Publications by authors named "Chang-Qing Ma"
Effects of Occupational Exposure to Waste Anesthetic Gas on Oxidative Stress and DNA Damage.
Oxid Med Cell Longev
September 2021
Objective: The aim of the study was to investigate the potential effects of waste anesthetic gas (WAG) on oxidative stress, DNA damage, and vital organs.
Methods: A total of 150 members of the staff at a hospital were assigned to an exposure group or control group. The 68 operating room (OR) staff in the exposure group were exposed to WAG, and the 82 non-OR staff in the control group were not exposed to WAG.
Article Synopsis
- * The study found that when cultured neurons from mice and human neuroblastoma cells were exposed to high glucose and isoflurane, there was increased toxic damage and higher calcium concentrations.
- * Blocking TRPC channels or reducing TRPC6 expression decreased calcium levels and neurotoxicity, suggesting that high glucose boosts TRPC expression, leading to increased calcium influx and heightened neurotoxic effects from isoflurane.