Role of efferocytosis in chronic pain -- From molecular perspective.

The complex nature of pain pathophysiology complicates the establishment of objective diagnostic criteria and targeted treatments. The heterogeneous manifestations of pain stemming from various primary diseases contribute to the complexity and diversity of underlying mechanisms, leading to challenges in treatment efficacy and undesirable side effects. Recent evidence suggests the presence of apoptotic cells at injury sites, the distal dorsal root ganglia (DRG), spinal cord, and certain brain regions, indicating a potential link between the ineffective clearance of dead cells and debris and pain persistence.

Analysis and prediction of the incidence temporal trends of echinococcosis in China from 2010 to 2021.

Echinococcosis poses a significant health burden in China, yet previous studies have mainly concentrated on its prevalence rather than incidence trends. This study analyzes echinococcosis incidence from 2010 to 2021 and projects future trends to enhance prevention and control strategies. The annual percentage change (APC) and average annual percentage change (AAPC) were calculated to determine temporal trends, while the time series was decomposed to assess seasonal patterns.

Advances in Symbiotic Bioabsorbable Devices.

Symbiotic bioabsorbable devices are ideal for temporary treatment. This eliminates the boundaries between the device and organism and develops a symbiotic relationship by degrading nutrients that directly enter the cells, tissues, and body to avoid the hazards of device retention. Symbiotic bioresorbable electronics show great promise for sensing, diagnostics, therapy, and rehabilitation, as underpinned by innovations in materials, devices, and systems.

Protein serine/threonine phosphatases in tumor microenvironment: a vital player and a promising therapeutic target.

The tumor microenvironment (TME) is involved in cancer initiation and progression. With advances in the TME field, numerous therapeutic approaches, such as antiangiogenic treatment and immune checkpoint inhibitors, have been inspired and developed. Nevertheless, the sophisticated regulatory effects on the biological balance of the TME remain unclear.

VR-Aided Ankle Rehabilitation Decision-Making Based on Convolutional Gated Recurrent Neural Network.

Traditional rehabilitation training for stroke patients with ankle joint issues typically relies on the expertise of physicians. However, when confronted with complex challenges, such as online decision-making or assessing rehabilitation progress, even seasoned experts may not anticipate all potential hurdles. A novel approach is necessary-one that effectively addresses these complexities without solely leaning on expert experience.

Pain Catastrophizing and Acute Post-Surgical Pain in Knee Arthroplasty Patients: The Moderating Role of Social Support.

Purpose: This study aimed to investigate the correlation between preoperative pain catastrophizing and social support, and acute post-surgical pain in patients who underwent knee arthroplasty. The study also aimed to determine whether social support moderates the role of pain catastrophizing psychologically in acute post-surgical pain after knee arthroplasty.

Patients And Methods: This study recruited participants to survey a tertiary hospital in Dalian, China, between November 2022 and October 2023.

What's behind thoracic surgery explosion in young patients under the age of 40 in Wuhan after COVID-19 outbreak?

Introduction: The COVID-19 pandemic was associated with a dramatic increase of chest CT scanning in Wuhan. This was partly a COVID effect: some private and public employers required employees to have CT examinations to confirm they were healthy before going back to work. But it also likely reflects the growing enthusiasm for low-dose computed tomography (LDCT) screening.

Ampere-level CO electroreduction with single-pass conversion exceeding 85% in acid over silver penetration electrodes.

Synthesis of valuable chemicals from CO electroreduction in acidic media is highly desirable to overcome carbonation. However, suppressing the hydrogen evolution reaction in such proton-rich environments remains a considerable challenge. The current study demonstrates the use of a hollow fiber silver penetration electrode with hierarchical micro/nanostructures to enable CO reduction to CO in strong acids via balanced coordination of CO and K/H supplies.

Surveillance for adverse events following immunization with DTaP-containing combination vaccines in Linping, China, 2019-2022.

Background: The DTaP-Hib and DTaP-IPV/Hib combination vaccine can be used as a substitute for the diphtheria, tetanus, and acellular pertussis combined vaccine (DTaP). We aimed to evaluate the safety of multi-component vaccines containing DTaP by analyzing the reporting rates and characteristics of adverse events following immunization (AEFIs) in Linping District during the years 2019 to 2022.

Methods: We obtained data of AEFI and vaccination from the National AEFI Surveillance System of China and Zhejiang Municipal Immunization Information Management System, respectively, during 2019-2022 for a descriptive, epidemiological analysis.

Synergetic gait prediction and compliant control of SEA-driven knee exoskeleton for gait rehabilitation.

In recent years, lower limb exoskeletons have achieved satisfactory clinical curative effects in rehabilitating stroke patients. Furthermore, generating individualized trajectories for each patient and avoiding secondary injury in rehabilitation training are important issues. This paper explores the utilization of series elastic actuator (SEA) to deliver compliant force and enhance impact resistance in human-robot interaction, and we present the design of novel knee exoskeleton driven by SEA.

Approximate Policy Iteration With Deep Minimax Average Bellman Error Minimization.

In this work, we investigate the utilization of deep approximate policy iteration (DAPI) in estimating the optimal action-value function within the context of reinforcement learning, employing rectified linear unit (ReLU) ResNet as the underlying framework. The iterative process of DAPI incorporates the minimax average Bellman error minimization principle. It employs ReLU ResNet to estimate the fixed point of the Bellman equation, which is aligned with the estimated greedy policy.

