Publications by authors named "Chang-Hwa Ham"

Spinal cord injury (SCI) following high-energy trauma often leads to lasting neurologic deficits and severe socioeconomic impact. Effective neurointensive care, particularly in the early stages post-injury, is essential for optimizing outcomes. This review discusses the role of neurointensive care in managing SCI, emphasizing early assessment, stabilization, and intervention strategies based on recent evidence-based practices.

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Objective: Anterior cervical discectomy and fusion (ACDF) with anterior plating is a commonly performed procedure for cervical disc diseases. While the clinical outcomes of most reported multilevel ACDF cases are excellent, symptomatic pseudarthrosis remains a challenge, often requiring revision surgeries. This study aims to present the radiological characteristics of multilevel ACDF constructs, which can be considered during intraoperative management to prevent pseudarthrosis.

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Article Synopsis
  • The ligamentum flavum (LF) is essential for spinal stability, but its hypertrophy can lead to lumbar spinal canal stenosis (LSCS), with the underlying mechanisms not fully understood.
  • The study explored cellular composition and signaling pathways in hypertrophied LF tissues obtained from patients with LSCS using single-cell RNA sequencing.
  • Findings revealed that fibroblasts were the dominant cell type, with key signaling pathways identified that facilitate chronic inflammation and the trans-differentiation of fibroblasts into myofibroblasts, which may have implications for treating LSCS.
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Calcium pyrophosphate deposition disease (CPPD), known as pseudogout, is characterized by the accumulation of calcium pyrophosphate crystals in musculoskeletal structures, primarily joints. While CPPD commonly affects various joints, involvement in the cervical spine leading to myelopathy is rare. Surgical intervention becomes necessary when conservative measures fail, but reports on full endoscopic surgeries are extremely rare.

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  • This study investigates the hazardous effects of surgical smoke generated by electrocautery during spine surgeries, focusing on particulate matter (PM) and formaldehyde (HCHO) levels.
  • Patients undergoing lumbar spinal fusion were monitored, measuring PM in various sizes (0.3 to 10 µm) and HCHO levels; significant increases in both were noted with electrocautery use.
  • The use of surgical smoke suction effectively reduced PM levels, highlighting the importance of minimizing hazardous smoke exposure in surgical environments.
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Study Design: Retrospective cohort study.

Objective: To evaluate psychosocial effect of brace treatment in adolescent idiopathic scoliosis (AIS) using EuroQoL 5-dimension (EQ-5D) depression and anxiety category.

Background: AIS is a structural abnormality of the spine often affecting patients during the puberty, a critical period of developing psychosocial problems.

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Background: It is difficult to predict the expected survival after lumbar instrumented surgery for metastases owing to the difference among different cancer origins and the relatively short survival after surgery.

Aims: The aim of this study is to analyze the postoperative survival period of lumbar spinal metastasis patients who underwent lumbar instrumented surgery.

Methods: Data were collected from the Korean National Health Insurance Review and Assessment Service database.

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Avulsion fracture of the occipital condyle are rare lesion at craniovertebral junction. It is often related to high-energy traumatic injuries and show diverse clinical presentations. Neurologic deficit and instabilities may justify surgical treatment.

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Study Design: Retrospective Cohort Study OBJECTIVE: Myelopathy following ossification of the posterior longitudinal ligament (OPLL) is one of the devastating clinical features in these patients, while we still know little about which factors are associated with development of myelopathy. We evaluated the difference of radiologic measurements between OPLL patients with or without myelopathy and searched for the clinical significance with emphasis on the impact of dynamic motion.

Methods: 305 patients diagnosed of OPLL were enrolled for retrospective review.

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Background: Perioperative prophylactic antibiotic (PPA) use in spine surgery is known to reduce the rate of surgical site infections. In the past decade, several evidence-based guidelines have been published and surveillance systems to monitor the proper use of antimicrobials had been adapted by many institutes.

Objective: To report the trends of PPA prescription in lumbar fusion surgeries nationwide in the Republic of Korea.

