Publications by authors named "Chang-Hong Xiao"
Article Synopsis
- Lung injury is a common issue in rheumatoid arthritis (RA) that often goes unnoticed early on, impacting patients' quality of life and contributing to their mortality.
- The study used tandem mass tag-labeled proteomics to analyze lung tissue from RA model rats with secondary lung injury, identifying 310 differentially expressed proteins (DEPs) to better understand their role in this condition.
- Significant findings included upregulation of pathways related to fatty acid metabolism and inflammation, suggesting potential biomarkers for early diagnosis and targets for therapeutic intervention in RA-related lung injuries.
Objective: To investigate the effect and safety of the complementary use of the extract of Artemisia annua L. (EAA) on treating active rheumatoid arthritis (RA).
Methods: A randomized controlled clinical trial was performed.
[The correlation study on syndrome differentiation of rheumatoid arthritis and joint high frequency ultrasound performance].
Zhongguo Zhong Xi Yi Jie He Za Zhi
January 2015
Objective: To observe the differential effect of joint ultrasound on the syndrome differentiation of rheumatoid arthritis (RA) by observing the high frequency ultrasound performances among inactive stage and different syndromes in active stage.
Methods: Totally 83 RA patients in the active stage were assigned to the dampness heat syndrome group (DHS, 59 cases)and the cold dampness syndrome group (CDS, 24 cases) according to Chinese medicine (CM) syndrome typing. Besides, 20 RA patients in the remission stage were recruited as the control group (abbreviated as the remission group).
[Effect of sanshui baihu decoction on the proliferation of fibroblast-like synoviocytes and its secretion of IL-6 and IL-17].
Zhongguo Zhong Xi Yi Jie He Za Zhi
October 2013
Objective: To observe the effect of Sanshui Baihu Decoction (SBD) containing serum on the proliferation of in vitro cultured fibroblast-like synoviocytes (FLS) derived from rheumatoid arthritis (RA) and osteoarthritis (OA) and its secretion of interleukin-6 (IL-6) and IL-17, and to explore the pharmacological mechanism of SBD.
Methods: The FLS obtained from cultured RA and OA patients' synovial tissue were cultured and passaged in vitro in a routine way. The cultured medium was changed to DMEM with 20% SBD containing serum and cultured for 72 h after cultured for 3 to 6 generations.
Objective: To investigate the effects of methanol extract of Celastrus orbiculatu (MECO) on synovial hyperplasia and cartilage erosion and degradation in rheumatoid arthritis (RA), and explore the possible mechanisms to provide clues for new drug development for RA treatment.
Methods: The articular synovium from patients with RA and normal articular cartilage were co-implanted into the back of severe combined immunodeficient (SCID)mice to establish the chimeric model SCID- HuRAg. Four weeks later, the mice were given MECO intragastrically at 30 mg/day, leflunomide at 500 microg/day or distilled water, respectively, for 4 consecutive weeks.