Failure risk study of anchor bolts durability for loess slope under long-term hydro-thermal effect.

The long-term safety and durability of anchor systems are the focus of slope maintenance management and sustainable operation. This study presents the observed temperature, humidity, and anchor bolt stress at varying depths from four-year remote real-time monitoring of the selected loess highway cut-slope. The potential correlation between slope hydrothermal environment and anchor stress is analyzed.

PTEN inhibits epithelial mesenchymal transition of thyroid cancer cells by regulating the Wnt/β-Catenin signaling pathway.

Objective: The global incidence of thyroid cancer (THCA) has significantly risen in recent years. This study aims to investigate the role and mechanisms of PTEN in epithelial mesenchymal transition (EMT), invasion and migration of THCA cells.

Methods: PTEN expression in THCA was analyzed through bioinformatics databases.

Study on the Chemical Characterization and Hypolipidemic Function of Based on Its Flavonoid Components.

has great value and development prospects in hypolipidemic applications. In this study, we comprehensively screened out multi-index components relevant to the quality of based on the hypolipidemic function of the flavonoid fraction of (FFN) combined with chemical characterizations. Firstly, in vitro antioxidant and cell experiments evaluated the hypolipidemic function of the FFN.

Description of a new species of the genus Aeromachus Nicéville (Lepidoptera, Hesperiidae, Hesperiinae) from Southwestern China.

A new species of the genus Aeromachus, A. angustifascia sp. nov.

Semi-hydrogenation of alkynes to alkenes over Pd nanoparticles embedded in MoC prepared from a high-temperature pulse.

Pd nanoparticles embedded in MoC were successfully prepared from a high-temperature pulse, and are efficient for semi-hydrogenation of alkynes to alkenes, where the embedded Pd sites possessed appropriate alkyne adsorption but suppressed alkene adsorption, thus exhibiting both high activities and good alkene selectivities in the hydrogenation of various alkynes.

Ultrasound treatment improved gelling and emulsifying properties of myofibrillar proteins from Antarctic krill (Euphausia superba).

Antarctic krill is a promising source of marine proteins with abundant biomass and excellent nutritional profile, but has poor technological properties. Ultrasonic treatment at power levels of 0, 100, 200, 300, 400 and 500 W was applied to improve the technological properties of Antarctic krill meat, and the changes in physicochemical properties of myofibrillar proteins (MPs) were investigated. The results indicated that proper ultrasonic treatment significantly improved the gelling properties of Antarctic krill meat, in terms of a more uniform and stable gel texture and better water holding capacity, which were related to better cross-linking of MPs.

Three-Dimensional Speckle Tracking Echocardiography Assessment of Right Ventricular Function in Chronic Coronary Syndrome Patients After Percutaneous Coronary Intervention.

Objective: This study aimed to assess alterations in right ventricular (RV) function following percutaneous coronary intervention (PCI) in patients with chronic coronary syndromes utilizing three-dimensional speckle tracking echocardiography (3D-STE).

Methods: A prospective study was conducted involving 136 patients diagnosed with chronic coronary syndromes undergoing PCI, constituting the study group, alongside 110 age- and gender-matched healthy volunteers serving as the control group. Echocardiographic evaluations, including both conventional and three-dimensional assessments, were performed on all study participants at 1-week, 6, and 12 months post-PCI.

AI for biofabrication.

Biofabrication is an advanced technology that holds great promise for constructing highly biomimeticthree-dimensional human organs. Such technology would help address the issues of immune rejection and organ donor shortage in organ transplantation, aiding doctors in formulating personalized treatments for clinical patients and replacing animal experiments. Biofabrication typically involves the interdisciplinary application of biology, materials science, mechanical engineering, and medicine to generate large amounts of data and correlations that require processing and analysis.

Panoramic single-pixel imaging with megapixel resolution based on rotational subdivision.

Single-pixel imaging (SPI) using a single-pixel detector is an unconventional imaging method that has great application prospects in many fields to realize high-performance imaging. In particular, the recently proposed catadioptric panoramic ghost imaging (CPGI) extends the application potential of SPI to high-performance imaging at a wide field of view (FOV) with recent growing demands. However, the resolution of CPGI is limited by the hardware parameters of the digital micromirror device (DMD), which cannot meet ultrahigh-resolution panoramic imaging needs that require detailed information.

