Terpene and lignan glycosides from the leaves of Cyclocarya paliurus and their anti-inflammatory activity.

Nine undescribed glycosides including five terpene glycosides (1-5) and four lignan glycosides (6-9), together with thirteen known compounds, were isolated from the n-BuOH fraction of the leaves of Cyclocarya paliurus. Their structures including absolute configuration were elucidated by extensive spectroscopic analysis and computational methods including NMR and ECD calculations. All isolates were screened for inhibitory effect against LPS-induced nitric oxide production in RAW 264.

Comparisons of Whole Saliva and Cell Free Saliva by DIA-Based Proteome Profiling.

Background: Saliva has emerged as a promising diagnostic resource due to its accessibility, noninvasiveness, and repeatability, enabling early disease detection and timely intervention. However, current studies often overlook the distinction between whole saliva (WS) and cell-free saliva (CFS). Objective This study aims to compare the proteomic profiles of WS and CFS.

Real-time monitoring of abnormal mitochondrial viscosity in glioblastoma with a novel mitochondria-targeting fluorescent probe.

Glioblastoma is the most fatal and insidious malignancy, due to the existence of the blood-brain barrier (BBB) and the high invasiveness of tumor cells. Abnormal mitochondrial viscosity has been identified as a key feature of malignancies. Therefore, this study reports on a novel fluorescent probe for mitochondrial viscosity, called ZVGQ, which is based on the twisted intramolecular charge transfer (TICT) effect.