Publications by authors named "Chang-Jin Jung"

Article Synopsis
  • A study comparing comorbidities in patients with psoriasis and atopic dermatitis (AD) found that psoriasis patients had significantly higher odds of conditions like obesity, hypertension, diabetes, chronic kidney disease, and Parkinson's disease.
  • The analysis included 14,128 patients and utilized data from Asan Medical Center to assess how these comorbidities are associated with different psoriasis subtypes.
  • Specifically, plaque psoriasis was linked to multiple conditions, while guttate psoriasis had higher odds of dementia, and generalized pustular psoriasis was associated with a significantly higher risk of diabetes.
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Background: Prurigo nodularis (PN) is an intensively pruritic skin disease that negatively influences quality of life. Cryosim-1 (Intrinsic IB Spot) is a synthetic, selective transient receptor potential melastatin 8 agonist.

Aims: To investigate the efficacy and safety of cryosim-1 in PN patients.

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Linear lichen planus pigmentosus is a rare subtype of lichen planus pigmentosus that follows Blaschko's lines, leaving long-standing residual atrophy and pigmentation, especially in dark-skinned populations. Conventional treatments have several limitations regarding the alleviation of pigmentation and atrophy. We report two cases of Korean women with linear lichen planus pigmentosus on their faces who were successfully treated with fractional lasers and intralesional injection of polydeoxyribonucleotide.

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Background: Distinguishing benign lesion from early malignancy in melanocytic lesions of the nail unit still remains a diagnostic challenge, both clinically and histopathologically. While several immunohistochemistry (IHC) stainings have been suggested to help discriminate benign subungual melanocytic proliferation (SMP) and subungual melanoma in situ (MIS), the diagnostic utility of IHC staining for cyclin D1 and PRAME has not been thoroughly investigated in melanocytic lesions of nail unit.

Methods: This retrospective study included cases of benign SMP and subungual MIS confirmed by biopsy at Asan Medical Center from January 2016 to December 2020.

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Background/objectives: The clinical implications of facial involvement in pediatric patients with psoriasis have not been adequately studied. The objectives of this study are to evaluate the association between facial involvement and clinical features including disease severity of psoriasis in children and adolescents.

Methods: The clinical features of patients aged below 20 years diagnosed with psoriasis were retrospectively evaluated and grouped based on the presence or absence of facial involvement at presentation.

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Excessive accumulation of submental fat (SMF) causes a lower face cosmetic problem. A lipolytic injectable has recently been developed as a solution. The objective of this study is to investigate the effects and safety of DWJ211 (a newly developed lipolytic injectable) in the reduction of SMF and to identify the optimum dose.

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Several studies have determined the correlation between programmed cell death protein-1 (PD-1) and chronic plaque psoriasis (CPP). However, limited studies have assessed the association between PD-1 expression and the clinicoprognostic and distinct clinicopathological characteristics of CPP and guttate psoriasis (GP). Twenty-nine patients with skin biopsy-confirmed CPP were recruited at the Asan Medical Center between January 2018 and June 2020, and 33 patients with biopsy-confirmed GP were enrolled between January 2002 and June 2020.

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In recent years, variable rejuvenation techniques, such as hyaluronic acid (HA) fillers and radiofrequency (RF) devices, have become popular. We evaluated the RF hydro-injector (RFHI) device that simultaneously delivers both a microneedle intradermal RF treatment and a HA filler injection to overcome the disadvantages of HA filler and RF devices alone. This study aimed to assess the efficacy and safety of the RFHI device for the rejuvenation of the periorbital area, including the lateral canthal lines (LCLs) and the infraorbital area.

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Background: There are limited data regarding the difference in progression pattern between acral melanoma and nonacral melanoma.

Aims: The objectives of this study were to compare the progression pattern between acral and nonacral melanoma and evaluate its impact on clinical outcomes.

