Prevention, treatment and potential mechanism of herbal medicine for Corona viruses: A review.

The pandemic of coronavirus disease 2019 (COVID-19) caused by the SARS-coronavirus 2(SARS-CoV-2) virus has become the greatest global public health crisis in recent years,and the COVID-19 epidemic is still continuing. However, due to the lack of effectivetherapeutic drugs, the treatment of corona viruses is facing huge challenges. In thiscontext, countries with a tradition of using herbal medicine such as China have beenwidely using herbal medicine for prevention and nonspecific treatment of corona virusesand achieved good responses.

Genistein stimulates the osteoblastic differentiation via NO/cGMP in bone marrow culture.

The soybean phytoestrogen, genistein (Gen), has anabolic effects on bone through mechanisms that remain to be elucidated. We examined the role of nitric oxide (NO) and its downstream effector guanylyl cyclase (GC) in mediating the effects of Gen on the proliferation and osteoblastic maturation of primary mouse bone marrow-derived mesenchymal stem cells (BMSCs). Gen (10(-8) approximately 10(-6) M) resulted in a dose-dependent increase in cell proliferation as measured by increased [3H]thymidine incorporation, and stimulated osteoblastic maturation as assessed by culture duration-dependent increments in alkaline phosphatase (ALP) activity, calcium deposition into extracellular matrix and Runx2/Cbfa1 gene expression in BMSCs cultures.

Phenotype distribution and gender-related differences of CYP2E1 activity in a Chinese population.

1. The aim was to investigate the phenotype distribution characteristic and gender-related differences of CYP2E1 activity in a healthy Chinese population. 2.

Inducibility of CYP1A2 by omeprazole in vivo related to the genetic polymorphism of CYP1A2.

Aims: To evaluate the effect of the CYP1A2*1C and CYP1A2*1F polymorphisms on the inducibility of CYP1A2 by omeprazole in healthy subjects.

Methods: Mutations of CYP2C19 and CYP1A2 were identified by PCR-RFLP. Omeprazole, 120 mg day-1, was given to 12 extensive metabolizers (EM) with respect to CYP2C19 (six CYP1A2*1F/CYP1A2*1F and six CYP1A2*1C/CYP1A2*1F of CYP1A2) for 7 days.

One-stage correction of congenital complex penile curvature by tunica albuginea plications.

Background And Purpose: Congenital complex penile curvature has two deformity components: torsion and curvature of the penile shaft. Limited cases have been reported and were managed with an invasive Nesbit procedure. We introduce a novel simple surgical technique to correct the deformity in one stage.

Genotype of CYP3AP1 associated with CYP3A activity in Chinese Han population.

Aim: To investigate the distribution of genotype of CYP3AP1 in Chinese Han population and the correlation with CYP3A activity.

Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed in CYP3AP1 genotype analysis; using midazolam as probe drug, CYP3A activity of 191 Chinese healthy subjects was measured by plasma 1'-hydroxymidazolam/midazolam (1'-OH-MDZ/MDZ) ratio at 1 h after oral administration of 7.5 mg midazolam.

Congenital isolated penile torsion in adults: untwist with plication.

To correct congenital isolated penile torsion, we delineated a parabolic curve as a counterdirection to the torsion after artificial erection was induced. Two areas along the curve were chosen and plicated with two interrupted U-shaped sutures. Satisfactory functional and cosmetic results were achieved in 3 patients.