Publications by authors named "Chang-Hong Zhang"
Article Synopsis
- - The study aimed to assess the impact of bi-level positive airway pressure (BIPAP) therapy on patients with chronic obstructive pulmonary disease (COPD) who also suffer from anxiety and depression, involving 100 participants.
- - Patients were split into two groups: one received standard treatment while the other had BIPAP added, and various health indicators, including respiratory function, quality of life scores, and anxiety/depression scales, were measured for comparison.
- - Results showed that the group using BIPAP exhibited greater improvements in lung function and reductions in symptoms of anxiety and depression compared to the control group, suggesting its potential benefits in managing these comorbid conditions.
Emerging research has suggested the anticancer potential of tanshinone IIA, the bioactive ingredient isolated from the traditional Chinese herb Salvia miltiorrhiza. However, the molecular mechanism of sodium tanshinone IIA sulfonate (STS) antilung cancer effect is not very clear. In this study, our purpose is to investigate the roles of STS and elongation factor-2 kinase (eEF-2K) in regulating the proliferation, migration, and invasion of A549 cells and explore the implicated pathways.
View Article and Find Full Text PDFContext: Lung cancer, the most common type of cancer, has a high mortality rate. Cucurbitacin B (CuB), a natural compound extracted from Cucurbitaceae plants, has antitumor effects.
Objective: We investigated the role of CuB on lung cancer and its potential mechanisms.
Exosomes isolated from mesenchymal stem cells (MSC) had shown beneficial effect on acute lung injury (ALI). However, the effective components in MSC-derived exosomes need further investigation. ALI mice model was established by lipopolysaccharide (LPS) injection.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how Chinese adults use the internet and its connection to their sleep patterns, as most existing research has focused on children and adolescents.
- - Data from 19,730 participants were analyzed, revealing that less than 20% used the internet, primarily through mobile phones, with an average participant age of 56 years.
- - The findings suggest that while internet use is linked to longer sleep duration, it does not significantly impact short sleep duration after accounting for other factors.
Article Synopsis
- The study investigates the prevalence and patterns of comorbidity among middle-aged and elderly people in China, highlighting a gap in current research that often focuses on single chronic diseases.
- Utilizing data from the China Health and Retirement Longitudinal Study, the research found that 42% of the 6754 participants reported having at least one chronic condition, with common diseases including hypertension, arthritis, and digestive issues.
- The findings suggest that hypertension is frequently part of various disease combinations, indicating a need for improved screening and preventive measures for chronic diseases among older adults.
Article Synopsis
- - The study investigated how childhood trauma affects alexithymia (difficulty in identifying emotions) among medical students in China and whether psychological capital (an individual’s positive psychological resources) plays a mediating role in this relationship.
- - Researchers surveyed 1,200 medical students using established questionnaires, finding that 16.5% exhibited alexithymia and identified a significant positive correlation between childhood trauma and alexithymia, with psychological capital partially mediating this effect.
- - The findings suggest that addressing psychological capital could be a potential intervention to mitigate alexithymia in medical students, highlighting the need for support systems in healthcare education.
Article Synopsis
- Dihydroquercetin (DHQ) has shown various beneficial biological activities, including anti-inflammatory and antioxidant properties, but its impact on acute lung injury (ALI) had not been previously studied.
- In experiments, DHQ was found to increase the expression of miR-132-3p, which then inhibited FOXO3, leading to a reduction in inflammation and cell death in LPS-induced ALI.
- The study suggests that targeting the miR-132-3p/FOXO3/NF-κB pathway might offer new therapeutic options for treating ALI.
Background: Asthma, a common chronic inflammatory disease, is treated with corticosteroid in most cases, but corticosteroid resistance in severe asthma patients seriously impairs the therapeutic effects. LncRNA-CASC7 inhibits cell proliferation and enhances drug sensitivity, but the molecular mechanisms of corticosteroid resistance in severe asthma are still unknown.
Methods: Airway smooth muscle cells (ASMCs) from healthy and severe asthmatic subjects were used in this study.
[Influence of S-nitrosoglutathione on the membrane glycoprotein of frozen platelets].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2013
This study was purposed to explore the influence of S-nitrosoglutathione (GSNO) on membrane glycoprotein of frozen platelet. The levels of membrane glycoprotein on fresh liquid platelets, frozen platelets and frozen platelets with GSNO were measured by flow cytometry. The results showed that the GSNO obviously decreased platelet aggregation, the PAC-1 change in the three groups was not significant.
View Article and Find Full Text PDF[Important role of nitric oxide in stored red blood cells -- review].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
June 2009
The efflux of nitro oxide (NO) in the duration of storing red blood cells (RBCs) was the main reason resulting in decrease and even loss of vasodilatory activity, cell deformability and ability of carrying oxygen (O2) in the stored RBCs. The deep understanding physical functions and acting ways of NO in circulatory system, as well as transformations and balance control of S-Nitrosohemoglobin (SNO-Hb) has an important significance for ensuring sure safety and efficacy of transfusion. In this article, the physical functions, acting ways, retaining and transferring form of nitro oxide, and SNO-Hb adjusting, as well as effects of SNO-Hb concentration on change on stored red blood cells were reviewed.
View Article and Find Full Text PDF[Detection and analysis of CD271, CD133 and CD34 expressions in bone marrow cells by flow cytometry with three color fluorescence labelling].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2009
This study was purposed to detect the expressions of CD271, CD133 and CD34, and to analyze the correlation of CD271 with CD133 and CD133 with CD34 expressions. The human bone marrow cells (BMCs) and mononucleated cells (MNCs) were detected by flow cytometry with CD45-PerCP, CD271-FITC, CD133-PE and CD34-FITC labelling according to different combinations of design, cells were located and selected repeatedly by FSC, SSC and CD45 after acquirement, then the expressions of CD271, CD133 and CD34 were detected by flow cytometry. The results showed that the expressions of CD271, CD133 and CD34 in BMCs were 0.
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