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Objective: We developed a novel multi-torsional mechanical stretch stress loading device for ligamentum flavum cells and evaluated its influence on the development of ligamentum flavum hypertrophy, a common cause of lumbar spinal canal stenosis.

Materials And Methods: Stretch strength of the device was optimized by applying 5% and 15% MSS loads for 24, 48, and 72 h. A cytotoxicity assay of human ligamentum flavum cells was performed and the results were compared to control (0% stress).

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Background: Sagittal spinopelvic alignment (SSPA) parameters are essential for the diagnosis of adult spinal deformities (ASDs) and their progression. Certain clinical symptoms that occur in patients with lumbar spinal stenosis (LSS) and herniated nucleus pulposus (HNP) may distort the SSPA and mimic ASD.

Objective: To differentiate SSPA in symptomatic patients from asymptomatic patients within 10 minutes in the standing position.

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Intervertebral disc (IVD) degeneration is the main source of intractable lower back pain, and symptomatic IVD degeneration could be due to different degeneration mechanisms. In this article, we describe the molecular basis of symptomatic IVD degenerative disc diseases (DDDs), emphasizing the role of degeneration, inflammation, angiogenesis, and extracellular matrix (ECM) regulation during this process. In symptomatic DDD, pro-inflammatory mediators modulate catabolic reactions, resulting in changes in ECM homeostasis and, finally, neural/vascular ingrowth-related chronic intractable discogenic pain.

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Objective: Classification systems for cervical ossification of the posterior longitudinal ligament (OPLL) have traditionally focused on the morphological characteristics of ossification. Although the classification describes many clinical features associated with the shape of the ossification, including the concept of spondylosis seems necessary because of the similarity in age distribution.

Methods: Patients diagnosed with OPLL who presented with increase signal intensity (ISI) on magnetic resonance imaging were surgically treated in our department.

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Objective: Since the first discovery of the 2019 novel coronavirus (COVID-19), rapid and wide spread of the disease has been reported and the World Health Organization announced that a 'pandemic' has started. Up to date there is little known regarding the impact of this outbreak on spinal specialists' daily clinical practice. We intended to evaluate how COVID-19 has affected the number of spinal disease patients we meet and operate in daily practice.

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Soft tissue reaction following metallic debris formation with the use of guided growing rod system has not been previously reported in human. The purpose of this study is to report complications caused by metallosis in a guided growing rod system. A 9-year-old female patient, who underwent treatment for the progressive idiopathic scoliosis (with Cobb's angle of 71°) with the guided growing rod system.

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Article Synopsis
  • The study compares the biomechanical stability of femurs after removing two types of fixation devices: proximal femoral nail antirotation (PFNA-II) and dynamic hip screw (DHS).
  • A total of 56 paired cadaveric femurs were tested, showing that both device removals resulted in significantly lower stability measures (ultimate load and stiffness) compared to intact femurs, but no difference in stability was found between the PFNA-II and DHS devices.
  • Different types of fractures (intertrochanteric and subtrochanteric) emerged based on which device was used due to variations in stress points, indicating that while stability is reduced, the fracture patterns depend on the specific fixation device.
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Although several heat shock proteins have been investigated in relation to tooth development, no available information is available about the spatial and temporal expression pattern of heat shock protein 60 (Hsp 60). To characterize Hsp 60 expression in the structures of the developing tooth germ, we used Western blotting, immunohistochemistry and in situ hybridization. Hsp 60 was present in high amounts in the inner and outer enamel epithelia, enamel knot (EK) and stratum intermedium (SI).

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Background: Risser's sign is an established radiological marker for predicting growth potential in adolescent idiopathic scoliosis, but the accuracy of Risser's staging has been debated. This research was designed to evaluate the accuracy of Risser's staging and to identify causes of errors in Risser's staging.

Materials And Methods: Plain radiographs of 89 adolescent idiopathic scoliosis patients were evaluated for Risser's stage using both the Original and French methods.

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