Publications by authors named "Chang Yun Rhee"
Background And Aims: Liver fibrosis represents a global health burden, given the paucity of approved antifibrotic therapies. Liver sinusoidal endothelial cells (LSECs) play a major gatekeeping role in hepatic homeostasis and liver disease pathophysiology. In early tumorigenesis, runt-related transcription factor 3 (RUNX3) functions as a sentinel; however, its function in liver fibrosis in LSECs remains unclear.
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- Hypoxic responses are linked to various health issues like inflammation and cancer, sparking interest in natural remedies.
- Recent findings show that Lactiplantibacillus plantarum K8 (K8) has anti-inflammatory effects, but its impact on hypoxia-related cellular responses was previously unknown.
- This study reveals that K8 lysates can significantly suppress HIF1α accumulation and target gene expression under hypoxic conditions, suggesting a unique role in regulating cellular responses to low oxygen levels.