Bioorthogonal chemistry-based prodrug strategies for enhanced biosafety in tumor treatments: current progress and challenges.

Cancer is a significant global health challenge, and while chemotherapy remains a widely used treatment, its non-specific toxicity and broad distribution can lead to systemic side effects and limit its effectiveness against tumors. Therefore, the development of safer chemotherapy alternatives is crucial. Prodrugs hold great promise, as they remain inactive until they reach the cancer site, where they are selectively activated by enzymes or specific factors, thereby reducing side effects and improving targeting.

5'-nucleotidases contribute to adenosine-mediated immune evasion and virulence in a mouse model.

() is an important swine bacterial pathogen and causes human infections, leading to a wide range of diseases. However, the role of 5'-nucleotidases in its virulence remains to be fully elucidated. Herein, we identified four cell wall-anchored 5'-nucleotidases (Snts) within , named SntA, SntB, SntC, and SntD, each displaying similar domains yet exhibiting low sequence homology.

The Retinal Blood Flow Density Is Related to the Pathological Severity of Diabetic Kidney Disease.

Introduction: This study aimed to investigate the correlation between fundus blood flow parameters and the severity of pathological biopsy in patients with diabetic kidney disease (DKD).

Methods: Data of patients with type 2 diabetes mellitus who completed renal pathology biopsies and optical coherence tomography angiography (OCTA) examinations, including renal function, 24-h urine protein quantification, and macular flow imaging, were collected. DKD pathology biopsies were graded as stages 1-4, and differences and correlations of the parameters were compared between groups.

Computational ghost imaging enhanced by degradation models for under-sampling.

Computational ghost imaging (CGI) allows two-dimensional (2D) imaging by using spatial light modulators and bucket detectors. However, most CGI methods attempt to obtain 2D images through measurements with a single sampling ratio. Here, we propose a CGI method enhanced by degradation models for under-sampling, which can be reflected by results from measurements with different sampling ratios.

Cancer-Associated Fibroblasts in Gastric Cancer Regulate Macrophage Polarization through RCN3 Pathway.

Objective: To explore the role and molecular mechanism of cancer-associated fibroblasts (CAFs) in the tumor microenvironment of gastric cancer (GC).

Methods: The expression of CAFs in GC patients was first assessed for abundance, and survival analysis was performed. Subsequently, The Cancer Genome Atlas (TCGA) data were used for differential analysis, survival analysis, and EPIC analysis, while single-cell data (GSE183904) were downloaded for differential analysis of CAFs.

Gasdermin D could be lost in the brain parenchyma infarct core and a pyroptosis-autophagy inhibition effect of Jie-Du-Huo-Xue decoction after stroke.

Background: The Chinese ethnic medicine Jie-Du-Huo-Xue Decoction (JDHXD) is used to alleviate neuroinflammation in cerebral ischemia (CI). Our previous studies have confirmed that JDHXD can inhibit microglial pyroptosis in CI. However, the pharmacological mechanism of JDHXD in alleviating neuroinflammation and pyroptosis needs to be further elucidated.

Evolutionary patterns and functional effects of 3D chromatin structures in butterflies with extensive genome rearrangements.

Chromosome rearrangements may distort 3D chromatin architectures and thus change gene regulation, yet how 3D chromatin structures evolve in insects is largely unknown. Here, we obtain chromosome-level genomes for four butterfly species, Graphium cloanthus, Graphium sarpedon, Graphium eurypylus with 2n = 30, 40, and 60, respectively, and Papilio bianor with 2n = 60. Together with large-scale Hi-C data, we find that inter-chromosome rearrangements very rarely disrupted the pre-existing 3D chromatin structure of ancestral chromosomes.

ITGAM sustains MAPK signaling and serves as an adverse prognostic factor and therapeutic target in acute myeloid leukemia.

Background: Acute myeloid leukemia (AML) is the second most frequently occurring type of leukemia in adults. Despite breakthroughs in genetics, the prognosis of AML patients remains dismal. The aim of this study is to find new therapeutic targets and diagnostic markers for AML and to explore their mechanisms of action.