Toxicity and Efficacy Evaluation of Soluble Recombinant Ricin Vaccine.

Background: Ricin, a toxin extracted from the seeds of , is classified as a ribosome-inactivating protein. The A-subunit of ricin shows RNA -glycosidase activity that cleaves ribosomal RNA (rRNA) and exhibits toxicity by inhibiting protein synthesis and inducing vascular leak syndrome.

Methods: In this study, we created a truncated version of the previously developed R51 ricin vaccine (RTA 1-194 D75C Y80C) through in silico analysis.

Trivalent arsenicals induce skin toxicity through thiol depletion.

Arsenic, a widespread environmental contaminant, is highly toxic to human health. Arsenic exposure is associated with the occurrence of skin lesions and diseases. This study investigated the dermal toxicity of trivalent arsenicals (As and MMA) and its underlying mechanism using human keratinocyte cell line and ex vivo porcine skin.

Quadriplegia, Dysphagia and Ataxia Manifested in a Child With COVID-19 Related Acute Necrotizing Encephalopathy: A Case Report.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, presents primarily with respiratory symptoms. However, children with COVID-19 are usually asymptomatic or mild acute symptoms and also neurological manifestations have also been observed. We report the case of a 7-year-old girl who presented with high fever and altered mental status, leading to a diagnosis of COVID-19 and acute necrotizing encephalopathy (ANE).

Microlens array camera with variable apertures for single-shot high dynamic range (HDR) imaging.

We report a microlens array camera with variable apertures (MACVA) for high dynamic range (HDR) imaging by using microlens arrays with various sizes of apertures. The MACVA comprises variable apertures, microlens arrays, gap spacers, and a CMOS image sensor. The microlenses with variable apertures capture low dynamic range (LDR) images with different f-stops under single-shot exposure.

Is hyper-selectivity a root of Asian American children's success?

Asian immigrants' children, even those from lower-backgrounds, tend to acquire higher levels of education than other ethnoracial groups, including White natives. Asian culture is often cited as a conventional explanation. The hyper-selectivity hypothesis challenges conventional wisdom by arguing that Asian American culture is an outcome of the community resources associated with hyper-selectivity.

Network Ties, Upward Status Heterophily, and Unanticipated Health Consequences.

Using cross-national data containing information on the status rank of network alters, this study investigates the potential negative effects of "upward status heterophily," ties to and perceived interaction with higher status others. According to our main finding, upward status heterophily is associated with poor physical health and lower subjective well-being. We also find that this focal relationship varies across individual and contextual moderators.

Pretreatment of rhesus monkeys with transdermal patches containing physostigmine and procyclidine: implications of the delivery system for the potential application against VX nerve agent intoxication in humans.

Physostigmine (Phs) is a reversible inhibitor of acetylcholinesterase (AChE) that penetrates the blood-brain barrier (BBB) and could be used to protect the central nervous system (CNS) against the effects of nerve agents. For prophylactic effectiveness, long, steady, and adequate inhibition of AChE activity by Phs is needed to broadly protect against the CNS effects of nerve agents. Here, we evaluated the efficacy of transdermal patches containing Phs and procyclidine (PC) as prophylactic agents.

Gravity and magnetic anomalies of earthquake-prone areas in the southwestern Ulleung basin margin, East Sea (Sea of Japan).

Submarine earthquakes have increased in the southwestern Ulleung Basin adjacent to the Korean Peninsula. This study analyzed the gravitational and magnetic properties of the three earthquake-prone areas (Hupo Bank and offshore regions near Pohang and Ulsan) in the basin. The basin was affected by tensile and compressive stresses during the formation of the East Sea.

Lithium-Metal Batteries: From Fundamental Research to Industrialization.

Lithium-metal batteries (LMBs) are representative of post-lithium-ion batteries with the great promise of increasing the energy density drastically by utilizing the low operating voltage and high specific capacity of metallic lithium. LMBs currently stand at a point of transition at which the accumulation of knowledge from fundamental research is being translated into large-scale commercialization. This review summarizes the available strategies for addressing the intrinsic shortcomings of LMBs, such as the suppression of dendritic growth and parasitic reactions from the material to the electrode to the cell level.

Which prognostic factors are important for long-term outcomes in symptomatic obstructive colon cancer? A multi-institutional retrospective cohort study.

Purpose: The prognostic factors in obstructive colon cancer have not been clearly identified. We aimed to identify the prognostic factor to establish optimal treatment strategy in obstructive colon cancer.

Methods: Patients who underwent surgery for primary colon cancer in stages II and III with symptomatic obstruction from 2004 to 2010 in six hospitals were retrospectively collected.

Taste-based gender discrimination in South Korea.

Among the countries of the Organization for Economic Co-operation and Development, South Korea shows the worst female earnings disadvantage. Women's career disruption associated with marriage and childbearing is said to be the primary factor behind the huge female disadvantage in Korea. Recent studies, however, demonstrated that substantial female disadvantage appears prior to women's career disruption, even net of human capital covariates.

