Publications by authors named "Chang-Lin Du"
Alcoholic liver disease (ALD) caused by chronic alcohol abuse involves complex processes from steatosis to fibrosis, cirrhosis, and hepatocellular carcinoma, posing a global health issue. Bromodomain protein 4 (BRD4) typically serves as a "reader" modulating the functions of transcription factors involved in various biological processes and disease progression. However, the specific mechanisms underlying alcoholic liver injury remain unclear.
View Article and Find Full Text PDFAims: This study aimed to elucidate the role of Interleukin-11 (IL-11) in hepatic fibrosis (HF) and its potential as a therapeutic target for HF treatment.
Materials And Methods: We investigated IL-11 expression in patients with varying degrees of liver injury through ELISA and immunohistochemistry. A CCl-induced HF mouse model was constructed to study IL-11 expression and cell apoptosis using Western blotting (WB) and other techniques.
Article Synopsis
- Macrophage infiltration around tubular epithelial cells (TECs) is a significant feature in diabetic nephropathy (DN), and the communication between these cells is not well understood.
- Researchers found that extracellular vesicles (EVs) enriched with leucine-rich α-2-glycoprotein 1 (LRG1) from macrophages worsened DN in a mouse model, suggesting a link between these cells.
- The study revealed that TECs release EVs that can activate macrophages, leading to inflammation and apoptosis in lipid-damaged TECs, highlighting a novel communication pathway that could be targeted for therapeutic interventions.