[Clinical study on modified Topping-off technology in the treatment of multiple lumbar degenerative diseases].

Objective: To explore the clinical effect of the modified Topping-off technique in the treatment of multiple lumbar degenerative diseases.

Methods: From October 2019 to May 2020, 42 patients who underwent modified Topping-off operation (modified Topping-off group) and 42 patients who underwent multilevel total laminectomy and interbody fusion with screw rod system internal fixation (whole laminectomy group) were observed and analyzed. There were 15 males and 27 females in the modified Topping-off group, aged from 28 to 80 years old, with an average of (59.

Atsttrin reduces lipopolysaccharide-induced neuroinflammation by inhibiting the nuclear factor kappa B signaling pathway.

Progranulin is closely related to neuronal survival in a neuroinflammatory mouse model and attenuates inflammatory reactions. Atsttrin is an engineered protein composed of three progranulin fragments and has been shown to have an effect similar to that of progranulin. Atsttrin has anti-inflammatory actions in multiple arthritis mouse models, and it protects against further arthritis development.

Whole mitochondrial genome sequence of a rat rheumatoid arthritis E3 strain.

We sequenced a complete mitochondrial genome sequence of a rat rheumatoid arthritis disease E3 strain for the first time. The total length of the mitogenome was 16,305 bp and coding 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes. This mitochondrial genome sequence will provide new genetic resource into rheumatoid arthritis disease.