Who is the "She" in the Pandemic "She-Cession"? Variation in COVID-19 Labor Market Outcomes by Gender and Family Status.

The sharp decline in employment after the COVID-19 lockdown was not uniformly felt across demographic groups. Utilizing the 2017 to 2020 monthly Current Population Survey and using a difference-in-difference design, we investigate the varying impacts of COVID-19 on at-work status among the prime-working-age population, accounting for typical seasonal fluctuations in employment. The target population is grouped by gender, marital status, parenthood, and level of education.

Prediction of Postoperative Sepsis Based on Changes in Presepsin Levels of Critically Ill Patients with Acute Kidney Injury after Abdominal Surgery.

Presepsin (PSP) is a viable biomarker for the detection of bacterial infection, but it lacks accuracy when acute kidney injury (AKI) develops. Herein, we evaluated the diagnostic and prognostic value of PSP in predicting postoperative sepsis after abdominal surgery respective to the degree of AKI. A total of 311 patients who underwent abdominal surgery and were admitted to a surgical intensive care unit were enrolled and classified into non-AKI, mild-AKI (stage 1, stage 2 and stage 3 without renal replacement therapy (RRT)) and severe-AKI (stage 3 with RRT) group, according to the Kidney Disease Improving Global Outcomes criteria.

The role of laparoscopic management in perforated gastric cancer.

Purpose: Perforated gastric cancer is an extremely rare condition and usually presents in advanced stage with poor prognosis. Surgical strategies are still controversial regarding the extent to which complete resection or primary repair is performed and the application of laparoscopic techniques. We aim to determine the role of laparoscopic 2-stage approach in perforated gastric cancer.

Prevalence and Progression of Stage 0 Macular Hole in Fellow Eyes of Patients with Idiopathic Full-thickness Macular Hole.

Purpose: To assess the prevalence and progression of a stage 0 macular hole in the fellow eye of patients with an idiopathic full-thickness macular hole.

Methods: The fellow eyes of 189 patients who underwent idiopathic full-thickness macular hole surgery were examined by biomicroscopy and spectral domain-optical coherence tomography (SD-OCT). A subset of 21 fellow eyes with a stage 0 macular hole was observed.

Effect of Ag doping on Pd/Ag-CeO catalysts for CO and CH oxidation.

To achieve high fuel efficiency and low emission in automobiles, it is necessary to develop highly active diesel oxidation catalysts (DOCs). Pd/CeO catalysts have been widely used as active catalysts for CO and CH oxidation reactions. Additionally, Ag has been reported to enhance the oxygen storage capacity (OSC) of CeO, which contributes to the oxidation ability of Pd/CeO.

Effects of La incorporation in catalytic activity of Ag/La-CeO catalysts for soot oxidation.

Owing to strengthened regulations toward vehicle emissions, the use of diesel particulate filter technology to reduce particulate matter emissions has attracted significant attention. To achieve low temperature oxidation of particulate matter, numerous studies on Ag/CeO catalysts for soot oxidation have been reported. Herein, Ag/La-CeO catalysts with different La contents are synthesized and compared to analyze the effect of La.

Roles of noble metals (M = Ag, Au, Pd, Pt and Rh) on CeO in enhancing activity toward soot oxidation: Active oxygen species and DFT calculations.

The effects of noble metal (M = Ag, Au, Pd, Pt, and Rh) on CeO in enhancing the activity toward soot oxidation were studied through experimental methods and density functional theory (DFT) calculations. Each noble metal (3 mol.%) was supported on CeO (M/CeO) and the properties of the catalysts were verified by XRD, HRTEM, N physisorption, CO chemisorption, XPS, and H-TPR results.

COVID-19 and the decline in Asian American employment.

The unemployment rate has sharply increased as a result of the lockdown associated with the spread of COVID-19. The negative effect of the lockdown is more conspicuous among the less-educated workers than the highly-educated workers. Because Asian Americans are more likely to have a bachelor or higher degree than any other racial group, they are expected to be relatively immune to the drop in employment unless the detrimental impact of the lockdown is severer for Asian Americans.

Bacillus subtilis spore vaccines displaying protective antigen induce functional antibodies and protective potency.

Background: Bacillus anthracis is the causative agent of anthrax, a disease of both humans and various animal species, and can be used as a bioterror agent. Effective vaccines are available, but those could benefit from improvements, including increasing the immunity duration, reducing the shot frequency and adverse reactions. In addition, more sophisticated antigen delivery and potentiation systems are urgently required.

Urealess NOx Reduction by Carbon Monoxide in Simulated Lean-Burn Exhausts.

The lean NOx aftertreatment is one of the major barriers to the widespread adoption of advanced combustion powertrains for the reduction of both greenhouse gases and toxic exhausts. Urea/SCR, selective catalytic reduction of NOx by NH generated through urea decomposition, is commonly regarded as the best way to reduce NOx in low temperature lean exhaust. However, the urea/SCR system has inherent drawbacks, i.