less education faced a significantly higher risk of depression.
- The findings suggest that lower educational attainment is correlated with a heightened risk of late life depression, despite some limitations in the study’s methodology.
Depression and hypertension among Chinese nonagenarians and centenarians.
Int J Geriatr Psychiatry
June 2010
Purpose: In this study, we explored association between hypertension and depression in the very elderly using a sample ranged in age from 90 to 108 years.
Methods: A cross-sectional study.
Results: The sample included 687 unrelated Chinese nonagenarians/centenarians (67.
Objective: the goal of this study was to determine the relationship between health status, including self-rated health status and chronic disease, and risk for depression among the elderly.
Method: MEDLINE, EMBASE and The Cochrane Library Database were used to identify potential studies. The studies were classified into cross-sectional and longitudinal subsets.
Background And Aims: The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARgamma) has been associated with decreased obesity, insulin resistance, type 2 diabetes and other age-associated diseases such as cognitive impairment, hypertension, cancer, osteoarthritis. Each one of these diseases had been linked to depression. Moreover, there is also an association between Pro12 Ala polymorphism in PPAR gamma2 and longevity.
View Article and Find Full Text PDFObjective: To determine the effective components and the feasibility of collaborative care interventions (CCIs) in the treatment of depression in older patients.
Methods: Systematic review of randomized controlled trials, in which CCIs were used to manage depression in patients aged 60 or older.
Results: We identified 3 randomized controlled trials involving 3930 participants, 2757 of whom received CCIs and the others received usual care.
This study aimed to explore the relationship between insufficient renal 1-alpha hydroxylase (IRH) and bone homeostasis in type 2 diabetes mellitus (T2DM) or insulin resistance (IR) and to investigate whether IR plays a major role in the pathogenesis of both IRH and bone loss in T2DM. The experimental animal models of T2DM, IR, IR treated with vitamin D (VD), IR treated with 1-alpha hydroxyvitamin D (1alpha(OH) D, the product of renal 1-alpha hydroxylase), T2DM treated with VD, and T2DM treated with 1alpha(OH) D were established on 18-month-old male Wistar rats. For rats in each animal model and normal control rats, IR was detected by euglycemic insulin clamp technique (EICT) and glucose infusion rate (GIR, an index of IR) was calculated.
View Article and Find Full Text PDFObjective: The study aimed to explore the relationship among renal injury, abnormal vitamin D metabolism, and bone homeostasis in insulin resistance (IR) or type 2 diabetes mellitus (T2DM).
Design And Methods: The animal models of IR, T2DM, and T2DM treated with 1-alpha hydroxyvitamin D (1-alphaOHD) were established on 18-month-old male Wistar rats. Glucose infusion rates (GIR) and levels of urinary albumin (UA), serum 25-hydroxyvitamin D (25-(OH)D), serum 1,25-dihydroxyvitamin D (1,25-OH2D), and bone mineral density (BMD) in lumbar vertebrae and femoral bone were measured.