Methods: Clinical and histopathological features, survival outcomes and prognostic factors of 492 patients with acral melanoma or nonacral melanoma were retrospectively evaluated using the Asan Medical Center database.

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The aim of this study was to evaluate the safety and efficacy of combined 1060-nm diode laser and 635-nm low-level laser therapy (LLLT) device for non-invasive reduction of the abdominal and submental fat. Forty-two healthy subjects received single laser treatment on both the abdomen and submental area. Ultrasound images measuring the thickness of abdominal and submental fat were taken at baseline, follow-up at 4, 8, and 12 weeks after treatment.

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Background: Kaposi sarcoma (KS) is a mesenchymal tumor with distinct histopathological features according to stage of progression. Programmed death-1 (PD-1) and its ligand PD-L1 play major roles in the immune escape strategy of tumors.

Objectives: This study evaluated expression of PD-1 and PD-L1 in various stages of KS and investigated associations between their expression and clinical characteristics.

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Because primary skin cancers in organ transplant recipients are rare, little is known about the characteristics and risk factors for skin cancers in organ transplant recipients. We searched the Asan Medical Center database of 13 469 organ transplant recipients for cases of all skin cancers from January 1990 to December 2018. Characteristics of and risk factors for skin cancers were analyzed and compared according to the period of transplantation.

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Traditional attempts at alleviating photoaging-associated facial pigmentation conditions such as melasma, mottled hyperpigmentation, and post-inflammatory hyperpigmentation have yielded disfiguring cosmetic results. Laser toning using a low-fluence Q-switched 1064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser has been more commonly applied to date. However, the treatment efficacy and safety of this approach have not been widely reported.

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Article Synopsis
  • Laugier-Hunziker Syndrome (LHS) is characterized by dark pigmentation of the lips and oral mucosa, unlike Peutz-Jeghers syndrome which involves gastrointestinal issues.
  • Treatments such as Q-switched lasers and cryotherapy are used, but there's limited information on long-term results regarding recurrence of lesions.
  • A case study of a patient treated with QS-ND:YAG laser seven years earlier shows that while some areas remained clear, new recurrent lesions appeared, which were successfully treated again with the same laser technique.
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Gordonia species were recently found to cause human infection. Most Gordonia bronchialis infections are associated with sternal wounds and foreign bodies. Here, we present a case of a firm cutaneous nodule caused by G.

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The radial artery pulse is one of the major diagnostic indices used clinically in both Eastern and Western medicine. One of the prominent methods for measuring the radial artery pulse is the piezoresistive sensor array. Independence among channels and an appropriate sensor arrangement are important for effectively assessing the spatial-temporal information of the pulse.

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  • Traditional East Asian medicine (TEAM) theory suggests the tongue reflects the state of qi and blood, leading to a study of its condition in elderly individuals without apparent disease.
  • A study with 454 elderly participants identified two groups: a normal group and a sleep disorder group, analyzing tongue images for color variations over time.
  • Findings indicated that the sleep disorder group exhibited paler tongue colors and more extensive coating, supporting the theory that these characteristics signify qi and blood deficiency.
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  • This study explored how human skin properties can help diagnose health conditions by focusing on Sasang constitutional medicine (SCM), which correlates constitutional types with specific skin characteristics.
  • The research involved 111 healthy females aged 50-70, measuring skin properties like perspiration and elasticity on various body parts using specialized equipment.
  • Results indicated significant differences between the Sasang constitution types (Soeum-in and Taeeum-in) in skin features, such as lower visco-elasticity and higher elasticity hysteresis for Soeum-in, and increased perspiration on the forehead for Taeeum-in.
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Tongue diagnosis is an essential process to noninvasively assess the condition of a patient's internal organs in traditional medicine. To obtain quantitative and objective diagnostic results, image acquisition and analysis devices called tongue diagnosis systems (TDSs) are required. These systems consist of hardware including cameras, light sources, and a ColorChecker, and software for color correction, segmentation of tongue region, and tongue classification.

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