Activation of mitochondrial DNA-mediated cGAS-STING pathway contributes to chronic postsurgical pain by inducing type I interferons and A1 reactive astrocytes in the spinal cord.

Chronic postsurgical pain (CPSP) is increasingly recognized as a public health issue. Recent studies indicated the innate immune pathway of cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) was involved in pain regulation. However, the detailed mechanisms remain unclear.

CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1.

The centromere proteins (CENPs), a critical mitosis-related protein complexes, are involved in the kinetochore assembly and chromosome segregation. In this study, we identified that CENPA was significantly up-regulated in HCC and highly expressed CENPA correlated with poor prognosis for HCC patients. Knockdown of CENPA inhibited HCC cell proliferation and tumor growth and .

Corrigendum: Institutional presence: toward a further developed Community of Inquiry model integrating institutional functions in online and blended learning environment.

[This corrects the article DOI: 10.3389/fpsyg.2023.

A novel ferroptosis-related microRNA signature with prognostic value in osteosarcoma.

The induction of ferroptosis is suggested to be a potential therapeutic strategy for cancers. MicroRNAs (miRNAs) are reported to play an important role in cell death processes. This study aims to construct and validate a risk model based on ferroptosis-related miRNAs (FR_miRNAs) to predict prognosis and identify novel therapeutic targets for osteosarcoma.

Highly Efficient CO Reduction at Steady 2 A cm by Surface Reconstruction of Silver Penetration Electrode.

Electroreduction of CO to CO is a promising route for greenhouse gas resource utilization, but it still suffers from impractical current density and poor durability. Here, a nanosheet shell (NS) vertically standing on the Ag hollow fiber (NS@Ag HF) surface formed by electrochemical surface reconstruction is reported. As-prepared NS@Ag HF as a gas penetration electrode exhibited a high CO faradaic efficiency of 97% at an ultra-high current density of 2.

The bidirectional roles of the cGAS-STING pathway in pain processing: Cellular and molecular mechanisms.

Pain is a common clinical condition. However, the mechanisms underlying pain are not yet fully understood. It is known that the neuroimmune system plays a critical role in the pathogenesis of pain.

Institutional presence: Toward a further developed Community of Inquiry model integrating institutional functions in online and blended learning environment.

In this research we examine the Community of Inquiry model and further develop the model by integrating a complementary institutional presence. For this purpose, a questionnaire including five presences and 73 questions was designed. In total, a response of 762 questionnaires from five universities were collected.

Depletion of Tgfbr2 in hepatocytes alleviates liver fibrosis and restores hepatic function in fibrotic mice.

Objectives: Previous studies have demonstrated the pivotal role of transforming growth factor (TGF)-β signaling in activating hepatic stellate cells during liver fibrosis. In this study we aimed to demonstrate the effects and underlying mechanism of TGF-β signaling in hepatocytes on hepatic fibrogenesis.

Methods: Hepatocyte-specific Tgfbr2-knockout (Tgfbr2 ) mice were generated by AAV8-TBG-Cre injection via the tail vein of Tgfbr2 mice.

Variables that influence teachers' practice of differentiated instruction in Chinese classrooms: A study from teachers' perspectives.

As the diversity of students increases, differentiated instruction (DI) serves an increasingly significant function in meeting their individual learning needs. Emerging research has highlighted the value of inclusive teaching approaches to address students' differences, such as DI. Therefore, it is important to quantify teachers' DI thoughts and behaviors in classroom teaching.

A Nine-Level Inverter with Adjustable Turn-Off Time for Helicopter Transient Electromagnetic Detection.

The current inverter is the core component of the helicopter transient electromagnetic (HTEM) detection system. It should meet the concerns of low loss, high power, and fast turn-OFF time. This article proposes a new circuit topology based on nine-level inverter technology to overcome the drawbacks of typical PWM (pulse width modulation) inverters, such as switching losses and harmonics.

Ni Nanoclusters Anchored on Ni-N-C Sites for CO Electroreduction at High Current Densities.

Transition metal catalyst-based electrocatalytic CO reduction is a highly attractive approach to fulfill the renewable energy storage and a negative carbon cycle. However, it remains a great challenge for the earth-abundant VIII transition metal catalysts to achieve highly selective, active, and stable CO electroreduction. Herein, bamboo-like carbon nanotubes that anchor both Ni nanoclusters and atomically dispersed Ni-N-C sites (NiNCNT) are developed for exclusive CO conversion to CO at stable industry-relevant current densities.

Expression Profiles, Prognosis, and ceRNA Regulation of SRY-Related HMG-Box Genes in Stomach Adenocarcinoma.

Aberrant expression of the SRY-related HMG-box (SOX) genes contributes to tumor development and progression. This research aimed to identify the regulation of the SOX genes in stomach adenocarcinoma (STAD). Expression profiles downloaded from The Cancer Genome Atlas (TCGA) were conducted to analyze the expression and function of the SOX genes.

Endoscopic closure of refractory upper GI-tracheobronchial fistulas with a novel occluder: a prospective, single-arm, single-center study (with video).

Background And Aims: Upper GI-tracheobronchial fistula is a morbid condition with high mortality. It is a challenge for endoscopists because currently available treatments have severe limitations. In this study we assessed the efficacy and safety of an occluder we invented for endoscopic closure of refractory upper GI-tracheobronchial fistulas.